Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol

The Lung Cancer Master Protocol (Lung-MAP; S1400) is a completed biomarker-driven master protocol designed to address an unmet need for better therapies for squamous non-small-cell lung cancer. Lung-MAP (S1400) was created to establish an infrastructure for biomarker screening and rapid regulatory i...

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Veröffentlicht in:	The lancet oncology 2020-12, Vol.21 (12), p.1589-1601
Hauptverfasser:	Redman, Mary W, Papadimitrakopoulou, Vassiliki A, Minichiello, Katherine, Hirsch, Fred R, Mack, Philip C, Schwartz, Lawrence H, Vokes, Everett, Ramalingam, Suresh, Leighl, Natasha, Bradley, Jeff, Miao, Jieling, Moon, James, Highleyman, Louise, Miwa, Crystal, LeBlanc, Michael L, Malik, Shakun, Miller, Vincent A, Sigal, Ellen V, Adam, Stacey, Wholley, David, Sigman, Caroline, Smolich, Beverly, Blanke, Charles D, Kelly, Karen, Gandara, David R, Herbst, Roy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - genetics Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cell cycle Chemotherapy Clinical Decision-Making Clinical trials Disease Progression FDA approval Female Fibroblast growth factor receptors Genomes High-Throughput Nucleotide Sequencing Homologous recombination Homologous recombination repair Humans Immunotherapy Infrastructure Lung cancer Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical research Middle Aged Molecular Targeted Therapy Monoclonal antibodies Mutation Neoplasm Recurrence, Local Neoplasm Staging Next-generation sequencing Non-small cell lung carcinoma Oncology Participation Patients PD-1 protein PD-L1 protein Platinum Precision Medicine Predictive Value of Tests Progression-Free Survival Regulatory approval Targeted cancer therapy Time Factors Young Adult
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