The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes
Interleukin-6 (IL-6) is a pleiotropic cytokine which signals through a cell surface receptor complex consisting of a cognatereceptor subunit (IL-6R) and glycoprotein 130 (gp130), which is considered an antagonist to the IL-6R/IL-6 pathway. The aim of the present study was to assess IL-6/IL-6R/gp130...
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| Veröffentlicht in: | Endokrynologia Polska 2014, Vol.65 (3), p.169-175 |
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| creator | Kuźmicki, Mariusz Telejko, Beata Lipińska, Danuta Pliszka, Justyna Wilk, Juliusz Wawrusiewicz-Kurylonek, Natalia Zielińska, Anna Sobota, Angelika Krętowski, Adam Górska, Maria Szamatowicz, Jacek |
| description | Interleukin-6 (IL-6) is a pleiotropic cytokine which signals through a cell surface receptor complex consisting of a cognatereceptor subunit (IL-6R) and glycoprotein 130 (gp130), which is considered an antagonist to the IL-6R/IL-6 pathway. The aim of the present study was to assess IL-6/IL-6R/gp130 system and Th17 associated cytokines in different time points during and after pregnancy in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
Serum levels of IL-6, sIL6R, sgp130, IL-17 and IL-23 were measured in 91 women divided into three groups: GDMin the 24th-28th week of gestation (visit 1), NGT at the 1st visit and GDM in the 29th-32nd week, and NGT at both visits.
The patients with GDM recognised at the 1st visit had significantly higher IL-6 (p = 0.02) and sgp130 (p = 0.03) concentrations than had the women with NGT, whereas the women with GDM diagnosed at the 2nd visit had elevated sIL-6R concentrations (p = 0.03). The patients with low sIL-6R but high sgp130 concentration had significantly higher glucose levels (p = 0.04) and lower IL-6 values (p = 0.04) than had the patients with low sIL-6R and sgp130 concentrations. IL-17 and IL-23 were detected in approximately one-third of the population studied. A trend towards higher IL-17 levels was observed in the subjects with GDM, but the differences were not significant.
Our results suggest that an increased serum sgp130 concentration in the patients with GDM might represent a compensatory mechanism, controlling intracellular IL-6 signalling and preventing the activation of the IL-6/IL-6R pathway. |
| doi_str_mv | 10.5603/EP.2014.0023 |
| format | Article |
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Serum levels of IL-6, sIL6R, sgp130, IL-17 and IL-23 were measured in 91 women divided into three groups: GDMin the 24th-28th week of gestation (visit 1), NGT at the 1st visit and GDM in the 29th-32nd week, and NGT at both visits.
The patients with GDM recognised at the 1st visit had significantly higher IL-6 (p = 0.02) and sgp130 (p = 0.03) concentrations than had the women with NGT, whereas the women with GDM diagnosed at the 2nd visit had elevated sIL-6R concentrations (p = 0.03). The patients with low sIL-6R but high sgp130 concentration had significantly higher glucose levels (p = 0.04) and lower IL-6 values (p = 0.04) than had the patients with low sIL-6R and sgp130 concentrations. IL-17 and IL-23 were detected in approximately one-third of the population studied. A trend towards higher IL-17 levels was observed in the subjects with GDM, but the differences were not significant.
