Oxido‐inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes
Petroleum products—petrol, kerosene, and diesel—composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation‐related predisposition to respiratory toxicity and disease pathogenesis. We s...
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| Veröffentlicht in: | Environmental toxicology 2021-01, Vol.36 (1), p.132-143 |
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| creator | Owumi, Solomon E. Elebiyo, Tobiloba C. Oladimeji, Bidemi Noah |
| description | Petroleum products—petrol, kerosene, and diesel—composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation‐related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposure to PPF inhalation and examined their effect on oxido‐inflammatory responses, toxicity, and histopathological alterations in rat lungs, following 8‐hours daily exposure for 60 and 90 days. Reactive oxygen and nitrogen species (RONS), oxidative stress and inflammatory biomarkers, namely: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), TNF‐α, IL‐1β, xanthine oxidase (XO), nitric oxide (NO) activity were evaluated. Besides, histopathological examination of the lungs and trachea of exposed rats, PPF exposure resulted in significant (P |
| doi_str_mv | 10.1002/tox.23019 |
| format | Article |
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Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation‐related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposure to PPF inhalation and examined their effect on oxido‐inflammatory responses, toxicity, and histopathological alterations in rat lungs, following 8‐hours daily exposure for 60 and 90 days. Reactive oxygen and nitrogen species (RONS), oxidative stress and inflammatory biomarkers, namely: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), TNF‐α, IL‐1β, xanthine oxidase (XO), nitric oxide (NO) activity were evaluated. Besides, histopathological examination of the lungs and trachea of exposed rats, PPF exposure resulted in significant (P < .05) increases in RONS, biomarkers of oxidative stress, pro‐inflammation cytokines, and reduced (P < .05) GSH levels in rats, secondary to histopathological alteration in lungs and trachea cytoarchitecture examined in an exposure‐duration‐dependent manner. We conclude, therefore, that the observed biochemical and histological changes create a microenvironment that is permissive to diseases pathogenesis of the respiratory system via oxido‐inflammatory mechanistic pathways.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.23019</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Air pollution ; Biological stress ; Biomarkers ; Cytokines ; Exposure ; Fumes ; Gasoline ; Glutathione ; Glutathione peroxidase ; Histopathology ; Inflammation ; Inhalation ; Kerosene ; Lungs ; Nitric oxide ; occupational exposure ; Organic constituents ; Oxidative stress ; oxido‐inflammatory responses ; Pathogenesis ; Peroxidase ; Petroleum ; petroleum product fumes ; Petroleum products ; Reactive nitrogen species ; Reactive oxygen species ; Respiration ; Respiratory system ; respiratory toxicity ; RONS ; Service stations ; Superoxide dismutase ; Toxic diseases ; Toxicity ; Trachea ; Tumor necrosis factor ; Xanthine oxidase</subject><ispartof>Environmental toxicology, 2021-01, Vol.36 (1), p.132-143</ispartof><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2829-50374c32ceb09abb4c4b25de570fc22278adb655fe456f64d5dca3774b242bef3</citedby><cites>FETCH-LOGICAL-c2829-50374c32ceb09abb4c4b25de570fc22278adb655fe456f64d5dca3774b242bef3</cites><orcidid>0000-0002-4973-0376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.23019$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.23019$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Owumi, Solomon E.</creatorcontrib><creatorcontrib>Elebiyo, Tobiloba C.</creatorcontrib><creatorcontrib>Oladimeji, Bidemi Noah</creatorcontrib><title>Oxido‐inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes</title><title>Environmental toxicology</title><description>Petroleum products—petrol, kerosene, and diesel—composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation‐related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposure to PPF inhalation and examined their effect on oxido‐inflammatory responses, toxicity, and histopathological alterations in rat lungs, following 8‐hours daily exposure for 60 and 90 days. Reactive oxygen and nitrogen species (RONS), oxidative stress and inflammatory biomarkers, namely: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), TNF‐α, IL‐1β, xanthine oxidase (XO), nitric oxide (NO) activity were evaluated. Besides, histopathological examination of the lungs and trachea of exposed rats, PPF exposure resulted in significant (P < .05) increases in RONS, biomarkers of oxidative stress, pro‐inflammation cytokines, and reduced (P < .05) GSH levels in rats, secondary to histopathological alteration in lungs and trachea cytoarchitecture examined in an exposure‐duration‐dependent manner. We conclude, therefore, that the observed biochemical and histological changes create a microenvironment that is permissive to diseases pathogenesis of the respiratory system via oxido‐inflammatory mechanistic pathways.