Interleukin-35 Suppresses CD8+ T Cell Activity in Patients with Viral Hepatitis-Induced Acute-on-Chronic Liver Failure

Background Interleukin (IL)-35 is a newly indentified cytokine and induces immunotolerance via suppression of CD8 + T cell activity in chronic viral hepatitis. Aims To investigate the modulatory function of IL-35 to CD8 + T cells in viral hepatitis-induced acute-on-chronic liver failure (ACLF). Meth...

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Veröffentlicht in:	Digestive diseases and sciences 2020-12, Vol.65 (12), p.3614-3623
Hauptverfasser:	Yang, Lanlan, Zhang, Qian, Song, Jie, Wang, Wudong, Jin, Zhenjing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-On-Chronic Liver Failure - blood Acute-On-Chronic Liver Failure - immunology Bilirubin - blood Biochemistry CD8-Positive T-Lymphocytes - immunology Coculture Techniques - methods Cytokines Cytotoxicity Cytotoxicity Tests, Immunologic - methods Female Gastroenterology Hep G2 Cells Hepatitis Hepatitis, Viral, Human - blood Hepatitis, Viral, Human - immunology Hepatology Humans Immune Tolerance Interleukins - blood Interleukins - immunology Lymphocyte Activation - immunology Lymphocytes Male Medicine Medicine & Public Health Middle Aged Oncology Original Article Prothrombin Time - methods Recombinant Proteins - blood Recombinant Proteins - immunology Transplant Surgery
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