Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy

Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patie...

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Veröffentlicht in:	Head & neck 2020-12, Vol.42 (12), p.3601-3608
Hauptverfasser:	Stanisz, Isabella, Janik, Stefan, Grasl, Matthäus Christoph, Erovic, Boban M.
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Sprache:	eng
Schlagworte:	follow‐up Head & neck cancer Head and neck head and neck carcinoma Laryngeal cancer Laryngeal carcinoma Morbidity panendoscopy Patients Radiation therapy radiotherapy Surgery
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container_title	Head & neck
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creator	Stanisz, Isabella Janik, Stefan Grasl, Matthäus Christoph Erovic, Boban M.
description	Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy, a negative histopathological result was significantly higher in patients after radiotherapy (n = 394) compared to patients after surgery (n = 195) alone (odds ratio [OR] 0.4424, 95% confidence interval [CI] 0.2081‐0.969, P = .05). After radiotherapy, a suspicious radiological result was not significantly linked to recurrence (OR 1.461, 95% CI 0.7126‐3.021, P = .37). Clinical investigation was the best predictive parameter for detecting recurrent disease after radiation therapy (OR 4.061, 95% CI 2.268‐7.113, P =
doi_str_mv	10.1002/hed.26433
format	Article
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The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy, a negative histopathological result was significantly higher in patients after radiotherapy (n = 394) compared to patients after surgery (n = 195) alone (odds ratio [OR] 0.4424, 95% confidence interval [CI] 0.2081‐0.969, P = .05). After radiotherapy, a suspicious radiological result was not significantly linked to recurrence (OR 1.461, 95% CI 0.7126‐3.021, P = .37). Clinical investigation was the best predictive parameter for detecting recurrent disease after radiation therapy (OR 4.061, 95% CI 2.268‐7.113, P = <.0001). Conclusions Our results suggest that in the first 6 months after radiotherapy, emphasis should be placed on clinical evaluation during follow‐up.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26433</identifier><identifier>PMID: 32827202</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>follow‐up ; Head & neck cancer ; Head and neck ; head and neck carcinoma ; Laryngeal cancer ; Laryngeal carcinoma ; Morbidity ; panendoscopy ; Patients ; Radiation therapy ; radiotherapy ; Surgery</subject><ispartof>Head & neck, 2020-12, Vol.42 (12), p.3601-3608</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-3582c109b78049aa15d7c468d577cdba97cb341a111522ef45e5e46691e635c3</citedby><cites>FETCH-LOGICAL-c3533-3582c109b78049aa15d7c468d577cdba97cb341a111522ef45e5e46691e635c3</cites><orcidid>0000-0001-5388-3503</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.26433$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.26433$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32827202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanisz, Isabella</creatorcontrib><creatorcontrib>Janik, Stefan</creatorcontrib><creatorcontrib>Grasl, Matthäus Christoph</creatorcontrib><creatorcontrib>Erovic, Boban M.</creatorcontrib><title>Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy, a negative histopathological result was significantly higher in patients after radiotherapy (n = 394) compared to patients after surgery (n = 195) alone (odds ratio [OR] 0.4424, 95% confidence interval [CI] 0.2081‐0.969, P = .05). After radiotherapy, a suspicious radiological result was not significantly linked to recurrence (OR 1.461, 95% CI 0.7126‐3.021, P = .37). Clinical investigation was the best predictive parameter for detecting recurrent disease after radiation therapy (OR 4.061, 95% CI 2.268‐7.113, P = <.0001). Conclusions Our results suggest that in the first 6 months after radiotherapy, emphasis should be placed on clinical evaluation during follow‐up.</description><subject>follow‐up</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>head and neck carcinoma</subject><subject>Laryngeal cancer</subject><subject>Laryngeal carcinoma</subject><subject>Morbidity</subject><subject>panendoscopy</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>radiotherapy</subject><subject>Surgery</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1OwzAQRi0EoqWw4ALIEisWaf2XOFmiUihSJRDq3nIdp02V2sFOVGXHETgjJ8El7ZLVjEZP38w8AG4xGmOEyGSj8zFJGKVnYIhRxiNEGT8_9IxGFHE2AFfebxFCNGHkEgwoSQkniAzBx7s02uTWK1t3MG9dadawsFVl9z9f320NSwMr6Tqz1rKCSjpVGruTsJZNqU3joSwa7aCTeWmbjXay7q7BRSErr2-OdQSWz7PldB4t3l5ep4-LSNGYhrvilKhw7YqniGVS4jjniiVpHnOu8pXMuFpRhiXGOCZEFyzWsWZJkmGd0FjREbjvY2tnP1vtG7G1rTNhoyAsQThLESeBeugp5az3TheiduUuPCQwEgd5IsgTf_ICe3dMbFe7MD2RJ1sBmPTAvqx093-SmM-e-shf9Pd5NQ</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Stanisz, Isabella</creator><creator>Janik, Stefan</creator><creator>Grasl, Matthäus Christoph</creator><creator>Erovic, Boban M.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-5388-3503</orcidid></search><sort><creationdate>202012</creationdate><title>Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy</title><author>Stanisz, Isabella ; Janik, Stefan ; Grasl, Matthäus Christoph ; Erovic, Boban M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-3582c109b78049aa15d7c468d577cdba97cb341a111522ef45e5e46691e635c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>follow‐up</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>head and neck carcinoma</topic><topic>Laryngeal cancer</topic><topic>Laryngeal carcinoma</topic><topic>Morbidity</topic><topic>panendoscopy</topic><topic>Patients</topic><topic>Radiation therapy</topic><topic>radiotherapy</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanisz, Isabella</creatorcontrib><creatorcontrib>Janik, Stefan</creatorcontrib><creatorcontrib>Grasl, Matthäus Christoph</creatorcontrib><creatorcontrib>Erovic, Boban M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanisz, Isabella</au><au>Janik, Stefan</au><au>Grasl, Matthäus Christoph</au><au>Erovic, Boban M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-12</date><risdate>2020</risdate><volume>42</volume><issue>12</issue><spage>3601</spage><epage>3608</epage><pages>3601-3608</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background Early detection of a recurrent disease remains essential during follow‐up to improve outcome and reduce morbidity. The purpose of this study was to evaluate the adequacy of panendoscopy after radiotherapy for recurrent laryngeal carcinoma. Methods In this retrospective analysis, 623 patients were included. Clinical and radiological examinations were compared to pathohistological results of panendoscopy and clinical outcome. Results In the first 6 months after therapy, a negative histopathological result was significantly higher in patients after radiotherapy (n = 394) compared to patients after surgery (n = 195) alone (odds ratio [OR] 0.4424, 95% confidence interval [CI] 0.2081‐0.969, P = .05). After radiotherapy, a suspicious radiological result was not significantly linked to recurrence (OR 1.461, 95% CI 0.7126‐3.021, P = .37). Clinical investigation was the best predictive parameter for detecting recurrent disease after radiation therapy (OR 4.061, 95% CI 2.268‐7.113, P = <.0001). Conclusions Our results suggest that in the first 6 months after radiotherapy, emphasis should be placed on clinical evaluation during follow‐up.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32827202</pmid><doi>10.1002/hed.26433</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5388-3503</orcidid></addata></record>
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subjects	follow‐up Head & neck cancer Head and neck head and neck carcinoma Laryngeal cancer Laryngeal carcinoma Morbidity panendoscopy Patients Radiation therapy radiotherapy Surgery
title	Panendoscopy during follow‐up in laryngeal carcinoma patients after radiotherapy
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