HIV-related cardiovascular disease: any role for high-density lipoproteins?
The introduction of antiretroviral therapy (ART) has improved the life expectancy of patients infected with human immunodeficiency virus (HIV). However, this population is at an increased risk for noncommunicable diseases, including atherosclerotic cardiovascular disease (CVD). Both ART and viral in...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2020-12, Vol.319 (6), p.H1221-H1226 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Hudson, Peter Woudberg, Nicholas J. Kamau, Festus Strijdom, Hans Frias, Miguel A. Lecour, Sandrine |
| description | The introduction of antiretroviral therapy (ART) has improved the life expectancy of patients infected with human immunodeficiency virus (HIV). However, this population is at an increased risk for noncommunicable diseases, including atherosclerotic cardiovascular disease (CVD). Both ART and viral infection may be potential contributors to the pathophysiology of HIV-related CVD. The mechanisms behind this remain unclear, but it is critical to delineate early biomarkers of cardiovascular risk in the HIV population. In this review, we postulate that potential biomarkers could include alterations to high-density lipoprotein (HDL). Indeed, recent data suggest that HIV and ART may induce structural changes of HDL, thus resulting in shifts in HDL subclass distribution and HDL functionality. |
| doi_str_mv | 10.1152/ajpheart.00445.2020 |
| format | Article |
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However, this population is at an increased risk for noncommunicable diseases, including atherosclerotic cardiovascular disease (CVD). Both ART and viral infection may be potential contributors to the pathophysiology of HIV-related CVD. The mechanisms behind this remain unclear, but it is critical to delineate early biomarkers of cardiovascular risk in the HIV population. In this review, we postulate that potential biomarkers could include alterations to high-density lipoprotein (HDL). Indeed, recent data suggest that HIV and ART may induce structural changes of HDL, thus resulting in shifts in HDL subclass distribution and HDL functionality.</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00445.2020</identifier><identifier>PMID: 33006917</identifier><language>eng</language><publisher>BETHESDA: Amer Physiological Soc</publisher><subject>Africa South of the Sahara - epidemiology ; Anti-HIV Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral therapy ; Arteriosclerosis ; Atherosclerosis ; Biomarkers ; Biomarkers - blood ; Cardiac & Cardiovascular Systems ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular System & Cardiology ; Density ; Dyslipidemias - blood ; Dyslipidemias - diagnosis ; Dyslipidemias - epidemiology ; Health risks ; Heart Disease Risk Factors ; Heart diseases ; High density lipoprotein ; HIV ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Long-Term Survivors ; Human immunodeficiency virus ; Humans ; Life expectancy ; Life Sciences & Biomedicine ; Life span ; Lipoproteins ; Lipoproteins, HDL - blood ; Peripheral Vascular Disease ; Physiology ; Prognosis ; Risk Assessment ; Science & Technology</subject><ispartof>American journal of physiology. 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Heart and circulatory physiology</title><addtitle>AM J PHYSIOL-HEART C</addtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>The introduction of antiretroviral therapy (ART) has improved the life expectancy of patients infected with human immunodeficiency virus (HIV). However, this population is at an increased risk for noncommunicable diseases, including atherosclerotic cardiovascular disease (CVD). Both ART and viral infection may be potential contributors to the pathophysiology of HIV-related CVD. The mechanisms behind this remain unclear, but it is critical to delineate early biomarkers of cardiovascular risk in the HIV population. In this review, we postulate that potential biomarkers could include alterations to high-density lipoprotein (HDL). Indeed, recent data suggest that HIV and ART may induce structural changes of HDL, thus resulting in shifts in HDL subclass distribution and HDL functionality.