Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy
New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. First, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3‐aminomethyl‐pyridineamido)‐26,28‐dihydroxycalix[4]arene (3‐AMP) scaffold was produced by electrospinning. AMP scaffold was modified...
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| Veröffentlicht in: | Journal of applied polymer science 2021-03, Vol.138 (11), p.n/a |
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| creator | Ozcan, Fatih Cagil, Esra Maltas |
| description | New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. First, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3‐aminomethyl‐pyridineamido)‐26,28‐dihydroxycalix[4]arene (3‐AMP) scaffold was produced by electrospinning. AMP scaffold was modified by human serum albumin (HSA), folic acid (FA), and glutathione (GSH). Doxorubicin (DOX) was loaded to surfaces of the AMP, AMP‐HSA, AMP‐HSA‐FA, and AMP‐HSA‐GSH nanofibers by using DOX solution in different buffers with, 2.2, 4.0, 6.0, and 7.4 pH. The release studies DOX from four different nanofibers was also done in a various amount microenviroments by changing pH values. The loading and release amount of DOX was estimated from the calibration curve drawn at 480 and 560 nm of excitation and emission wavelengths by using a fluorescence spectrophotometer. The loading studies were confirmed by Fourier transforms infrared, atomic force microscopy, transmission electron microscopy, scanning electron microscope, and energy‐dispersive X‐ray (EDX) analysis. |
| doi_str_mv | 10.1002/app.50041 |
| format | Article |
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First, 5,11,17,23‐tetra‐tert‐butyl‐25,27‐bis(3‐aminomethyl‐pyridineamido)‐26,28‐dihydroxycalix[4]arene (3‐AMP) scaffold was produced by electrospinning. AMP scaffold was modified by human serum albumin (HSA), folic acid (FA), and glutathione (GSH). Doxorubicin (DOX) was loaded to surfaces of the AMP, AMP‐HSA, AMP‐HSA‐FA, and AMP‐HSA‐GSH nanofibers by using DOX solution in different buffers with, 2.2, 4.0, 6.0, and 7.4 pH. The release studies DOX from four different nanofibers was also done in a various amount microenviroments by changing pH values. The loading and release amount of DOX was estimated from the calibration curve drawn at 480 and 560 nm of excitation and emission wavelengths by using a fluorescence spectrophotometer. The loading studies were confirmed by Fourier transforms infrared, atomic force microscopy, transmission electron microscopy, scanning electron microscope, and energy‐dispersive X‐ray (EDX) analysis.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.50041</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Atomic force microscopy ; biomedical applications ; Calixarenes ; Doxorubicin ; Drug delivery systems ; Electron microscopes ; electrospinning ; Emission analysis ; Fluorescence ; Folic acid ; Fourier transforms ; Glutathione ; Materials science ; Microscopy ; Nanofibers ; Polymers ; Scaffolds ; Serum albumin ; stimuli‐sensitive polymers</subject><ispartof>Journal of applied polymer science, 2021-03, Vol.138 (11), p.n/a</ispartof><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3341-3beb4c59ace00437a402d8494b120f2a9094af32aac072544babb57d0d29b7563</citedby><cites>FETCH-LOGICAL-c3341-3beb4c59ace00437a402d8494b120f2a9094af32aac072544babb57d0d29b7563</cites><orcidid>0000-0001-7574-6016 ; 0000-0002-3922-7902</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.50041$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.50041$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Ozcan, Fatih</creatorcontrib><creatorcontrib>Cagil, Esra Maltas</creatorcontrib><title>Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy</title><title>Journal of applied polymer science</title><description>New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. 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The loading studies were confirmed by Fourier transforms infrared, atomic force microscopy, transmission electron microscopy, scanning electron microscope, and energy‐dispersive X‐ray (EDX) analysis.</description><subject>Atomic force microscopy</subject><subject>biomedical applications</subject><subject>Calixarenes</subject><subject>Doxorubicin</subject><subject>Drug delivery systems</subject><subject>Electron microscopes</subject><subject>electrospinning</subject><subject>Emission analysis</subject><subject>Fluorescence</subject><subject>Folic acid</subject><subject>Fourier transforms</subject><subject>Glutathione</subject><subject>Materials science</subject><subject>Microscopy</subject><subject>Nanofibers</subject><subject>Polymers</subject><subject>Scaffolds</subject><subject>Serum albumin</subject><subject>stimuli‐sensitive polymers</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kD1Pw0AMhk8IJEph4B-cxMQQuLtckh4b4qtIlWCAOXISJ72q-cCXgMLEyMhv5JdwpawstmQ_9mu_jB1LcSaFUOfQdWeREFrusIkUJgl0rGa7bOJ7MpgZE-2zA-dWQkgZiXjCPq_R2arh0BQ8XwJB3iPZd-ht2_C25N2cu97Ww9p-f3wRuq5tnH1F3kDTljZD4gUNFS9w7as0cje6HusL_rRE3lFbW2ebivdAFfboJYDIIjletsT7od7EJRJ04yHbK2Ht8OgvT9nz7c3T1TxYPNzdX10ugjwMtQzCDDOdRwZy9F-GCWihipk2OpNKlAqMMBrKUAHkIlGR1hlkWZQUolAmS6I4nLKT7V5_3cuArk9X7UCNl0yVjv2mZGYiT51uqZxa5wjLtCNbA42pFOnG6NQbnf4a7dnzLftm1zj-D6aXj4_biR9S6oMu</recordid><startdate>20210315</startdate><enddate>20210315</enddate><creator>Ozcan, Fatih</creator><creator>Cagil, Esra Maltas</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-7574-6016</orcidid><orcidid>https://orcid.org/0000-0002-3922-7902</orcidid></search><sort><creationdate>20210315</creationdate><title>Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy</title><author>Ozcan, Fatih ; Cagil, Esra Maltas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3341-3beb4c59ace00437a402d8494b120f2a9094af32aac072544babb57d0d29b7563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Atomic force microscopy</topic><topic>biomedical applications</topic><topic>Calixarenes</topic><topic>Doxorubicin</topic><topic>Drug delivery systems</topic><topic>Electron microscopes</topic><topic>electrospinning</topic><topic>Emission analysis</topic><topic>Fluorescence</topic><topic>Folic acid</topic><topic>Fourier transforms</topic><topic>Glutathione</topic><topic>Materials science</topic><topic>Microscopy</topic><topic>Nanofibers</topic><topic>Polymers</topic><topic>Scaffolds</topic><topic>Serum albumin</topic><topic>stimuli‐sensitive polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozcan, Fatih</creatorcontrib><creatorcontrib>Cagil, Esra Maltas</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozcan, Fatih</au><au>Cagil, Esra Maltas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy</atitle><jtitle>Journal of applied polymer science</jtitle><date>2021-03-15</date><risdate>2021</risdate><volume>138</volume><issue>11</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>New carrier platforms have been designed for an electrospun pyridinium calixarene nanofiber for controlled drug delivery. 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| language | eng |
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| subjects | Atomic force microscopy biomedical applications Calixarenes Doxorubicin Drug delivery systems Electron microscopes electrospinning Emission analysis Fluorescence Folic acid Fourier transforms Glutathione Materials science Microscopy Nanofibers Polymers Scaffolds Serum albumin stimuli‐sensitive polymers |
| title | Design and characterization of pH stimuli‐responsive nanofiber drug delivery system: The promising targeted carriers for tumor therapy |
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