Parkinson disease and the gut: new insights into pathogenesis and clinical relevance

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe prodromal, non-motor dysfunctions that affect the quality of life of patients who subsequently develop PD. These prodro...

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Veröffentlicht in:	Nature reviews. Gastroenterology & hepatology 2020-11, Vol.17 (11), p.673-685
Hauptverfasser:	Travagli, R. Alberto, Browning, Kirsteen N., Camilleri, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects 692/699/375 Animal models Animals Axons Biomedicine Brain - physiopathology Care and treatment Central nervous system Complications and side effects Constipation Diagnosis Digestive system Disease Models, Animal Dopamine receptors Dopaminergic mechanisms Dysphagia Enteric nervous system Enteric Nervous System - physiopathology Gastric emptying Gastric motility Gastroenterology Gastrointestinal diseases Gastrointestinal Diseases - diagnosis Gastrointestinal Diseases - microbiology Gastrointestinal Diseases - therapy Gastrointestinal Microbiome - physiology Gastrointestinal tract Gastrointestinal Tract - innervation Gastrointestinal Tract - microbiology Gastrointestinal Tract - physiopathology Health aspects Hepatology Humans Lewy bodies Medicine Medicine & Public Health Movement disorders Nervous system Neurodegenerative diseases Neurotoxins - adverse effects Oxidopamine - adverse effects Parkinson Disease - etiology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - microbiology Parkinson Disease, Secondary - physiopathology Parkinson's disease Pathogenesis Pesticides - adverse effects Quality of life Review Article Substantia nigra Synuclein Vagus nerve
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