</description><subject>Africa South of the Sahara - epidemiology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral therapy</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular System & Cardiology</subject><subject>Density</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - diagnosis</subject><subject>Dyslipidemias - epidemiology</subject><subject>Health risks</subject><subject>Heart Disease Risk Factors</subject><subject>Heart diseases</subject><subject>High density lipoprotein</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Long-Term Survivors</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Life Sciences & Biomedicine</subject><subject>Life span</subject><subject>Lipoproteins</subject><subject>Lipoproteins, HDL - blood</subject><subject>Peripheral Vascular Disease</subject><subject>Physiology</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Science & Technology</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUFrFDEUx0NR7Fr9BAUZ8CLIrEneTDLppZRFbbHQS_U6ZJIXN8vsZJtklP32Zt22B0-e8iC__3svvxByzuiSsZZ_0pvdGnXMS0qbpl1yyukJWZQbXrMW1AuyoCCgFgzaU_I6pQ2ltJUCXpFTAEqFYnJBvl3f_KgjjjqjrYyO1odfOpl51LGyPqFOeFHpaV_FMGLlQqzW_ue6tjgln_fV6HdhF0NGP6XLN-Sl02PCt4_nGfn-5fP96rq-vft6s7q6rQ0A5FpL4To2OKakpkJKrTowvONUIaBqHForDG0cGyw453Q7CCUBJQPbasUZnJEPx75l8sOMKfdbnwyOo54wzKnnTdM1h_cd0Pf_oJswx6lsVyhJhVCd4oWCI2ViSCmi63fRb3Xc94z2B9f9k-v-r-v-4Lqk3j32noct2ufMk9wCdEfgNw7BJeNxMviMld8QXErJ21JRtvJZZx-mVZinXKIf_z8KfwDQCpxr</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Hudson, Peter</creator><creator>Woudberg, Nicholas J.</creator><creator>Kamau, Festus</creator><creator>Strijdom, Hans</creator><creator>Frias, Miguel A.</creator><creator>Lecour, Sandrine</creator><general>Amer Physiological Soc</general><general>American Physiological Society</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3726-9153</orcidid><orcidid>https://orcid.org/0000-0001-6884-4793</orcidid><orcidid>https://orcid.org/0000-0003-1942-8974</orcidid></search><sort><creationdate>20201201</creationdate><title>HIV-related cardiovascular disease: any role for high-density lipoproteins?</title><author>Hudson, Peter ; 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Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hudson, Peter</au><au>Woudberg, Nicholas J.</au><au>Kamau, Festus</au><au>Strijdom, Hans</au><au>Frias, Miguel A.</au><au>Lecour, Sandrine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV-related cardiovascular disease: any role for high-density lipoproteins?</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><stitle>AM J PHYSIOL-HEART C</stitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>319</volume><issue>6</issue><spage>H1221</spage><epage>H1226</epage><pages>H1221-H1226</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>The introduction of antiretroviral therapy (ART) has improved the life expectancy of patients infected with human immunodeficiency virus (HIV). However, this population is at an increased risk for noncommunicable diseases, including atherosclerotic cardiovascular disease (CVD). Both ART and viral infection may be potential contributors to the pathophysiology of HIV-related CVD. The mechanisms behind this remain unclear, but it is critical to delineate early biomarkers of cardiovascular risk in the HIV population. In this review, we postulate that potential biomarkers could include alterations to high-density lipoprotein (HDL). Indeed, recent data suggest that HIV and ART may induce structural changes of HDL, thus resulting in shifts in HDL subclass distribution and HDL functionality.</abstract><cop>BETHESDA</cop><pub>Amer Physiological Soc</pub><pmid>33006917</pmid><doi>10.1152/ajpheart.00445.2020</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3726-9153</orcidid><orcidid>https://orcid.org/0000-0001-6884-4793</orcidid><orcidid>https://orcid.org/0000-0003-1942-8974</orcidid></addata></record> |
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| subjects | Africa South of the Sahara - epidemiology Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral therapy Arteriosclerosis Atherosclerosis Biomarkers Biomarkers - blood Cardiac & Cardiovascular Systems Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular System & Cardiology Density Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - epidemiology Health risks Heart Disease Risk Factors Heart diseases High density lipoprotein HIV HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - epidemiology HIV Long-Term Survivors Human immunodeficiency virus Humans Life expectancy Life Sciences & Biomedicine Life span Lipoproteins Lipoproteins, HDL - blood Peripheral Vascular Disease Physiology Prognosis Risk Assessment Science & Technology |
| title | HIV-related cardiovascular disease: any role for high-density lipoproteins? |
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