$Evinacumab in Patients with Refractory Hypercholesterolemia$

Evinacumab in Patients with Refractory Hypercholesterolemia

Angiopoietin-like 3 is an inhibitor of lipoprotein lipase. Evinacumab is a monoclonal antibody that inhibits angiopoietin-like 3, activating lipoprotein lipase. In patients with hypercholesterolemia that is refractory to statin and PCSK9 inhibitor therapy, the use of evinacumab reduced plasma lipid...

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Veröffentlicht in:	The New England journal of medicine 2020-12, Vol.383 (24), p.2307-2319
Hauptverfasser:	Rosenson, Robert S, Burgess, Lesley J, Ebenbichler, Christoph F, Baum, Seth J, Stroes, Erik S.G, Ali, Shazia, Khilla, Nagwa, Hamlin, Robert, Pordy, Robert, Dong, Yuping, Son, Vladimir, Gaudet, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiopoietin Angiopoietin-like Proteins - antagonists & inhibitors Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - adverse effects Anticholesteremic Agents - therapeutic use Arteriosclerosis Body weight Cardiology Cardiovascular disease Cholesterol Cholesterol, LDL - blood Coronary vessels Double-Blind Method Drug Administration Schedule Drug Resistance Female Humans Hypercholesterolemia Hyperlipoproteinemia Type II - drug therapy Infusions, Intravenous Injections, Subcutaneous Intravenous administration Lipids Low density lipoprotein Male Middle Aged Monoclonal antibodies Mutation Statins
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