Research progress on the inhibition of enzymes by polyoxometalates
Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus, and so on. The mechanism of their action at the molecular level is basically unknown. However, some...
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| Veröffentlicht in: | Inorganic chemistry frontiers 2020-11, Vol.7 (22), p.432-4332 |
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| creator | Zhao, Meijuan Chen, Xiangsong Chi, Guoxiang Shuai, Die Wang, Li Chen, Bingnian Li, Jian |
| description | Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus, and so on. The mechanism of their action at the molecular level is basically unknown. However, some studies have shown that the inhibitory effect of POMs on several enzyme families (such as α-glucosidase, tyrosinase, protein kinase or exonuclease) may be related to the pharmacological properties of POMs. In addition, POMs also inhibited sialyltransferase, thiotransferase, deacetylase and virus reverse enzyme to different degrees. Combining the results of research groups, it was found the structure and composition of POMs may indirectly affect their inhibition ability. Therefore, this paper reviews the inhibitory effects of POMs on various enzymes in order to contribute to the application of polyoxometalates in biomedicine.
Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus and so on. |
| doi_str_mv | 10.1039/d0qi00860e |
| format | Article |
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Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus and so on.</description><identifier>ISSN: 2052-1553</identifier><identifier>ISSN: 2052-1545</identifier><identifier>EISSN: 2052-1553</identifier><identifier>DOI: 10.1039/d0qi00860e</identifier><language>eng</language><publisher>London: Royal Society of Chemistry</publisher><subject>Alzheimer's disease ; Coordination compounds ; Enzymes ; Glucosidase ; Inorganic chemistry ; Kinases ; Polyoxometallates ; Tyrosinase ; Viruses</subject><ispartof>Inorganic chemistry frontiers, 2020-11, Vol.7 (22), p.432-4332</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-fe4c3b119e2b0514102a00d5dfa752729638ae6ddd4bef4e18013a9382a0198b3</citedby><cites>FETCH-LOGICAL-c317t-fe4c3b119e2b0514102a00d5dfa752729638ae6ddd4bef4e18013a9382a0198b3</cites><orcidid>0000-0002-4835-7792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhao, Meijuan</creatorcontrib><creatorcontrib>Chen, Xiangsong</creatorcontrib><creatorcontrib>Chi, Guoxiang</creatorcontrib><creatorcontrib>Shuai, Die</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Chen, Bingnian</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><title>Research progress on the inhibition of enzymes by polyoxometalates</title><title>Inorganic chemistry frontiers</title><description>Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus, and so on. The mechanism of their action at the molecular level is basically unknown. However, some studies have shown that the inhibitory effect of POMs on several enzyme families (such as α-glucosidase, tyrosinase, protein kinase or exonuclease) may be related to the pharmacological properties of POMs. In addition, POMs also inhibited sialyltransferase, thiotransferase, deacetylase and virus reverse enzyme to different degrees. Combining the results of research groups, it was found the structure and composition of POMs may indirectly affect their inhibition ability. Therefore, this paper reviews the inhibitory effects of POMs on various enzymes in order to contribute to the application of polyoxometalates in biomedicine.
Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus and so on.</description><subject>Alzheimer's disease</subject><subject>Coordination compounds</subject><subject>Enzymes</subject><subject>Glucosidase</subject><subject>Inorganic chemistry</subject><subject>Kinases</subject><subject>Polyoxometallates</subject><subject>Tyrosinase</subject><subject>Viruses</subject><issn>2052-1553</issn><issn>2052-1545</issn><issn>2052-1553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpN0E1Lw0AQBuBFFCy1F-_CgjchOrObzcdRa9VCQRQ9h00yMSlJNt1NwfjrjUbU08zAw8zwMnaKcIkg46scdhVAFAAdsJkAJTxUSh7-64_ZwrktACD6gAHM2M0zOdI2K3lnzZsl57hpeV8Sr9qySqu-GkdTcGo_hoYcTwfemXow76ahXte6J3fCjgpdO1r81Dl7vVu9LB-8zeP9enm98TKJYe8V5GcyRYxJpKDQRxAaIFd5oUMlQhEHMtIU5Hnup1T4hBGg1LGMRoZxlMo5O5_2jp_u9uT6ZGv2th1PJsJXUSzDIJSjuphUZo1zloqks1Wj7ZAgJF8xJbfwtP6OaTXiswlbl_26vxjlJ2U1Y4A</recordid><startdate>20201121</startdate><enddate>20201121</enddate><creator>Zhao, Meijuan</creator><creator>Chen, Xiangsong</creator><creator>Chi, Guoxiang</creator><creator>Shuai, Die</creator><creator>Wang, Li</creator><creator>Chen, Bingnian</creator><creator>Li, Jian</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0002-4835-7792</orcidid></search><sort><creationdate>20201121</creationdate><title>Research progress on the inhibition of enzymes by polyoxometalates</title><author>Zhao, Meijuan ; Chen, Xiangsong ; Chi, Guoxiang ; Shuai, Die ; Wang, Li ; Chen, Bingnian ; Li, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-fe4c3b119e2b0514102a00d5dfa752729638ae6ddd4bef4e18013a9382a0198b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alzheimer's disease</topic><topic>Coordination compounds</topic><topic>Enzymes</topic><topic>Glucosidase</topic><topic>Inorganic chemistry</topic><topic>Kinases</topic><topic>Polyoxometallates</topic><topic>Tyrosinase</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Meijuan</creatorcontrib><creatorcontrib>Chen, Xiangsong</creatorcontrib><creatorcontrib>Chi, Guoxiang</creatorcontrib><creatorcontrib>Shuai, Die</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Chen, Bingnian</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Inorganic chemistry frontiers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Meijuan</au><au>Chen, Xiangsong</au><au>Chi, Guoxiang</au><au>Shuai, Die</au><au>Wang, Li</au><au>Chen, Bingnian</au><au>Li, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research progress on the inhibition of enzymes by polyoxometalates</atitle><jtitle>Inorganic chemistry frontiers</jtitle><date>2020-11-21</date><risdate>2020</risdate><volume>7</volume><issue>22</issue><spage>432</spage><epage>4332</epage><pages>432-4332</pages><issn>2052-1553</issn><issn>2052-1545</issn><eissn>2052-1553</eissn><abstract>Polyoxometalates (POMs) are a kind of inorganic cluster metal complex with various biological activities, such as anti-Alzheimer's disease, antibacterial, anti-cancer, anti-diabetes, anti-virus, and so on. The mechanism of their action at the molecular level is basically unknown. However, some studies have shown that the inhibitory effect of POMs on several enzyme families (such as α-glucosidase, tyrosinase, protein kinase or exonuclease) may be related to the pharmacological properties of POMs. In addition, POMs also inhibited sialyltransferase, thiotransferase, deacetylase and virus reverse enzyme to different degrees. Combining the results of research groups, it was found the structure and composition of POMs may indirectly affect their inhibition ability. Therefore, this paper reviews the inhibitory effects of POMs on various enzymes in order to contribute to the application of polyoxometalates in biomedicine.
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| language | eng |
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| source | Royal Society Of Chemistry Journals |
| subjects | Alzheimer's disease Coordination compounds Enzymes Glucosidase Inorganic chemistry Kinases Polyoxometallates Tyrosinase Viruses |
| title | Research progress on the inhibition of enzymes by polyoxometalates |
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