</description><subject>Air pollution</subject><subject>Biological stress</subject><subject>Biomarkers</subject><subject>Cytokines</subject><subject>Exposure</subject><subject>Fumes</subject><subject>Gasoline</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Histopathology</subject><subject>Inflammation</subject><subject>Inhalation</subject><subject>Kerosene</subject><subject>Lungs</subject><subject>Nitric oxide</subject><subject>occupational exposure</subject><subject>Organic constituents</subject><subject>Oxidative stress</subject><subject>oxido‐inflammatory responses</subject><subject>Pathogenesis</subject><subject>Peroxidase</subject><subject>Petroleum</subject><subject>petroleum product fumes</subject><subject>Petroleum products</subject><subject>Reactive nitrogen species</subject><subject>Reactive oxygen species</subject><subject>Respiration</subject><subject>Respiratory system</subject><subject>respiratory toxicity</subject><subject>RONS</subject><subject>Service stations</subject><subject>Superoxide dismutase</subject><subject>Toxic diseases</subject><subject>Toxicity</subject><subject>Trachea</subject><subject>Tumor necrosis factor</subject><subject>Xanthine oxidase</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kM1KAzEUhYMoWKsL3yDgysW0mUwyP0sR_6DQTQV3IZOfmpqZjEkG252P4DP6JMbWrat74H73Hs4B4DJHsxwhPI9uO8MFypsjMMkpxlmFq_p4r1FGUJ2fgrMQNgihpqTlBLwtt0a6788v02vLu45H53fQqzC4PqgAeS_hqwnRWbc2glvIbVSeR5PW0PQwSWjHfh2g2g4uKAmjg4OK3lk1dnDwTo4iQj12KpyDE81tUBd_cwqe7-9Wt4_ZYvnwdHuzyASucZNRVFREFFioFjW8bYkgLaZS0QppgXHKw2VbUqoVoaUuiaRS8KKqEkVwq3QxBVeHv8n9fVQhso0bfZ8sGSYlbWpMizxR1wdKeBeCV5oN3nTc71iO2G-XLHXJ9l0mdn5gP4xVu_9Btlq-HC5-AOApebs</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Owumi, Solomon E.</creator><creator>Elebiyo, Tobiloba C.</creator><creator>Oladimeji, Bidemi Noah</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-4973-0376</orcidid></search><sort><creationdate>202101</creationdate><title>Oxido‐inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes</title><author>Owumi, Solomon E. ; Elebiyo, Tobiloba C. ; Oladimeji, Bidemi Noah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2829-50374c32ceb09abb4c4b25de570fc22278adb655fe456f64d5dca3774b242bef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Air pollution</topic><topic>Biological stress</topic><topic>Biomarkers</topic><topic>Cytokines</topic><topic>Exposure</topic><topic>Fumes</topic><topic>Gasoline</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Histopathology</topic><topic>Inflammation</topic><topic>Inhalation</topic><topic>Kerosene</topic><topic>Lungs</topic><topic>Nitric oxide</topic><topic>occupational exposure</topic><topic>Organic constituents</topic><topic>Oxidative stress</topic><topic>oxido‐inflammatory responses</topic><topic>Pathogenesis</topic><topic>Peroxidase</topic><topic>Petroleum</topic><topic>petroleum product fumes</topic><topic>Petroleum products</topic><topic>Reactive nitrogen species</topic><topic>Reactive oxygen species</topic><topic>Respiration</topic><topic>Respiratory system</topic><topic>respiratory toxicity</topic><topic>RONS</topic><topic>Service stations</topic><topic>Superoxide dismutase</topic><topic>Toxic diseases</topic><topic>Toxicity</topic><topic>Trachea</topic><topic>Tumor necrosis factor</topic><topic>Xanthine oxidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Owumi, Solomon E.</creatorcontrib><creatorcontrib>Elebiyo, Tobiloba C.</creatorcontrib><creatorcontrib>Oladimeji, Bidemi Noah</creatorcontrib><collection>CrossRef</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Owumi, Solomon E.</au><au>Elebiyo, Tobiloba C.</au><au>Oladimeji, Bidemi Noah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxido‐inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes</atitle><jtitle>Environmental toxicology</jtitle><date>2021-01</date><risdate>2021</risdate><volume>36</volume><issue>1</issue><spage>132</spage><epage>143</epage><pages>132-143</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><abstract>Petroleum products—petrol, kerosene, and diesel—composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation‐related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposure to PPF inhalation and examined their effect on oxido‐inflammatory responses, toxicity, and histopathological alterations in rat lungs, following 8‐hours daily exposure for 60 and 90 days. Reactive oxygen and nitrogen species (RONS), oxidative stress and inflammatory biomarkers, namely: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), TNF‐α, IL‐1β, xanthine oxidase (XO), nitric oxide (NO) activity were evaluated. Besides, histopathological examination of the lungs and trachea of exposed rats, PPF exposure resulted in significant (P < .05) increases in RONS, biomarkers of oxidative stress, pro‐inflammation cytokines, and reduced (P < .05) GSH levels in rats, secondary to histopathological alteration in lungs and trachea cytoarchitecture examined in an exposure‐duration‐dependent manner. We conclude, therefore, that the observed biochemical and histological changes create a microenvironment that is permissive to diseases pathogenesis of the respiratory system via oxido‐inflammatory mechanistic pathways.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/tox.23019</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4973-0376</orcidid></addata></record> |
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| subjects | Air pollution Biological stress Biomarkers Cytokines Exposure Fumes Gasoline Glutathione Glutathione peroxidase Histopathology Inflammation Inhalation Kerosene Lungs Nitric oxide occupational exposure Organic constituents Oxidative stress oxido‐inflammatory responses Pathogenesis Peroxidase Petroleum petroleum product fumes Petroleum products Reactive nitrogen species Reactive oxygen species Respiration Respiratory system respiratory toxicity RONS Service stations Superoxide dismutase Toxic diseases Toxicity Trachea Tumor necrosis factor Xanthine oxidase |
| title | Oxido‐inflammatory responses and histological alterations in rat lungs exposed to petroleum product fumes |
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