Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells
Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pa...
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| Veröffentlicht in: | Food and agricultural immunology 2020-01, Vol.31 (1), p.193-204 |
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| creator | Lee, Hsiang-Ping Wang, Shih-Wei Wu, Yang-Chang Lin, Liang-Wei Tsai, Fuu-Jen Yang, Jai-Sing Li, Te-Mao Tang, Chih-Hsin |
| description | Vascular endothelial growth factor (VEGF) is well recognized as an essential component of angiogenesis and the increased proliferation and migration of endothelial cells. Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pathological states. Soya-cerebroside, an extract from Cordyceps militaris, reduces synovial inflammation and prevents cartilage damage in an osteoarthritis model. However, the role of soya-cerebroside in VEGF-regulated EPC angiogenesis is uncertain. Records from the Oncomine database demonstrate higher levels of VEGF in cancerous tissue compared with normal tissue. This study describes VEGF-induced promotion of EPC-associated angiogenesis in vivo and how the treatment of EPCs with soya-cerebroside inhibited VEGF-facilitated migration and tube formation. The study evidence shows that the c-Src, FAK and Runx2 signalling pathways are involved in the inhibitory effects of soya-cerebroside. This novel agent may therefore be used to inhibit EPC-associated angiogenesis. |
| doi_str_mv | 10.1080/09540105.2020.1713055 |
| format | Article |
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Bone marrow-derived endothelial progenitor cells (EPCs) are involved in VEGF-induced vessel formation during physiological and pathological states. Soya-cerebroside, an extract from Cordyceps militaris, reduces synovial inflammation and prevents cartilage damage in an osteoarthritis model. However, the role of soya-cerebroside in VEGF-regulated EPC angiogenesis is uncertain. Records from the Oncomine database demonstrate higher levels of VEGF in cancerous tissue compared with normal tissue. This study describes VEGF-induced promotion of EPC-associated angiogenesis in vivo and how the treatment of EPCs with soya-cerebroside inhibited VEGF-facilitated migration and tube formation. The study evidence shows that the c-Src, FAK and Runx2 signalling pathways are involved in the inhibitory effects of soya-cerebroside. This novel agent may therefore be used to inhibit EPC-associated angiogenesis.</description><identifier>ISSN: 0954-0105</identifier><identifier>EISSN: 1465-3443</identifier><identifier>DOI: 10.1080/09540105.2020.1713055</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis</publisher><subject>Angiogenesis ; Biomedical materials ; Blood vessels ; Bone marrow ; Cartilage ; Cartilage diseases ; Cbfa-1 protein ; Cell migration ; Cell proliferation ; Damage prevention ; Endothelial cells ; endothelial progenitor cells ; Growth factors ; In vivo methods and tests ; Osteoarthritis ; Osteoprogenitor cells ; Progenitor cells ; Signal transduction ; Soya-cerebroside ; Src protein ; Vascular endothelial growth factor ; Vascular endothelial growth factor receptors ; VEGF</subject><ispartof>Food and agricultural immunology, 2020-01, Vol.31 (1), p.193-204</ispartof><rights>2020 The Author(s). Published with license by Taylor and Francis Group, LLC 2020</rights><rights>2020 The Author(s). Published with license by Taylor and Francis Group, LLC. This work is licensed under the Creative Commons Attribution – Non-Commercial – No Derivatives License http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). 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This novel agent may therefore be used to inhibit EPC-associated angiogenesis.</description><subject>Angiogenesis</subject><subject>Biomedical materials</subject><subject>Blood vessels</subject><subject>Bone marrow</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Cbfa-1 protein</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Damage prevention</subject><subject>Endothelial cells</subject><subject>endothelial progenitor cells</subject><subject>Growth factors</subject><subject>In vivo methods and tests</subject><subject>Osteoarthritis</subject><subject>Osteoprogenitor cells</subject><subject>Progenitor cells</subject><subject>Signal transduction</subject><subject>Soya-cerebroside</subject><subject>Src protein</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular endothelial growth factor receptors</subject><subject>VEGF</subject><issn>0954-0105</issn><issn>1465-3443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>DOA</sourceid><recordid>eNp9kctuHCEQRVGUSBk7-YRILWXdDsWrm10iyy_Jkhd2kiWqBnrMCDcOYEXz96YztpdZIapO3bpwCfkC9AToSL9RLQUFKk8YZa00AKdSviMbEEr2XAj-nmxWpl-hj-SolB2lVCgtN-T3bdpjb332U04lON-F5T5MoZbu19nFeT-jDTFUrN51uGxD2vrFl1Aa1vnFpXrvY8DYPea1E2rKnfUxlk_kw4yx-M8v5zH5eX52d3rZX99cXJ3-uO6tkFD72SsKigFKRBTtpnBQYkBkCNBMDqjEKJRyHEY-64ExqqdJTB4YF9YyfkyuDrou4c485vCAeW8SBvOvkPLWYK7BRm-olxxh1oxrEAMV6GBimlmntdDOrVpfD1rtMX-efKlml57y0uwbJtQopdQjNEoeKNs-rGQ_v20FatY8zGseZs3DvOTR5r4f5sIyp_yAf1OOzlTcx5TnjIsNxfD_SzwDfHCQVw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Lee, Hsiang-Ping</creator><creator>Wang, Shih-Wei</creator><creator>Wu, Yang-Chang</creator><creator>Lin, Liang-Wei</creator><creator>Tsai, Fuu-Jen</creator><creator>Yang, Jai-Sing</creator><creator>Li, Te-Mao</creator><creator>Tang, Chih-Hsin</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7113-8352</orcidid></search><sort><creationdate>20200101</creationdate><title>Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells</title><author>Lee, Hsiang-Ping ; 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| subjects | Angiogenesis Biomedical materials Blood vessels Bone marrow Cartilage Cartilage diseases Cbfa-1 protein Cell migration Cell proliferation Damage prevention Endothelial cells endothelial progenitor cells Growth factors In vivo methods and tests Osteoarthritis Osteoprogenitor cells Progenitor cells Signal transduction Soya-cerebroside Src protein Vascular endothelial growth factor Vascular endothelial growth factor receptors VEGF |
| title | Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells |
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