Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities
Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses t...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie International Edition 2020-12, Vol.59 (49), p.21814-21828 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 21828 |
|---|---|
| container_issue | 49 |
| container_start_page | 21814 |
| container_title | Angewandte Chemie International Edition |
| container_volume | 59 |
| creator | Pu, Lin |
| description | Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses them to illustrate the design strategies, applications, and limitations in this area. These probes are potentially useful for rapid analysis of asymmetric reactions for amino acid synthesis as well as the real‐time imaging of amino acids in biological systems. The challenges in these applications are analyzed. Working in this field of enantioselective fluorescent recognition of amino acids offers great opportunities to make new scientific discoveries and to develop important practical applications.
Enantioselective fluorescent probes based on cyclodextrins, 1,1′‐binaphthyl‐based aldehydes, or nanomaterials for free amino acids are used to illustrate the design strategies, applications, and limitations in this area. The challenges and opportunities for using these probes for rapid analysis in the asymmetric synthesis of amino acids as well as enantioselective fluorescent imaging of amino acids in biological systems are discussed. |
| doi_str_mv | 10.1002/anie.202003969 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2463663709</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2463663709</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4769-9a321a085bf9a0091b5a008cf52909912a5b133721d8b63b12cb8b3c7b4150af3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoVqtXjxLwvDUf-xVvpbRaKBZEL16WJDtbU7bJmuwq_fduaa1HTzMwz_sOPAjdUDKihLB7aQ2MGGGEcJGKE3RBE0YjnmX8tN9jzqMsT-gAXYaw7vk8J-k5GnCWEsZifoHep1ba1rgANejWfAGe1Z3zEDTYFr-Aditr-rvFrsIzD4DHG2MdHmtThgc8-ZB1DXYFAUtb4mXTON92uwSEK3RWyTrA9WEO0dts-jp5ihbLx_lkvIh0nKUiEpIzKkmeqEpIQgRVST9yXSVMECEok4minGeMlrlKuaJMq1xxnamYJkRWfIju9r2Nd58dhLZYu87b_mXB4pSnKc-I6KnRntLeheChKhpvNtJvC0qKncpip7I4quwDt4faTm2gPOK_7npA7IFvU8P2n7pi_Dyf_pX_AETJf5A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2463663709</pqid></control><display><type>article</type><title>Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Pu, Lin</creator><creatorcontrib>Pu, Lin</creatorcontrib><description>Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses them to illustrate the design strategies, applications, and limitations in this area. These probes are potentially useful for rapid analysis of asymmetric reactions for amino acid synthesis as well as the real‐time imaging of amino acids in biological systems. The challenges in these applications are analyzed. Working in this field of enantioselective fluorescent recognition of amino acids offers great opportunities to make new scientific discoveries and to develop important practical applications.
Enantioselective fluorescent probes based on cyclodextrins, 1,1′‐binaphthyl‐based aldehydes, or nanomaterials for free amino acids are used to illustrate the design strategies, applications, and limitations in this area. The challenges and opportunities for using these probes for rapid analysis in the asymmetric synthesis of amino acids as well as enantioselective fluorescent imaging of amino acids in biological systems are discussed.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.202003969</identifier><identifier>PMID: 32602243</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Amino acids ; Amino Acids - analysis ; Aqueous solutions ; Chemical synthesis ; chiral recognition ; Cyclodextrin ; Cyclodextrins ; Cyclodextrins - chemical synthesis ; Cyclodextrins - chemistry ; Enantiomers ; enantioselectivity ; fluorescence ; Fluorescent Dyes - chemical synthesis ; Fluorescent Dyes - chemistry ; Fluorescent indicators ; Molecular Structure ; Nanomaterials ; Nanostructures - chemistry ; Nanotechnology ; Naphthalenes - chemical synthesis ; Naphthalenes - chemistry ; Probes ; Recognition ; Stereoisomerism</subject><ispartof>Angewandte Chemie International Edition, 2020-12, Vol.59 (49), p.21814-21828</ispartof><rights>2020 Wiley‐VCH GmbH</rights><rights>2020 Wiley-VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4769-9a321a085bf9a0091b5a008cf52909912a5b133721d8b63b12cb8b3c7b4150af3</citedby><cites>FETCH-LOGICAL-c4769-9a321a085bf9a0091b5a008cf52909912a5b133721d8b63b12cb8b3c7b4150af3</cites><orcidid>0000-0001-8698-3228</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.202003969$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.202003969$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32602243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pu, Lin</creatorcontrib><title>Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses them to illustrate the design strategies, applications, and limitations in this area. These probes are potentially useful for rapid analysis of asymmetric reactions for amino acid synthesis as well as the real‐time imaging of amino acids in biological systems. The challenges in these applications are analyzed. Working in this field of enantioselective fluorescent recognition of amino acids offers great opportunities to make new scientific discoveries and to develop important practical applications.
