Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

Summary Background Potassium‐competitive acid blockers (P‐CABs) are emerging as novel treatments for acid‐related disorders including gastroesophageal reflux disease. Tegoprazan and revaprazan are approved P‐CABs in South Korea, but the pharmacodynamics and safety/tolerability of the two drugs have...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2020-12, Vol.52 (11-12), p.1640-1647
Hauptverfasser:	Sunwoo, Jung, Ji, Sang Chun, Oh, Jaeseong, Ban, Mu Seong, Nam, Ji Yeon, Kim, Bongtae, Song, Geun Seog, Yu, Kyung‐Sang, Jang, In‐Jin, Lee, SeungHwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Benzene Derivatives - administration & dosage Dose-Response Relationship, Drug Drug dosages Gastric juice Gastrin Gastroesophageal reflux Gastroesophageal Reflux - drug therapy Humans Imidazoles - administration & dosage Male MicroRNAs - blood miRNA Oral administration pH effects Pharmacodynamics Pyrimidinones - administration & dosage Republic of Korea Safety Stomach - drug effects Tetrahydroisoquinolines - administration & dosage Young Adult
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