Scutellaria baicalensis Flavones as Potent Drugs against Acute Respiratory Injury during SARS-CoV-2 Infection: Structural Biology Approaches

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe damage to the respiratory system. With no specific treatment to date, it is crucial to identify potent inhibitors of SARS-CoV-2 Chymotrypsin-like protease (3CLpro) that could also modulate the enzymes involve...

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Veröffentlicht in:	Processes 2020-11, Vol.8 (11), p.1468
Hauptverfasser:	Udrea, Ana-Maria, Mernea, Maria, Buiu, Cătălin, Avram, Speranța
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonate 15-lipoxygenase Baicalin Bioinformatics Cancer therapies Cell cycle Chemical compounds Chymotrypsin Coronaviruses COVID-19 Cyclin-dependent kinases Cytokines Damage Drugs Enzymes Flavones Flavonoids Hydrogen bonds Hypoxia Infections Inflammation Informatics Injuries Kinases Ligands Lipoxygenase Lung cancer Lysine Molecular weight Nitric oxide Nitric-oxide synthase Pharmacodynamics Pharmacokinetics Pharmacology Pneumonia Protease Protease inhibitors Proteinase Proteinase inhibitors Proteins Respiratory diseases Respiratory distress syndrome Respiratory system Scutellaria baicalensis Severe acute respiratory syndrome coronavirus 2 Toxicology Tumor necrosis factor-TNF Viral diseases Viral infections
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