Polycyclic polyprenylated acylphloroglucinols with acetylcholinesterase inhibitory activities from Hypericum perforatum

Six new polycyclic polyprenylated acylphloroglucinols, hyperfols CH (1–6), along with seven known ones (7–13), were isolated from the aerial parts of Hypericum perforatum. The structures were identified on the basis of comprehensive spectroscopic data analysis including 1D and 2D NMR, and the absolu...

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Veröffentlicht in:	Fitoterapia 2020-06, Vol.143, p.104550-6, Article 104550
Hauptverfasser:	Lou, Huayong, Yi, Ping, Hu, Zhanxing, Li, Yanan, Zeng, Yanrong, Gu, Wei, Huang, Liejun, Yuan, Chunmao, Hao, Xiaojiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase inhibitory activities China Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Circular Dichroism Data analysis Dichroism Hypericum Hypericum - chemistry Hypericum perforatum Magnetic Resonance Spectroscopy Molecular Structure NMR Nuclear magnetic resonance Phloroglucinol - isolation & purification Phloroglucinol - pharmacology Phytochemicals - isolation & purification Phytochemicals - pharmacology Plant Components, Aerial - chemistry Polycyclic polyprenylated acylphloroglucinols Quantum chemistry Two dimensional analysis
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Zusammenfassung:	Six new polycyclic polyprenylated acylphloroglucinols, hyperfols CH (1–6), along with seven known ones (7–13), were isolated from the aerial parts of Hypericum perforatum. The structures were identified on the basis of comprehensive spectroscopic data analysis including 1D and 2D NMR, and the absolute configurations of the new compounds were determined by quantum chemical electronic circular dichroism (ECD) calculations. In addition, compounds 4 and 12 exhibited moderate acetylcholinesterase (AChE) inhibitory activities, with IC50 values of 20.32 and 27.37 μM, respectively. [Display omitted]
ISSN:	0367-326X 1873-6971
DOI:	10.1016/j.fitote.2020.104550