Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

ObjectiveSporadic early-onset colorectal cancer (EOCRC) has bad prognosis, yet is poorly represented by cell line models. We examine the key mutational and transcriptomic alterations in an organoid biobank enriched in EOCRCs.DesignWe established paired cancer (n=32) and normal organoids (n=18) from...

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Veröffentlicht in:	Gut 2020-12, Vol.69 (12), p.2165-2179
Hauptverfasser:	Yan, Helen H N, Siu, Hoi Cheong, Ho, Siu Lun, Yue, Sarah S K, Gao, Yang, Tsui, Wai Yin, Chan, Dessy, Chan, April S, Wong, Jason W H, Man, Alice H Y, Lee, Bernard C H, Chan, Annie S Y, Chan, Anthony K W, Hui, Ho Sang, Cheung, Arthur K L, Law, Wai Lun, Lo, Oswens S H, Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Adenomatous Polyposis Coli Protein - genetics Age Biobanks Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein Receptors, Type I - genetics Cancer Cell Adhesion Molecules - genetics Cell culture Colon colon carcinogenesis Colorectal cancer colorectal cancer genes Colorectal carcinoma Colorectal Neoplasms - genetics CRISPR CRISPR-Cas Systems Early-onset colon cancer Gene expression Gene Expression Profiling Gene Fusion Genetic engineering Genetic Profile Genomes Humans Leukemia Lymphatic system Models, Genetic Mutants Mutation organoid models Organoids Organoids - pathology Patients Phenotypes Proofreading R-spondin fusion Receptor Protein-Tyrosine Kinases - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics RNF43 serrated neoplasia Smad4 protein Smad4 Protein - genetics Thrombospondins - genetics Tissue Banks Transcription Tumors Ubiquitin-Protein Ligases - genetics Up-Regulation Whole Exome Sequencing Wnt protein
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