APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort
The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospita...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2020-11, Vol.75 (11), p.2231-2232 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Kuo, Chia-Ling Pilling, Luke C Atkins, Janice L Masoli, Jane A H Delgado, João Kuchel, George A Melzer, David |
| description | The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with a 14-fold increase in risk of Alzheimer's disease compared to the common e3e3 genotype, in populations with European ancestries. The need to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data, is also emphasized. |
| doi_str_mv | 10.1093/gerona/glaa131 |
| format | Article |
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In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with a 14-fold increase in risk of Alzheimer's disease compared to the common e3e3 genotype, in populations with European ancestries. The need to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data, is also emphasized.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glaa131</identifier><identifier>PMID: 32451547</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Alzheimer's disease ; Apolipoprotein E4 ; Apolipoprotein E4 - genetics ; Betacoronavirus - physiology ; Biological Specimen Banks ; Comorbidity ; Coronavirus Infections - epidemiology ; Coronavirus Infections - genetics ; Coronavirus Infections - physiopathology ; Coronavirus Infections - virology ; Cough ; COVID-19 ; Delirium ; Dementia ; Dementia disorders ; England - epidemiology ; Female ; Fever ; Genetic Predisposition to Disease ; Genotypes ; Geriatrics & Gerontology ; Gerontology ; Homozygote ; Humans ; Life Sciences & Biomedicine ; Male ; Neurodegenerative diseases ; Older people ; Pandemics ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - genetics ; Pneumonia, Viral - physiopathology ; Pneumonia, Viral - virology ; Polymorphism, Single Nucleotide ; Respiratory diseases ; Risk factors ; SARS-CoV-2 ; Science & Technology ; Severity of Illness Index ; Survival Analysis ; THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><ispartof>The journals of gerontology. 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Series A, Biological sciences and medical sciences</title><addtitle>J GERONTOL A-BIOL</addtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and shortness of breath being common. In older adults, it has been found that preexisting dementia is a major risk factor for COVID-19 severity in the UK Biobank (UKB). In another UK study of 16,749 patients hospitalized for COVID-19, dementia was among the common comorbidities and was associated with higher mortality. Additionally, impaired consciousness, including delirium, is common in severe cases. The ApoE e4 genotype is associated with both dementia and delirium, with the e4e4 (homozygous) genotype associated with a 14-fold increase in risk of Alzheimer's disease compared to the common e3e3 genotype, in populations with European ancestries. The need to test associations between ApoE e4 alleles and COVID-19 severity, using the UKB data, is also emphasized.</description><subject>Aged</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Betacoronavirus - physiology</subject><subject>Biological Specimen Banks</subject><subject>Comorbidity</subject><subject>Coronavirus Infections - epidemiology</subject><subject>Coronavirus Infections - genetics</subject><subject>Coronavirus Infections - physiopathology</subject><subject>Coronavirus Infections - virology</subject><subject>Cough</subject><subject>COVID-19</subject><subject>Delirium</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>England - epidemiology</subject><subject>Female</subject><subject>Fever</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotypes</subject><subject>Geriatrics & Gerontology</subject><subject>Gerontology</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Neurodegenerative diseases</subject><subject>Older people</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - epidemiology</subject><subject>Pneumonia, Viral - genetics</subject><subject>Pneumonia, Viral - physiopathology</subject><subject>Pneumonia, Viral - virology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Respiratory diseases</subject><subject>Risk factors</subject><subject>SARS-CoV-2</subject><subject>Science & Technology</subject><subject>Severity of Illness Index</subject><subject>Survival Analysis</subject><subject>THE JOURNAL OF GERONTOLOGY: Medical Sciences</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhSMEoqVw5YgscQGhtHZsx8kFqYRSKlbaSlDEzXKcya5LYi-2U7T_Hi9ZVsAFfPFI872nN3pZ9pTgU4JrerYC76w6Ww1KEUruZcdE8CrnlH-5n2Ys6pxjXB5lj0K4xbvHi4fZES0YJ5yJ42xxfr28QMDQJVgXtxtA1x46o2NAH-EOPKBm-fnqbU5qZCyKa0A3H9Ab41plv6LGjeNkTdymae18fJw96NUQ4Mn-P8lu3l18at7ni-XlVXO-yDXjRcx1iwvKOkUrouuaAaSYgpGqB85VzwRgVWndkb4UjBLFSMFLoUosRF93rSb0JHs9-26mdoROg41eDXLjzaj8Vjpl5J8ba9Zy5e6koIQRWieDF3sD775NEKIcTdAwDMqCm4IsGC5rXtCSJfT5X-itm7xN5yWqpKQUmBSJOp0p7V0IHvpDGILlrig5FyX3RSXBs99POOC_mknAqxn4Dq3rgzZgNRywXZGirsTPSilOdPX_dGOiisbZxk02JunLWeqmzb9S_wCS0b2M</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Kuo, Chia-Ling</creator><creator>Pilling, Luke C</creator><creator>Atkins, Janice L</creator><creator>Masoli, Jane A H</creator><creator>Delgado, João</creator><creator>Kuchel, George A</creator><creator>Melzer, David</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>TOX</scope><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1648-871X</orcidid><orcidid>https://orcid.org/0000-0002-3332-8454</orcidid><orcidid>https://orcid.org/0000-0003-4919-9068</orcidid><orcidid>https://orcid.org/0000-0003-3794-7065</orcidid><orcidid>https://orcid.org/0000-0003-4452-2380</orcidid><orcidid>https://orcid.org/0000-0001-8387-7040</orcidid></search><sort><creationdate>20201101</creationdate><title>APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort</title><author>Kuo, Chia-Ling ; 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| subjects | Aged Alzheimer's disease Apolipoprotein E4 Apolipoprotein E4 - genetics Betacoronavirus - physiology Biological Specimen Banks Comorbidity Coronavirus Infections - epidemiology Coronavirus Infections - genetics Coronavirus Infections - physiopathology Coronavirus Infections - virology Cough COVID-19 Delirium Dementia Dementia disorders England - epidemiology Female Fever Genetic Predisposition to Disease Genotypes Geriatrics & Gerontology Gerontology Homozygote Humans Life Sciences & Biomedicine Male Neurodegenerative diseases Older people Pandemics Pneumonia, Viral - epidemiology Pneumonia, Viral - genetics Pneumonia, Viral - physiopathology Pneumonia, Viral - virology Polymorphism, Single Nucleotide Respiratory diseases Risk factors SARS-CoV-2 Science & Technology Severity of Illness Index Survival Analysis THE JOURNAL OF GERONTOLOGY: Medical Sciences |
| title | APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort |
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