Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives

Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives

A series of novel quinazolinone derivatives was designed and synthesized. The antiproliferative activities were evaluated in vitro using MTT assay against hepatocellular carcinoma (HepG‐2) and mammary gland breast cancer (MCF‐7). The preliminary bioassay results demonstrated that tested compounds ex...

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Veröffentlicht in:Journal of heterocyclic chemistry 2020-11, Vol.57 (11), p.3898-3906
Hauptverfasser: Salem, Marwa Sayed, Al‐Mabrook, Selima Ali Mohamed, El‐Hashash, Maher Abd El‐Aziz Mahmoud
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Sprache:eng
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Antiproliferatives
Derivatives
Doxorubicin
Mammary glands
Triazoles
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container_issue 11
container_start_page 3898
container_title Journal of heterocyclic chemistry
container_volume 57
creator Salem, Marwa Sayed
Al‐Mabrook, Selima Ali Mohamed
El‐Hashash, Maher Abd El‐Aziz Mahmoud
description A series of novel quinazolinone derivatives was designed and synthesized. The antiproliferative activities were evaluated in vitro using MTT assay against hepatocellular carcinoma (HepG‐2) and mammary gland breast cancer (MCF‐7). The preliminary bioassay results demonstrated that tested compounds exhibited antiproliferation with various degrees. Triazole moiety enhanced the activity against the two cell lines when incorporating with quinazolinone moiety in a single molecular framework. Acetohydrazide‐quinazolinone derivative showed strong activity against the two cancer cells comparable to that of doxorubicin. Biological evaluation indicated that all the tested compounds possessed antiproliferative activity with certain degrees.
doi_str_mv 10.1002/jhet.4096
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subjects Antiproliferatives
Derivatives
Doxorubicin
Mammary glands
Triazoles
title Synthesis and antiproliferative evaluation of some novel quinazolin‐4(3H)‐one derivatives
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