Endothelin-1 stimulates preadipocyte growth via the PKC, STAT3, AMPK, c-JUN, ERK, sphingosine kinase, and sphingomyelinase pathways

Endothelin (ET)-1 regulates adipogenesis and the endocrine activity of fat cells. However, relatively little is known about the ET-1 signaling pathway in preadipocyte growth. We used 3T3-L1 preadipocytes to investigate the signaling pathways involved in ET-1 modulation of preadipocyte proliferation....

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2020-11, Vol.319 (5), p.C839-C857
Hauptverfasser:	Siao, An-Ci, Lin, Yen-Yue, Shih, Li-Jane, Tsuei, Yi-Wei, Chuu, Chih-Pin, Kuo, Yow-Chii, Kao, Yung-Hsi
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Adipogenesis AKT protein Animals Bromodeoxyuridine Butadienes - pharmacology c-Jun protein Cell Differentiation Cell growth Cell proliferation Cell Proliferation - drug effects Dose-Response Relationship, Drug Endothelin 1 Endothelin Receptor Antagonists - pharmacology Endothelin-1 - pharmacology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation Imidazoles - pharmacology Janus kinase 2 JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Kinases MAP kinase Mice Nitriles - pharmacology Oligopeptides - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Piperidines - pharmacology Preadipocytes Protein kinase C Protein Kinase C - genetics Protein Kinase C - metabolism Pyridines - pharmacology Receptors, Endothelin - genetics Receptors, Endothelin - metabolism Signal Transduction Sphingomyelin phosphodiesterase Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Sphingosine kinase Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription factors
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