Ameliorative effects of L-glutamine on haematological parameters in heat-stressed Red Sokoto goats
The aim of the study was to evaluate haematological responses in Red Sokoto goats (RSGs) administered with L-glutamine during the hot-dry season. Experimental animals included 28 clinically healthy RSGs divided into treated group (n = 14); each administered L-glutamine at 0.2 g/kg body weight, disso...
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| description | The aim of the study was to evaluate haematological responses in Red Sokoto goats (RSGs) administered with L-glutamine during the hot-dry season. Experimental animals included 28 clinically healthy RSGs divided into treated group (n = 14); each administered L-glutamine at 0.2 g/kg body weight, dissolved in 10 mL distilled water, and control group (n = 14); each administered 10 mL distilled water, per os once daily for 21 days. The ambient temperature and relative humidity recorded daily for 4 weeks were used to calculate the temperature-humidity index. Three millilitres of blood sample was collected from each goat by jugular venipuncture for haematology, while rectal temperature (RT), heart rate (HR) and respiratory rate (RR) were also measured once weekly at weeks 0 (before), 1, 2, 3 (during) and 4 (after L-glutamine administration). The haematological, RT, HR and RR data obtained weekly were analysed using repeated-measures one-way ANOVA, followed by Tukey's post-hoc test to evaluate differences between periods, and between treated and control groups. The PCV, haemoglobin concentration and RBC count were higher (P |
| doi_str_mv | 10.1016/j.jtherbio.2020.102571 |
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•The hot-dry season in the Northern Guinea Savanna zone of Nigeria imposes heat stress on livestock.•Heat stress negatively impacts the haematological parameters of Red Sokoto goats.•L-glutamine ameliorates environmental heat stress-induced changes in haematological parameters in Red Sokoto goats.</description><identifier>ISSN: 0306-4565</identifier><identifier>EISSN: 1879-0992</identifier><identifier>DOI: 10.1016/j.jtherbio.2020.102571</identifier><identifier>PMID: 32479401</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Body Temperature ; Body weight ; Female ; Glutamine ; Glutamine - therapeutic use ; Goats - physiology ; Haematological ; Heart rate ; Heart Rate - drug effects ; Heat stress ; Heat Stress Disorders - blood ; Heat Stress Disorders - drug therapy ; Heat Stress Disorders - physiopathology ; Heat Stress Disorders - veterinary ; Heat-Shock Response - drug effects ; Hematologic Tests ; Hematology ; Hemoglobin ; Hot Temperature - adverse effects ; Hot-dry season ; Humidity ; L-glutamine ; Male ; Red Sokoto goats ; Relative humidity ; Respiration ; Respiratory Rate - drug effects</subject><ispartof>Journal of thermal biology, 2020-05, Vol.90, p.102571-8, Article 102571</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV May 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-f0a919bb5ef153a0985f9c72916f5be9e5eae10de3cb386f0cc8580dc8d5ee453</citedby><cites>FETCH-LOGICAL-c396t-f0a919bb5ef153a0985f9c72916f5be9e5eae10de3cb386f0cc8580dc8d5ee453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jtherbio.2020.102571$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32479401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ocheja, Ohiemi Benjamin</creatorcontrib><creatorcontrib>Ayo, Joseph Olusegun</creatorcontrib><creatorcontrib>Aluwong, Tagang</creatorcontrib><creatorcontrib>Minka, Ndazo Salka</creatorcontrib><title>Ameliorative effects of L-glutamine on haematological parameters in heat-stressed Red Sokoto goats</title><title>Journal of thermal biology</title><addtitle>J Therm Biol</addtitle><description>The aim of the study was to evaluate haematological responses in Red Sokoto goats (RSGs) administered with L-glutamine during the hot-dry season. Experimental animals included 28 clinically healthy RSGs divided into treated group (n = 14); each administered L-glutamine at 0.2 g/kg body weight, dissolved in 10 mL distilled water, and control group (n = 14); each administered 10 mL distilled water, per os once daily for 21 days. The ambient temperature and relative humidity recorded daily for 4 weeks were used to calculate the temperature-humidity index. Three millilitres of blood sample was collected from each goat by jugular venipuncture for haematology, while rectal temperature (RT), heart rate (HR) and respiratory rate (RR) were also measured once weekly at weeks 0 (before), 1, 2, 3 (during) and 4 (after L-glutamine administration). The haematological, RT, HR and RR data obtained weekly were analysed using repeated-measures one-way ANOVA, followed by Tukey's post-hoc test to evaluate differences between periods, and between treated and control groups. The PCV, haemoglobin concentration and RBC count were higher (P < 0.05) in the treated group compared to the control group during the period of L-glutamine administration. These differences were sustained till week 4. Beginning from week 1 of the study, the total leucocyte count in treated group (10.10 ± 0.25 × 103/μL) was higher (P < 0.05) than the count in control group (7.23 ± 0.41 × 103/μL), this trend was also maintained throughout the study. The neutrophil:lymphocyte ratio during weeks 3 and 4 of the experiment was lower (P < 0.05) in the treated compared to the control group. RT was lower (P < 0.05) in treated group than the control group. In conclusion, L-glutamine administration ameliorated the adverse effects of heat stress on the haematological parameters in RSGs during the hot-dry season.