Enantioselective fluorescent probes based on cyclodextrins, 1,1′‐binaphthyl‐based aldehydes, or nanomaterials for free amino acids are used to illustrate the design strategies, applications, and limitations in this area. The challenges and opportunities for using these probes for rapid analysis in the asymmetric synthesis of amino acids as well as enantioselective fluorescent imaging of amino acids in biological systems are discussed.</description><subject>Amino acids</subject><subject>Amino Acids - analysis</subject><subject>Aqueous solutions</subject><subject>Chemical synthesis</subject><subject>chiral recognition</subject><subject>Cyclodextrin</subject><subject>Cyclodextrins</subject><subject>Cyclodextrins - chemical synthesis</subject><subject>Cyclodextrins - chemistry</subject><subject>Enantiomers</subject><subject>enantioselectivity</subject><subject>fluorescence</subject><subject>Fluorescent Dyes - chemical synthesis</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Fluorescent indicators</subject><subject>Molecular Structure</subject><subject>Nanomaterials</subject><subject>Nanostructures - chemistry</subject><subject>Nanotechnology</subject><subject>Naphthalenes - chemical synthesis</subject><subject>Naphthalenes - chemistry</subject><subject>Probes</subject><subject>Recognition</subject><subject>Stereoisomerism</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoVqtXjxLwvDUf-xVvpbRaKBZEL16WJDtbU7bJmuwq_fduaa1HTzMwz_sOPAjdUDKihLB7aQ2MGGGEcJGKE3RBE0YjnmX8tN9jzqMsT-gAXYaw7vk8J-k5GnCWEsZifoHep1ba1rgANejWfAGe1Z3zEDTYFr-Aditr-rvFrsIzD4DHG2MdHmtThgc8-ZB1DXYFAUtb4mXTON92uwSEK3RWyTrA9WEO0dts-jp5ihbLx_lkvIh0nKUiEpIzKkmeqEpIQgRVST9yXSVMECEok4minGeMlrlKuaJMq1xxnamYJkRWfIju9r2Nd58dhLZYu87b_mXB4pSnKc-I6KnRntLeheChKhpvNtJvC0qKncpip7I4quwDt4faTm2gPOK_7npA7IFvU8P2n7pi_Dyf_pX_AETJf5A</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Pu, Lin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-8698-3228</orcidid></search><sort><creationdate>20201201</creationdate><title>Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities</title><author>Pu, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4769-9a321a085bf9a0091b5a008cf52909912a5b133721d8b63b12cb8b3c7b4150af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Amino Acids - analysis</topic><topic>Aqueous solutions</topic><topic>Chemical synthesis</topic><topic>chiral recognition</topic><topic>Cyclodextrin</topic><topic>Cyclodextrins</topic><topic>Cyclodextrins - chemical synthesis</topic><topic>Cyclodextrins - chemistry</topic><topic>Enantiomers</topic><topic>enantioselectivity</topic><topic>fluorescence</topic><topic>Fluorescent Dyes - chemical synthesis</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Fluorescent indicators</topic><topic>Molecular Structure</topic><topic>Nanomaterials</topic><topic>Nanostructures - chemistry</topic><topic>Nanotechnology</topic><topic>Naphthalenes - chemical synthesis</topic><topic>Naphthalenes - chemistry</topic><topic>Probes</topic><topic>Recognition</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pu, Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pu, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>59</volume><issue>49</issue><spage>21814</spage><epage>21828</epage><pages>21814-21828</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Fluorescent probes that can discriminate enantiomers of amino acids in organic media or aqueous solution are discussed. This Minireview focuses on recent progress in the studies of three classes of probes including those made of cyclodextrins, 1,1′‐binaphthyl compounds, and nanomaterials, and uses them to illustrate the design strategies, applications, and limitations in this area. These probes are potentially useful for rapid analysis of asymmetric reactions for amino acid synthesis as well as the real‐time imaging of amino acids in biological systems. The challenges in these applications are analyzed. Working in this field of enantioselective fluorescent recognition of amino acids offers great opportunities to make new scientific discoveries and to develop important practical applications.
Enantioselective fluorescent probes based on cyclodextrins, 1,1′‐binaphthyl‐based aldehydes, or nanomaterials for free amino acids are used to illustrate the design strategies, applications, and limitations in this area. The challenges and opportunities for using these probes for rapid analysis in the asymmetric synthesis of amino acids as well as enantioselective fluorescent imaging of amino acids in biological systems are discussed.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32602243</pmid><doi>10.1002/anie.202003969</doi><tpages>15</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0001-8698-3228</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2020-12, Vol.59 (49), p.21814-21828 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_journals_2463663709 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Amino acids Amino Acids - analysis Aqueous solutions Chemical synthesis chiral recognition Cyclodextrin Cyclodextrins Cyclodextrins - chemical synthesis Cyclodextrins - chemistry Enantiomers enantioselectivity fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators Molecular Structure Nanomaterials Nanostructures - chemistry Nanotechnology Naphthalenes - chemical synthesis Naphthalenes - chemistry Probes Recognition Stereoisomerism |
| title | Enantioselective Fluorescent Recognition of Free Amino Acids: Challenges and Opportunities |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T13%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enantioselective%20Fluorescent%20Recognition%20of%20Free%20Amino%20Acids:%20Challenges%20and%20Opportunities&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Pu,%20Lin&rft.date=2020-12-01&rft.volume=59&rft.issue=49&rft.spage=21814&rft.epage=21828&rft.pages=21814-21828&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.202003969&rft_dat=%3Cproquest_cross%3E2463663709%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2463663709&rft_id=info:pmid/32602243&rfr_iscdi=true |