Predictive value of CD8/FOXP3 ratio combined with PD‐L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy
Background Little is known about immune‐related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC‐L) treated with radiation therapy (RT). Methods We retrospectively reviewed 91 patients with SCC‐L treated with RT or chemoradiation therapy and performed immunohistochemical...
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| Veröffentlicht in: | Head & neck 2020-12, Vol.42 (12), p.3518-3530 |
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| creator | Ono, Takeharu Azuma, Koichi Kawahara, Akihiko Kakuma, Tatsuyuki Sato, Fumihiko Akiba, Jun Tanaka, Norimitsu Abe, Toshi Chitose, Shun‐ichi Umeno, Hirohito |
| description | Background
Little is known about immune‐related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC‐L) treated with radiation therapy (RT).
Methods
We retrospectively reviewed 91 patients with SCC‐L treated with RT or chemoradiation therapy and performed immunohistochemical examination to analyze PD‐L1 level on tumor cells, CD4+ tumor‐infiltrating lymphocytes (TILs), CD8+TIL, and FOXP3+TIL using pretreated biopsy specimens. The association between these immune‐related parameters and radiosensitivity was evaluated.
Results
Multivariate analyses showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression was an independent and significant favorable predictive factor for local control, compared with the other groups.
Conclusions
We showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression might be a useful biomarker of radiosensitivity in patients with SCC‐L receiving definitive RT. We propose that coassessment of CD8/FOXP3 ratio and PD‐L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC‐L. |
| doi_str_mv | 10.1002/hed.26416 |
| format | Article |
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Little is known about immune‐related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC‐L) treated with radiation therapy (RT).
Methods
We retrospectively reviewed 91 patients with SCC‐L treated with RT or chemoradiation therapy and performed immunohistochemical examination to analyze PD‐L1 level on tumor cells, CD4+ tumor‐infiltrating lymphocytes (TILs), CD8+TIL, and FOXP3+TIL using pretreated biopsy specimens. The association between these immune‐related parameters and radiosensitivity was evaluated.
Results
Multivariate analyses showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression was an independent and significant favorable predictive factor for local control, compared with the other groups.
Conclusions
We showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression might be a useful biomarker of radiosensitivity in patients with SCC‐L receiving definitive RT. We propose that coassessment of CD8/FOXP3 ratio and PD‐L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC‐L.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26416</identifier><identifier>PMID: 32808399</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>B7-H1 Antigen ; Biopsy ; CD4 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes ; CD8/FOXP3 ratio ; Chemoradiotherapy ; Forkhead Transcription Factors - genetics ; Foxp3 protein ; Head and neck ; Head and Neck Neoplasms ; Humans ; Laryngeal cancer ; Larynx ; local control ; Lymphocytes ; PD-L1 protein ; PD‐L1 expression ; Prognosis ; Radiation therapy ; Radiation Tolerance ; Radiosensitivity ; Retrospective Studies ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck ; Tumor cells</subject><ispartof>Head & neck, 2020-12, Vol.42 (12), p.3518-3530</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2686-53f43300e650d5f71cac88841cbb3eb9b16ac1f422f510fb0d6068294ce6cfa23</citedby><cites>FETCH-LOGICAL-c2686-53f43300e650d5f71cac88841cbb3eb9b16ac1f422f510fb0d6068294ce6cfa23</cites><orcidid>0000-0003-2414-7034 ; 0000-0002-9307-2331</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26416$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26416$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32808399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ono, Takeharu</creatorcontrib><creatorcontrib>Azuma, Koichi</creatorcontrib><creatorcontrib>Kawahara, Akihiko</creatorcontrib><creatorcontrib>Kakuma, Tatsuyuki</creatorcontrib><creatorcontrib>Sato, Fumihiko</creatorcontrib><creatorcontrib>Akiba, Jun</creatorcontrib><creatorcontrib>Tanaka, Norimitsu</creatorcontrib><creatorcontrib>Abe, Toshi</creatorcontrib><creatorcontrib>Chitose, Shun‐ichi</creatorcontrib><creatorcontrib>Umeno, Hirohito</creatorcontrib><title>Predictive value of CD8/FOXP3 ratio combined with PD‐L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Little is known about immune‐related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC‐L) treated with radiation therapy (RT).
Methods
We retrospectively reviewed 91 patients with SCC‐L treated with RT or chemoradiation therapy and performed immunohistochemical examination to analyze PD‐L1 level on tumor cells, CD4+ tumor‐infiltrating lymphocytes (TILs), CD8+TIL, and FOXP3+TIL using pretreated biopsy specimens. The association between these immune‐related parameters and radiosensitivity was evaluated.
Results
Multivariate analyses showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression was an independent and significant favorable predictive factor for local control, compared with the other groups.
