Clinicopathological features and immunohistochemical utility of NTRK-, ALK-, and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas

NTRK1/3, ALK, and ROS1 translocations have been reported in a minor subset of papillary thyroid carcinomas (PTCs). We aimed to elucidate the prevalence and clinicopathological characteristics of these gene rearrangements and the utility of immunohistochemistry (IHC) in PTC and anaplastic thyroid car...

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Veröffentlicht in:	Human pathology 2020-12, Vol.106, p.82-92
Hauptverfasser:	Nozaki, Yui, Yamamoto, Hidetaka, Iwasaki, Takeshi, Sato, Masanobu, Jiromaru, Rina, Hongo, Takahiro, Yasumatsu, Ryuji, Oda, Yoshinao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over ALK Anaplastic Lymphoma Kinase - genetics Anaplastic thyroid carcinoma Antibodies Biomarkers, Tumor - genetics Female Gene Rearrangement Genetic Predisposition to Disease Humans Immunohistochemistry In Situ Hybridization, Fluorescence Kinases Male Middle Aged Mutation NTRK pan-Trk Papillary thyroid carcinoma Phenotype Predictive Value of Tests Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Receptor, trkA - genetics Receptor, trkC - genetics Reproducibility of Results ROS1 Thyroid cancer Thyroid Cancer, Papillary - genetics Thyroid Cancer, Papillary - pathology Thyroid Carcinoma, Anaplastic - genetics Thyroid Carcinoma, Anaplastic - pathology Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Tumors Young Adult
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