Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

Hexavelant chromium (Cr (V1)) is a widely distributed environmental pollutant inducing damage in different organs of human and animals. The current study was designed to investigate the mechanistic role of rosmarinic acid (RA) to diminish chromium‐induced hepatorenal oxidative damage and preneoplast...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2020-11, Vol.34 (11), p.e22579-n/a
Hauptverfasser:	Khalaf, Azem A., Hassanen, Eman I., Ibrahim, Marwa A., Tohamy, Adel F., Aboseada, Mahmoud A., Hassan, Hossam M., Zaki, Amr R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Antigens Antioxidants Caspase Chromium Chromium - toxicity Cinnamates - pharmacology Damage Dental materials Deoxyribonucleic acid Depsides - pharmacology DNA DNA - drug effects DNA Damage Glutathione histopathology Kidney - drug effects Kidneys Lesions Liver Liver - drug effects Magnetic resonance spectroscopy Male Malondialdehyde NBN NMR Nrf2 NRF2 protein Nuclear magnetic resonance Organs Oxidants Oxidative Stress - drug effects Oxidizing agents PCNA Placenta Pollutants Potassium Potassium dichromate Proliferating cell nuclear antigen Rats Rats, Wistar Rodents Rosmarinic Acid Toxicity
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