Conclusions
We showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression might be a useful biomarker of radiosensitivity in patients with SCC‐L receiving definitive RT. We propose that coassessment of CD8/FOXP3 ratio and PD‐L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC‐L.</description><subject>B7-H1 Antigen</subject><subject>Biopsy</subject><subject>CD4 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>CD8/FOXP3 ratio</subject><subject>Chemoradiotherapy</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Foxp3 protein</subject><subject>Head and neck</subject><subject>Head and Neck Neoplasms</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Larynx</subject><subject>local control</subject><subject>Lymphocytes</subject><subject>PD-L1 protein</subject><subject>PD‐L1 expression</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiation Tolerance</subject><subject>Radiosensitivity</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Tumor cells</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQh6MK1Ja2B14AWeLEId3xn_UmR7TbUqSVugeQuEWOM2ZdJXZqJ233xiPwNrwPT4LTtEdOY42--WasX5a9p3BJAdhij80lk4LKo-yUQrnKgYvVm-kteM5hJU6ydzHeAQCXgh1nJ5wVUPCyPM3-7AI2Vg_2AcmDakck3pD1plhc3_7YcRLUYD3Rvqutw4Y82mFPdpu_v35vKcGnPmCM1jtifEhoY31EF22S2eFArCN9Gkc3xHkw3o-q82MkGtuWaBW0db5T08Zhj6RV4eCeSECNSeB-kgaNdfb5tEk-neImMqj-cJ69NaqNePFSz7Lv11ff1jf59vbL1_Xnba6ZLGS-5EZwDoByCc3SrKhWuigKQXVdc6zLmkqlqRGMmSUFU0MjQRasFBqlNorxs-zj7O2Dvx8xDtWdH4NLKysmJNCyoAIS9WmmdPAxBjRVH2yX_lNRqKaIqhRR9RxRYj-8GMe6S91X8jWTBCxm4NG2ePi_qbq52szKf8jZnwM</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Ono, Takeharu</creator><creator>Azuma, Koichi</creator><creator>Kawahara, Akihiko</creator><creator>Kakuma, Tatsuyuki</creator><creator>Sato, Fumihiko</creator><creator>Akiba, Jun</creator><creator>Tanaka, Norimitsu</creator><creator>Abe, Toshi</creator><creator>Chitose, Shun‐ichi</creator><creator>Umeno, Hirohito</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-2414-7034</orcidid><orcidid>https://orcid.org/0000-0002-9307-2331</orcidid></search><sort><creationdate>202012</creationdate><title>Predictive value of CD8/FOXP3 ratio combined with PD‐L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy</title><author>Ono, Takeharu ; Azuma, Koichi ; Kawahara, Akihiko ; Kakuma, Tatsuyuki ; Sato, Fumihiko ; Akiba, Jun ; Tanaka, Norimitsu ; Abe, Toshi ; Chitose, Shun‐ichi ; Umeno, Hirohito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2686-53f43300e650d5f71cac88841cbb3eb9b16ac1f422f510fb0d6068294ce6cfa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>B7-H1 Antigen</topic><topic>Biopsy</topic><topic>CD4 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>CD8/FOXP3 ratio</topic><topic>Chemoradiotherapy</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Foxp3 protein</topic><topic>Head and neck</topic><topic>Head and Neck Neoplasms</topic><topic>Humans</topic><topic>Laryngeal cancer</topic><topic>Larynx</topic><topic>local control</topic><topic>Lymphocytes</topic><topic>PD-L1 protein</topic><topic>PD‐L1 expression</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Radiation Tolerance</topic><topic>Radiosensitivity</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ono, Takeharu</creatorcontrib><creatorcontrib>Azuma, Koichi</creatorcontrib><creatorcontrib>Kawahara, Akihiko</creatorcontrib><creatorcontrib>Kakuma, Tatsuyuki</creatorcontrib><creatorcontrib>Sato, Fumihiko</creatorcontrib><creatorcontrib>Akiba, Jun</creatorcontrib><creatorcontrib>Tanaka, Norimitsu</creatorcontrib><creatorcontrib>Abe, Toshi</creatorcontrib><creatorcontrib>Chitose, Shun‐ichi</creatorcontrib><creatorcontrib>Umeno, Hirohito</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ono, Takeharu</au><au>Azuma, Koichi</au><au>Kawahara, Akihiko</au><au>Kakuma, Tatsuyuki</au><au>Sato, Fumihiko</au><au>Akiba, Jun</au><au>Tanaka, Norimitsu</au><au>Abe, Toshi</au><au>Chitose, Shun‐ichi</au><au>Umeno, Hirohito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of CD8/FOXP3 ratio combined with PD‐L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-12</date><risdate>2020</risdate><volume>42</volume><issue>12</issue><spage>3518</spage><epage>3530</epage><pages>3518-3530</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Little is known about immune‐related radiosensitivity in patients with squamous cell carcinoma of the larynx (SCC‐L) treated with radiation therapy (RT).
Methods
We retrospectively reviewed 91 patients with SCC‐L treated with RT or chemoradiation therapy and performed immunohistochemical examination to analyze PD‐L1 level on tumor cells, CD4+ tumor‐infiltrating lymphocytes (TILs), CD8+TIL, and FOXP3+TIL using pretreated biopsy specimens. The association between these immune‐related parameters and radiosensitivity was evaluated.
Results
Multivariate analyses showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression was an independent and significant favorable predictive factor for local control, compared with the other groups.
Conclusions
We showed that high CD8/FOXP3 ratio combined with negative PD‐L1 expression might be a useful biomarker of radiosensitivity in patients with SCC‐L receiving definitive RT. We propose that coassessment of CD8/FOXP3 ratio and PD‐L1 expression level in tumor cells can help predict potential radiosensitivity in patients with SCC‐L.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32808399</pmid><doi>10.1002/hed.26416</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2414-7034</orcidid><orcidid>https://orcid.org/0000-0002-9307-2331</orcidid></addata></record> |
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| ispartof | Head & neck, 2020-12, Vol.42 (12), p.3518-3530 |
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| subjects | B7-H1 Antigen Biopsy CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes CD8/FOXP3 ratio Chemoradiotherapy Forkhead Transcription Factors - genetics Foxp3 protein Head and neck Head and Neck Neoplasms Humans Laryngeal cancer Larynx local control Lymphocytes PD-L1 protein PD‐L1 expression Prognosis Radiation therapy Radiation Tolerance Radiosensitivity Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Tumor cells |
| title | Predictive value of CD8/FOXP3 ratio combined with PD‐L1 expression for radiosensitivity in patients with squamous cell carcinoma of the larynx receiving definitive radiation therapy |
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