Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia
Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia. We ordered following tests for...
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| Veröffentlicht in: | Endokrynologia Polska 2012, Vol.63 (4), p.260-263 |
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| creator | Kurtoglu, Aysegul Ugur Kurtoglu, Erdal Temizkan, A Kamil |
| description | Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia.
We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future. |
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We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.</description><identifier>ISSN: 0423-104X</identifier><identifier>EISSN: 2299-8306</identifier><identifier>PMID: 22933160</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adolescent ; Adult ; beta-Thalassemia - complications ; beta-Thalassemia - metabolism ; Blood diseases ; Child ; Diabetes ; Endocrine System Diseases - blood ; Endocrine System Diseases - etiology ; Female ; Ferritins - blood ; Glucose ; Glucose Intolerance - blood ; Glucose Tolerance Test ; Humans ; Hypoparathyroidism - etiology ; Hypothyroidism - etiology ; Iron - blood ; Iron Overload - complications ; Iron Overload - metabolism ; Male ; Middle Aged ; Risk Factors ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood ; Young Adult</subject><ispartof>Endokrynologia Polska, 2012, Vol.63 (4), p.260-263</ispartof><rights>2012. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22933160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurtoglu, Aysegul Ugur</creatorcontrib><creatorcontrib>Kurtoglu, Erdal</creatorcontrib><creatorcontrib>Temizkan, A Kamil</creatorcontrib><title>Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia</title><title>Endokrynologia Polska</title><addtitle>Endokrynol Pol</addtitle><description>Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia.
We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.</description><subject>Adolescent</subject><subject>Adult</subject><subject>beta-Thalassemia - complications</subject><subject>beta-Thalassemia - metabolism</subject><subject>Blood diseases</subject><subject>Child</subject><subject>Diabetes</subject><subject>Endocrine System Diseases - blood</subject><subject>Endocrine System Diseases - etiology</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Glucose</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hypoparathyroidism - etiology</subject><subject>Hypothyroidism - etiology</subject><subject>Iron - blood</subject><subject>Iron Overload - complications</subject><subject>Iron Overload - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><subject>Young Adult</subject><issn>0423-104X</issn><issn>2299-8306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo1kMtKAzEUhoMottS-ggRcD-RmZmYppV6g4EbB3XAyOaEpnWRMUsW3N2Bd_d_i41z-C7IUou-bTjJ9SZZMCdlwpj4WZJ2zN0xIrVgn9TVZVE9KrtmSjFvncCw0OupTDDR-YTpGsLQyBhvH5EOcoew9ZuoDregxlEy_fdlTgwWasocj5Aw4eaATHGKiEGyVC6YJrYcbcuXgmHF9zhV5f9y-bZ6b3evTy-Zh18xC9qUZO2F7PaqxtVor1QJvXW-N5hxA6N5wC9ICIHIJoDh2Tpj6JHTIrbmXTq7I3d_cOcXPE-YyHOIphbpyEEorwXTX9tW6PVsnU88b5uQnSD_DfyfyF5XMYPg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Kurtoglu, Aysegul Ugur</creator><creator>Kurtoglu, Erdal</creator><creator>Temizkan, A Kamil</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>2012</creationdate><title>Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia</title><author>Kurtoglu, Aysegul Ugur ; Kurtoglu, Erdal ; Temizkan, A Kamil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-c82d96c4c7d66447a17f9db611aa269b1da3daaee13aa41e8f2b042a8e1db53f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>beta-Thalassemia - complications</topic><topic>beta-Thalassemia - metabolism</topic><topic>Blood diseases</topic><topic>Child</topic><topic>Diabetes</topic><topic>Endocrine System Diseases - blood</topic><topic>Endocrine System Diseases - etiology</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Glucose</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hypoparathyroidism - etiology</topic><topic>Hypothyroidism - etiology</topic><topic>Iron - blood</topic><topic>Iron Overload - complications</topic><topic>Iron Overload - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurtoglu, Aysegul Ugur</creatorcontrib><creatorcontrib>Kurtoglu, Erdal</creatorcontrib><creatorcontrib>Temizkan, A Kamil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Endokrynologia Polska</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurtoglu, Aysegul Ugur</au><au>Kurtoglu, Erdal</au><au>Temizkan, A Kamil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia</atitle><jtitle>Endokrynologia Polska</jtitle><addtitle>Endokrynol Pol</addtitle><date>2012</date><risdate>2012</risdate><volume>63</volume><issue>4</issue><spage>260</spage><epage>263</epage><pages>260-263</pages><issn>0423-104X</issn><eissn>2299-8306</eissn><abstract>Iron overload is a major problem in patients with b-thalassemia major, and it has many structural and metabolic consequences. In this study, we aimed to consider the prevalence of endocrine abnormalities in patients with β-thalassemia major and thalassemia intermedia.
We ordered following tests for consideration endocrine abnormalities: fasting plasma glucose, oral glucose tolerance, iron, total iron binding capacity, ferritin, thyroid-stimulating hormone (TSH), free thyroxin (fT4), free triiodothyronine (fT3), parathyroid hormone levels.
According to our study including 70 patients with thalassemia major, 7 (10%) had diabetes, 5 (7.1%) had impaired glucose tolerance, 9 (12.8%) had hypothyroidism, 2 (2.8%) had hypoparathyroidism, 2 (2.8%) had hyperparathyroidism. Of 22 patients with thalassemia intermedia, 1 (4.5%) had diabetes.
These findings reinforce the importance of regular follow-up of patients with b-thalassemia major and thalassemia intermedia for early detection and management of associated complications. In this way, the prevalence of endocrine abnormalities can be decreased in future.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>22933160</pmid><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult beta-Thalassemia - complications beta-Thalassemia - metabolism Blood diseases Child Diabetes Endocrine System Diseases - blood Endocrine System Diseases - etiology Female Ferritins - blood Glucose Glucose Intolerance - blood Glucose Tolerance Test Humans Hypoparathyroidism - etiology Hypothyroidism - etiology Iron - blood Iron Overload - complications Iron Overload - metabolism Male Middle Aged Risk Factors Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood Young Adult |
| title | Effect of iron overload on endocrinopathies in patients with beta-thalassaemia major and intermedia |
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