Fibrosis regression is induced by AdhMMP8 in a murine model of chronic kidney injury

Adenoviral vector AdhMMP8 (human Metalloproteinase-8 cDNA) administration has been proven beneficial in various experimental models of liver injury improving liver function and decreasing fibrosis. In this study, we evaluated the potential therapeutic AdhMMP8 effect in a chronic kidney damage experi...

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Veröffentlicht in:	PloS one 2020-12, Vol.15 (12), p.e0243307, Article 0243307
Hauptverfasser:	Contreras-Salinas, Homero, Meza-Rios, Alejandra, Garcia-Banuelos, Jesus, Sandoval-Rodriguez, Ana, Sanchez-Orozco, Laura, Garcia-Benavides, Leonel, De la Rosa-Bibiano, Ricardo, Monroy Ramirez, Hugo Christian, Gutierrez-Cuevas, Jorge, Santos-Garcia, Arturo, Armendariz-Borunda, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenine - adverse effects Adenine - pharmacology Adenoviridae Adenoviruses Animal models Animals Atrophy Biology and Life Sciences Chronic kidney failure Connective tissue growth factor Creatinine Development and progression Disease Models, Animal Fibrosis Gene expression Gene Expression Regulation Gene regulation Gene therapy Genetic aspects Genomics Health care Health sciences HEK293 Cells Histology Histopathology Humans Injuries Interleukin 1 Ischemia Kidney diseases Kidney Failure, Chronic - chemically induced Kidney Failure, Chronic - genetics Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Kidneys Liver Male Matrix Metalloproteinase 8 - biosynthesis Matrix Metalloproteinase 8 - genetics Medicine Medicine and Health Sciences Metalloproteinase Molecular biology Mortality Multidisciplinary Sciences Neutrophil collagenase Pax2 protein Rats Rats, Wistar Regression (Disease) Regression analysis Science & Technology Science & Technology - Other Topics Transduction, Genetic Transforming growth factor-b1 Transplants & implants Tumor necrosis factor-α Vascular endothelial growth factor Vectors (Biology) Veins & arteries
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