Serotonin and the 5‐ HT 7 receptor: The link between hepatocytes, IGF ‐1 and small intestinal neuroendocrine tumors

Platelet‐derived serotonin (5‐ HT ) is involved in liver regeneration. The liver is also the metastatic site for malignant enterochromaffin ( EC ) cell “carcinoid” (neuroendocrine) neoplasms, the principal cellular source of 5‐ HT . We hypothesized that 5‐ HT produced by metastatic EC cells played a...

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Veröffentlicht in:	Cancer science 2013-07, Vol.104 (7), p.844-855
Hauptverfasser:	Svejda, Bernhard, Kidd, Mark, Timberlake, Andrew, Harry, Kathy, Kazberouk, Alexander, Schimmack, Simon, Lawrence, Ben, Pfragner, Roswitha, Modlin, Irvin M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibodies Collagen Cyclic AMP response element-binding protein Experiments Growth factors Hepatocytes Insulin-like growth factors Intestine Liver Metastases Metastasis Neoplasia Neuroendocrine tumors Penicillin Physiology Protein kinase A Proteins Regeneration Secretion Serotonin Transfection Tumors Western blotting
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