Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel
Hydrogels are three-dimensional (3D) polymeric networks that have been used in many applications, including drug delivery, wound dressing, and tissue engineering. This study aimed to develop gamma-irradiated poly(ethylene glycol)diacrylate and chitosan (PEGDA-Chi) hydrogel as a 3D scaffold for antib...
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| creator | Masyruroh, Siti Fikroh Lasmawati, Deudeu Suryani, Nani Sumarlin, La Ode Nurlidar, Farah |
| description | Hydrogels are three-dimensional (3D) polymeric networks that have been used in many applications, including drug delivery, wound dressing, and tissue engineering. This study aimed to develop gamma-irradiated poly(ethylene glycol)diacrylate and chitosan (PEGDA-Chi) hydrogel as a 3D scaffold for antibiotic encapsulation. Ciprofloxacin (CPFX) was used as a model antibiotic to study the encapsulation and release properties of the hydrogels containing antibiotic. Gel fraction, absorption capacity, and in vitro antibiotic release analyses are used to characterize the PEGDA- Chi hydrogel containing CPFX. In vitro release experiment in phosphate-buffered saline of the hydrogels containing CPFX showed that 25 kGy of PEGDA-Chi hydrogel released higher CPFX (97.34±0.41%) within 150 minutes than that 25 kGy of PEGDA hydrogel (87.96±0.83%) did. Antibacterial activity of the hydrogels containing CPFX evaluated by disk diffusion method showed that the hydrogels displayed antibacterial activities against Staphylococcus aureus. Taken together, these results suggest that the PEGDA-Chi hydrogel containing ciprofloxacin could be used as an antibacterial 3D scaffolding material. |
| doi_str_mv | 10.1063/5.0030348 |
| format | Conference Proceeding |
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This study aimed to develop gamma-irradiated poly(ethylene glycol)diacrylate and chitosan (PEGDA-Chi) hydrogel as a 3D scaffold for antibiotic encapsulation. Ciprofloxacin (CPFX) was used as a model antibiotic to study the encapsulation and release properties of the hydrogels containing antibiotic. Gel fraction, absorption capacity, and in vitro antibiotic release analyses are used to characterize the PEGDA- Chi hydrogel containing CPFX. In vitro release experiment in phosphate-buffered saline of the hydrogels containing CPFX showed that 25 kGy of PEGDA-Chi hydrogel released higher CPFX (97.34±0.41%) within 150 minutes than that 25 kGy of PEGDA hydrogel (87.96±0.83%) did. Antibacterial activity of the hydrogels containing CPFX evaluated by disk diffusion method showed that the hydrogels displayed antibacterial activities against Staphylococcus aureus. 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Taken together, these results suggest that the PEGDA-Chi hydrogel containing ciprofloxacin could be used as an antibacterial 3D scaffolding material.</description><subject>Antibiotics</subject><subject>Chitosan</subject><subject>Drug delivery systems</subject><subject>Encapsulation</subject><subject>Ethylene glycol</subject><subject>Hydrogels</subject><subject>Scaffolding</subject><subject>Tissue engineering</subject><subject>Wound healing</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2020</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNotkFtLAzEQhYMoWKsP_oMF34TUyWVzeSy1rUJBEQXfQtxk25TdTU22YP-9W9qnwxwOM3M-hO4JTAgI9lROABgwri7QiJQlwVIQcYlGAJpjytn3NbrJeQtAtZRqhBYfvvE2-yLWRRV2KdZN_LNV6Io6xbZY27a1OKRkXbC9d8X7fPk8xdUm9DHbrtgcXIpr39yiq9o22d-ddYy-FvPP2QtevS1fZ9MVrqhmPVbOW2FVST0Q_SOIdUxpqhU4zzTxQlMHg19zXVkOHgCck1IeB-B-6DdGD6e9w6e_e597s4371A0nDeUClFCUyiH1eErlKvS2D7EzuxRamw6GgDlyMqU5c2L_w8xYyg</recordid><startdate>20201116</startdate><enddate>20201116</enddate><creator>Masyruroh, Siti Fikroh</creator><creator>Lasmawati, Deudeu</creator><creator>Suryani, Nani</creator><creator>Sumarlin, La Ode</creator><creator>Nurlidar, Farah</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20201116</creationdate><title>Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel</title><author>Masyruroh, Siti Fikroh ; Lasmawati, Deudeu ; Suryani, Nani ; Sumarlin, La Ode ; Nurlidar, Farah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-8dea6a852e019b61ad3892980de391e692d09b6f49ca40e000dd777ca4004e063</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotics</topic><topic>Chitosan</topic><topic>Drug delivery systems</topic><topic>Encapsulation</topic><topic>Ethylene glycol</topic><topic>Hydrogels</topic><topic>Scaffolding</topic><topic>Tissue engineering</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masyruroh, Siti Fikroh</creatorcontrib><creatorcontrib>Lasmawati, Deudeu</creatorcontrib><creatorcontrib>Suryani, Nani</creatorcontrib><creatorcontrib>Sumarlin, La Ode</creatorcontrib><creatorcontrib>Nurlidar, Farah</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masyruroh, Siti Fikroh</au><au>Lasmawati, Deudeu</au><au>Suryani, Nani</au><au>Sumarlin, La Ode</au><au>Nurlidar, Farah</au><au>Purnama, Budi</au><au>Nugraha, Dewanta Arya</au><au>Anwar, Fuad</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel</atitle><btitle>AIP conference proceedings</btitle><date>2020-11-16</date><risdate>2020</risdate><volume>2296</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>Hydrogels are three-dimensional (3D) polymeric networks that have been used in many applications, including drug delivery, wound dressing, and tissue engineering. This study aimed to develop gamma-irradiated poly(ethylene glycol)diacrylate and chitosan (PEGDA-Chi) hydrogel as a 3D scaffold for antibiotic encapsulation. Ciprofloxacin (CPFX) was used as a model antibiotic to study the encapsulation and release properties of the hydrogels containing antibiotic. Gel fraction, absorption capacity, and in vitro antibiotic release analyses are used to characterize the PEGDA- Chi hydrogel containing CPFX. In vitro release experiment in phosphate-buffered saline of the hydrogels containing CPFX showed that 25 kGy of PEGDA-Chi hydrogel released higher CPFX (97.34±0.41%) within 150 minutes than that 25 kGy of PEGDA hydrogel (87.96±0.83%) did. Antibacterial activity of the hydrogels containing CPFX evaluated by disk diffusion method showed that the hydrogels displayed antibacterial activities against Staphylococcus aureus. 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| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2020, Vol.2296 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_proquest_journals_2460868227 |
| source | AIP Journals Complete |
| subjects | Antibiotics Chitosan Drug delivery systems Encapsulation Ethylene glycol Hydrogels Scaffolding Tissue engineering Wound healing |
| title | Release of ciprofloxacin from gamma-irradiated PEGDA-chitosan hydrogel |
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