Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model

•Blood NAD and Sirt1 are low in GW veterans with GWI.•Treatment with NR increased NAD and alleviated fatigue-like behavior in a mouse model of GWI.•Consistent with human GWI, blood NAD and Sirt1 are low in our mouse model of GWI.•Brain NAD levels were normal in GWI mice but are increased in both GWI...

Ausführliche Beschreibung