1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2020-01, Vol.35 (1), p.993-1002
Hauptverfasser:	Kaproń, Barbara, Czarnomysy, Robert, Wysokiński, Mariusz, Andrys, Rudolf, Musilek, Kamil, Angeli, Andrea, Supuran, Claudiu T., Plech, Tomasz
Format:	Artikel
Sprache:	eng
Schlagworte:	6 Hz psychomotor seizures Acetylcholinesterase Acetylcholinesterase - metabolism Animals Anticonvulsants Anticonvulsants - chemical synthesis Anticonvulsants - chemistry Anticonvulsants - pharmacology Antiepileptic agents Antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology ATP-binding protein Biphenyl Compounds - antagonists & inhibitors Butyrylcholinesterase - metabolism Carbonic Anhydrase Inhibitors - chemical synthesis Carbonic Anhydrase Inhibitors - chemistry Carbonic Anhydrase Inhibitors - pharmacology Carbonic anhydrases Carbonic Anhydrases - metabolism Cell Line, Tumor Cell Survival - drug effects cholinesterase inhibitors Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cognitive ability Dose-Response Relationship, Drug Drug development Drug resistance Electron transfer Epilepsy Epilepsy - drug therapy Epilepsy - metabolism Flow cytometry Humans Mice mitochondrial potential Models, Molecular Molecular Structure Oxidative stress Oxidative Stress - drug effects Picrates - antagonists & inhibitors Reactive Oxygen Species - metabolism Research Paper Structure-Activity Relationship total ROS activity Triazoles - chemical synthesis Triazoles - chemistry Triazoles - pharmacology Valproic acid
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