DNA binding, cleavage, apoptosis and cytotoxicity studies of three heteroleptic nickel complexes bearing β-diketones

[Display omitted] •NiII complexes are capable of binding in the minor groove of DNA.•DNA cleavage was observed.•Two NiII complexes were more active than cisplatin toward cancer cell lines.•Two NiII complexes induced late apoptosis. In this work, three nickel(II) complexes, namely, [Ni(η2-NO3)(bta)(p...

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Veröffentlicht in:	Inorganica Chimica Acta 2020-10, Vol.511, p.119824, Article 119824
Hauptverfasser:	Sousa, Luana M., Souza, Wesley A., Paixão, Drielly A., Fazzi, Rodrigo B., Tezuka, Daiane Y., Lopes, Carla D., Carneiro, Zumira A., Moreira, Mariete B., Pivatto, Marcos, Netto, Adelino V.G., de Albuquerque, Sérgio, Ferreira, Francis B., De Oliveira, Ronaldo J., Resende, Jackson A.L.C., Lino, Ricardo C., De Oliveira Júnior, Robson J., Da Costa Ferreira, Ana M., Guerra, Wendell
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions Anticancer properties Apoptosis Binding Cancer Chelation Cleavage Coordination compounds Crystal structure Deoxyribonucleic acid Dichroism Diketones DNA DNA binding DNA cleavage Fluorescence Grooves Hydrogen peroxide Magnetic permeability Molecular docking Nickel Nickel complexes Nitrogen atoms Oxygen atoms Plasmids Single crystals Toxicity β-diketones
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