Anti-Alzheimer's flavanolignans from Ceiba pentandra aerial parts

Four flavanolignans, ceibapentains A (1) and B (2) and cinchonains Ia (3) and Ib (4), were isolated for the first time from an ethyl acetate extract of Ceiba pentandra (L) (Bombacaceae) aerial parts. The ceibapentains A (1) and B (2) are new compounds and their structures, including the absolute con...

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Veröffentlicht in:	Fitoterapia 2020-06, Vol.143, p.104541-7, Article 104541
Hauptverfasser:	Abouelela, Mohamed E., Orabi, Mohamed A.A., Abdelhamid, Reda A., Abdelkader, Mohamed S.A., Darwish, Faten M.M., Hotsumi, Mayumi, Konno, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Alzheimer's disease Amyloid beta-Peptides - antagonists & inhibitors Amyloid β42 Anti-Alzheimer's Bombacaceae Ceiba - chemistry Ceiba pentandra Ceibapentains Circular Dichroism Curcumin Dichroism Egypt Ethyl acetate Flavanolignan Flavonolignans - isolation & purification Flavonolignans - pharmacology Humans Molecular docking Molecular Docking Simulation Molecular Structure Neurodegenerative diseases NMR Nuclear magnetic resonance Peptide Fragments - antagonists & inhibitors Peptides Phytochemicals - isolation & purification Phytochemicals - pharmacology Plant Components, Aerial - chemistry Plant Extracts - chemistry Two dimensional analysis β-Amyloid
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