Metal‐Free Decarboxylation of Alkynoic Acids for the Synthesis of Terminal Alkynes

Terminal alkynes were readily obtained via the reaction of alkynoic acids with N,N,N’,N’‐teramethylethylenediamine (TMEDA) in DMSO at 65 °C for 12 h. This method gave good yields and showed high functional group tolerance. In addition, deuterated terminal alkynes were formed in good yields when alky...

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Veröffentlicht in:	Asian journal of organic chemistry 2020-11, Vol.9 (11), p.1774-1777
Hauptverfasser:	Seo, Eunkyeong, Oh, Jonghoon, Lee, Sunwoo
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Sprache:	eng
Schlagworte:	Alkynes alkynoic aicd Decarboxylation Deuteration Functional groups metal-free conditions Organic chemistry terminal alkyne
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description	Terminal alkynes were readily obtained via the reaction of alkynoic acids with N,N,N’,N’‐teramethylethylenediamine (TMEDA) in DMSO at 65 °C for 12 h. This method gave good yields and showed high functional group tolerance. In addition, deuterated terminal alkynes were formed in good yields when alkynoic acids were treated with D2O prior to the reaction with TMEDA. In the presence of TMEDA, alkynoic acid derivatives afforded the corresponding terminal alkynes in good yields.
doi_str_mv	10.1002/ajoc.202000363
format	Article
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subjects	Alkynes alkynoic aicd Decarboxylation Deuteration Functional groups metal-free conditions Organic chemistry terminal alkyne
title	Metal‐Free Decarboxylation of Alkynoic Acids for the Synthesis of Terminal Alkynes
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