EWSR1‐CREM fusion in pulmonary mesenchymal neoplasm showing distinctive clear cell morphology

EWSR1‐CREM gene fusions were recently discovered in several mesenchymal and epithelial tumors, including myxoid mesenchymal tumors of the central nervous system, rare cases of soft tissue clear cell sarcoma and angiomatoid fibrous histiocytoma, and hyalinizing clear cell carcinoma, which implicates...

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Veröffentlicht in:	Pathology international 2020-12, Vol.70 (12), p.1020-1026
Hauptverfasser:	Komatsu, Masato, Sakai, Yasuhiro, Nishikubo, Megumi, Tane, Shinya, Nishio, Wataru, Kajimoto, Kazuyoshi, Hirose, Takanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Alveoli Cell morphology Central nervous system Clear cells CREM Cyclic AMP response element modulator Cytology Desmin EWSR1 FLI-1 protein Fluorescence Fluorescence in situ hybridization fusion gene Gene sequencing Histiocytoma Inhibin Keratin Markers Mesenchyme Metastases Morphology Muscles Polymerase chain reaction pulmonary tumor Reverse transcription Ribonucleic acid RNA Sarcoma Smooth muscle Soft tissues Synaptophysin Tumor cells Tumors Vimentin
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