Our results suggest that an increased serum sgp130 concentration in the patients with GDM might represent a compensatory mechanism, controlling intracellular IL-6 signalling and preventing the activation of the IL-6/IL-6R pathway.</description><identifier>ISSN: 0423-104X</identifier><identifier>EISSN: 2299-8306</identifier><identifier>DOI: 10.5603/EP.2014.0023</identifier><identifier>PMID: 24971916</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adult ; Cytokine Receptor gp130 - blood ; Cytokines ; Diabetes, Gestational - blood ; Diabetes, Gestational - immunology ; Enzyme-Linked Immunosorbent Assay ; Female ; Gestational diabetes ; Humans ; Interleukin-17 - blood ; Interleukin-6 - blood ; Pregnancy ; Risk Factors ; Th17 Cells - metabolism ; Young Adult</subject><ispartof>Endokrynologia Polska, 2014, Vol.65 (3), p.169-175</ispartof><rights>2014. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24971916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuźmicki, Mariusz</creatorcontrib><creatorcontrib>Telejko, Beata</creatorcontrib><creatorcontrib>Lipińska, Danuta</creatorcontrib><creatorcontrib>Pliszka, Justyna</creatorcontrib><creatorcontrib>Wilk, Juliusz</creatorcontrib><creatorcontrib>Wawrusiewicz-Kurylonek, Natalia</creatorcontrib><creatorcontrib>Zielińska, Anna</creatorcontrib><creatorcontrib>Sobota, Angelika</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Górska, Maria</creatorcontrib><creatorcontrib>Szamatowicz, Jacek</creatorcontrib><title>The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes</title><title>Endokrynologia Polska</title><addtitle>Endokrynol Pol</addtitle><description>Interleukin-6 (IL-6) is a pleiotropic cytokine which signals through a cell surface receptor complex consisting of a cognatereceptor subunit (IL-6R) and glycoprotein 130 (gp130), which is considered an antagonist to the IL-6R/IL-6 pathway. The aim of the present study was to assess IL-6/IL-6R/gp130 system and Th17 associated cytokines in different time points during and after pregnancy in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
Serum levels of IL-6, sIL6R, sgp130, IL-17 and IL-23 were measured in 91 women divided into three groups: GDMin the 24th-28th week of gestation (visit 1), NGT at the 1st visit and GDM in the 29th-32nd week, and NGT at both visits.
The patients with GDM recognised at the 1st visit had significantly higher IL-6 (p = 0.02) and sgp130 (p = 0.03) concentrations than had the women with NGT, whereas the women with GDM diagnosed at the 2nd visit had elevated sIL-6R concentrations (p = 0.03). The patients with low sIL-6R but high sgp130 concentration had significantly higher glucose levels (p = 0.04) and lower IL-6 values (p = 0.04) than had the patients with low sIL-6R and sgp130 concentrations. IL-17 and IL-23 were detected in approximately one-third of the population studied. A trend towards higher IL-17 levels was observed in the subjects with GDM, but the differences were not significant.
Our results suggest that an increased serum sgp130 concentration in the patients with GDM might represent a compensatory mechanism, controlling intracellular IL-6 signalling and preventing the activation of the IL-6/IL-6R pathway.</description><subject>Adult</subject><subject>Cytokine Receptor gp130 - blood</subject><subject>Cytokines</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gestational diabetes</subject><subject>Humans</subject><subject>Interleukin-17 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Th17 Cells - metabolism</subject><subject>Young Adult</subject><issn>0423-104X</issn><issn>2299-8306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNo1kMFLwzAYxYMobszdPEvAc7fkS5o0RxlTBwNFJnirSft1i25tbVJk_70V5-U9ePx4PB4h15zNUsXEfPk8A8bljDEQZ2QMYEySCabOyZhJEAln8m1EpiF4NxBKskyoSzICaTQ3XI3J-2aHdLVO1PxXXuZh23LBaDiGiAdq65JudlxTG0JTeBuxpMUxNp--xkB9TVsbPdYx0G8fd3SLIQ5BU9s9Lb11GDFckYvK7gNOTz4hr_fLzeIxWT89rBZ366QFYWJiKyyEk0xA6hAlUxVkmVQGodCFTEsOqZAZh6wyqtDSoWG6cpkeUDCgUjEht3-9bdd89cOQ_KPpu2FJyEEqCUxLLgbq5kT17oBl3nb-YLtj_n-I-AGvw2AA</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kuźmicki, Mariusz</creator><creator>Telejko, Beata</creator><creator>Lipińska, Danuta</creator><creator>Pliszka, Justyna</creator><creator>Wilk, Juliusz</creator><creator>Wawrusiewicz-Kurylonek, Natalia</creator><creator>Zielińska, Anna</creator><creator>Sobota, Angelika</creator><creator>Krętowski, Adam</creator><creator>Górska, Maria</creator><creator>Szamatowicz, Jacek</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2014</creationdate><title>The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes</title><author>Kuźmicki, Mariusz ; Telejko, Beata ; Lipińska, Danuta ; Pliszka, Justyna ; Wilk, Juliusz ; Wawrusiewicz-Kurylonek, Natalia ; Zielińska, Anna ; Sobota, Angelika ; Krętowski, Adam ; Górska, Maria ; Szamatowicz, Jacek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-afec3b40325bee406f288469e2c7c45d125348128f96c74be907fb87e40292653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Cytokine Receptor gp130 - blood</topic><topic>Cytokines</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gestational diabetes</topic><topic>Humans</topic><topic>Interleukin-17 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Th17 Cells - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuźmicki, Mariusz</creatorcontrib><creatorcontrib>Telejko, Beata</creatorcontrib><creatorcontrib>Lipińska, Danuta</creatorcontrib><creatorcontrib>Pliszka, Justyna</creatorcontrib><creatorcontrib>Wilk, Juliusz</creatorcontrib><creatorcontrib>Wawrusiewicz-Kurylonek, Natalia</creatorcontrib><creatorcontrib>Zielińska, Anna</creatorcontrib><creatorcontrib>Sobota, Angelika</creatorcontrib><creatorcontrib>Krętowski, Adam</creatorcontrib><creatorcontrib>Górska, Maria</creatorcontrib><creatorcontrib>Szamatowicz, Jacek</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Endokrynologia Polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuźmicki, Mariusz</au><au>Telejko, Beata</au><au>Lipińska, Danuta</au><au>Pliszka, Justyna</au><au>Wilk, Juliusz</au><au>Wawrusiewicz-Kurylonek, Natalia</au><au>Zielińska, Anna</au><au>Sobota, Angelika</au><au>Krętowski, Adam</au><au>Górska, Maria</au><au>Szamatowicz, Jacek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes</atitle><jtitle>Endokrynologia Polska</jtitle><addtitle>Endokrynol Pol</addtitle><date>2014</date><risdate>2014</risdate><volume>65</volume><issue>3</issue><spage>169</spage><epage>175</epage><pages>169-175</pages><issn>0423-104X</issn><eissn>2299-8306</eissn><abstract>Interleukin-6 (IL-6) is a pleiotropic cytokine which signals through a cell surface receptor complex consisting of a cognatereceptor subunit (IL-6R) and glycoprotein 130 (gp130), which is considered an antagonist to the IL-6R/IL-6 pathway. The aim of the present study was to assess IL-6/IL-6R/gp130 system and Th17 associated cytokines in different time points during and after pregnancy in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT).
Serum levels of IL-6, sIL6R, sgp130, IL-17 and IL-23 were measured in 91 women divided into three groups: GDMin the 24th-28th week of gestation (visit 1), NGT at the 1st visit and GDM in the 29th-32nd week, and NGT at both visits.
The patients with GDM recognised at the 1st visit had significantly higher IL-6 (p = 0.02) and sgp130 (p = 0.03) concentrations than had the women with NGT, whereas the women with GDM diagnosed at the 2nd visit had elevated sIL-6R concentrations (p = 0.03). The patients with low sIL-6R but high sgp130 concentration had significantly higher glucose levels (p = 0.04) and lower IL-6 values (p = 0.04) than had the patients with low sIL-6R and sgp130 concentrations. IL-17 and IL-23 were detected in approximately one-third of the population studied. A trend towards higher IL-17 levels was observed in the subjects with GDM, but the differences were not significant.
Our results suggest that an increased serum sgp130 concentration in the patients with GDM might represent a compensatory mechanism, controlling intracellular IL-6 signalling and preventing the activation of the IL-6/IL-6R pathway.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>24971916</pmid><doi>10.5603/EP.2014.0023</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Cytokine Receptor gp130 - blood Cytokines Diabetes, Gestational - blood Diabetes, Gestational - immunology Enzyme-Linked Immunosorbent Assay Female Gestational diabetes Humans Interleukin-17 - blood Interleukin-6 - blood Pregnancy Risk Factors Th17 Cells - metabolism Young Adult |
| title | The IL-6/IL-6R/sgp130 system and Th17 associated cytokines in patients with gestational diabetes |
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