FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age

Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression: CD34 High , with stemness properties (genuine st...

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Veröffentlicht in:	Nature cell biology 2020-11, Vol.22 (11), p.1307-1318
Hauptverfasser:	García-Prat, Laura, Perdiguero, Eusebio, Alonso-Martín, Sonia, Dell’Orso, Stefania, Ravichandran, Srikanth, Brooks, Stephen R., Juan, Aster H., Campanario, Silvia, Jiang, Kan, Hong, Xiaotong, Ortet, Laura, Ruiz-Bonilla, Vanessa, Flández, Marta, Moiseeva, Victoria, Rebollo, Elena, Jardí, Mercè, Sun, Hong-Wei, Musarò, Antonio, Sandri, Marco, del Sol, Antonio, Sartorelli, Vittorio, Muñoz-Cánoves, Pura
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Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/31 14/19 42/109 45/15 45/90 45/91 631/532/2439 631/80 64/110 64/60 Age Age Factors Aging AKT protein Animals Antigens, CD34 - metabolism Biomedical and Life Sciences Cancer Research Cardiotoxins - toxicity CD34 antigen Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation - drug effects Cell Proliferation - genetics Cell Self Renewal - drug effects Cell Self Renewal - genetics Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - genetics Developmental Biology Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead Box Protein O3 - genetics Forkhead Box Protein O3 - metabolism Forkhead protein Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation Genetic aspects Geriatrics Heterogeneity Inactivation Insulin-like growth factor I Life Sciences Male Mice, Inbred C57BL Mice, Knockout Mice, SCID Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - transplantation Muscles Musculoskeletal system Phenotype Physiological aspects Proto-Oncogene Proteins c-akt - metabolism Regeneration Regeneration (Biology) Regeneration - drug effects Regeneration - genetics Satellite Cells, Skeletal Muscle - drug effects Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology Satellite Cells, Skeletal Muscle - transplantation Signal Transduction Skeletal muscle Stem Cell Niche Stem cell transplantation Stem Cells Tissue engineering Transcription
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