•The hot-dry season in the Northern Guinea Savanna zone of Nigeria imposes heat stress on livestock.•Heat stress negatively impacts the haematological parameters of Red Sokoto goats.•L-glutamine ameliorates environmental heat stress-induced changes in haematological parameters in Red Sokoto goats.</description><subject>Animals</subject><subject>Body Temperature</subject><subject>Body weight</subject><subject>Female</subject><subject>Glutamine</subject><subject>Glutamine - therapeutic use</subject><subject>Goats - physiology</subject><subject>Haematological</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Heat stress</subject><subject>Heat Stress Disorders - blood</subject><subject>Heat Stress Disorders - drug therapy</subject><subject>Heat Stress Disorders - physiopathology</subject><subject>Heat Stress Disorders - veterinary</subject><subject>Heat-Shock Response - drug effects</subject><subject>Hematologic Tests</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Hot Temperature - adverse effects</subject><subject>Hot-dry season</subject><subject>Humidity</subject><subject>L-glutamine</subject><subject>Male</subject><subject>Red Sokoto goats</subject><subject>Relative humidity</subject><subject>Respiration</subject><subject>Respiratory Rate - drug effects</subject><issn>0306-4565</issn><issn>1879-0992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqt_oQQ8b02ym93NzVL8goLgxzlks5M2625Tk7Tgvzel1auHYWDmnXlnHoQmlEwpoeVtN-3iCnxj3ZQRti8yXtETNKJ1JTIiBDtFI5KTMit4yS_QZQgdIZTnnJyji5wVlSgIHaFmNkBvnVfR7gCDMaBjwM7gRbbst1ENdg3YrfFKwaCi693SatXjjfJqgAg-YJuaoGIWoocQoMWvKd7cp4sOL52K4QqdGdUHuD7mMfp4uH-fP2WLl8fn-WyR6VyUMTNECSqahoNJZyoiam6ErpigpeENCOCggJIWct3kdWmI1jWvSavrlgMUPB-jm8PejXdfWwhRdm7r18lSsoJXoqwYZ0lVHlTauxA8GLnxdlD-W1Ii92hlJ3_Ryj1aeUCbBifH9dtmgPZv7JdlEtwdBJCe3FnwMmgLaw2t9YmqbJ39z-MHVeyPHQ</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Ocheja, Ohiemi Benjamin</creator><creator>Ayo, Joseph Olusegun</creator><creator>Aluwong, Tagang</creator><creator>Minka, Ndazo Salka</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7SS</scope><scope>7TK</scope><scope>7TS</scope></search><sort><creationdate>202005</creationdate><title>Ameliorative effects of L-glutamine on haematological parameters in heat-stressed Red Sokoto goats</title><author>Ocheja, Ohiemi Benjamin ; Ayo, Joseph Olusegun ; Aluwong, Tagang ; Minka, Ndazo Salka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-f0a919bb5ef153a0985f9c72916f5be9e5eae10de3cb386f0cc8580dc8d5ee453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Body Temperature</topic><topic>Body weight</topic><topic>Female</topic><topic>Glutamine</topic><topic>Glutamine - therapeutic use</topic><topic>Goats - physiology</topic><topic>Haematological</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Heat stress</topic><topic>Heat Stress Disorders - blood</topic><topic>Heat Stress Disorders - drug therapy</topic><topic>Heat Stress Disorders - physiopathology</topic><topic>Heat Stress Disorders - veterinary</topic><topic>Heat-Shock Response - drug effects</topic><topic>Hematologic Tests</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Hot Temperature - adverse effects</topic><topic>Hot-dry season</topic><topic>Humidity</topic><topic>L-glutamine</topic><topic>Male</topic><topic>Red Sokoto goats</topic><topic>Relative humidity</topic><topic>Respiration</topic><topic>Respiratory Rate - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ocheja, Ohiemi Benjamin</creatorcontrib><creatorcontrib>Ayo, Joseph Olusegun</creatorcontrib><creatorcontrib>Aluwong, Tagang</creatorcontrib><creatorcontrib>Minka, Ndazo Salka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><jtitle>Journal of thermal biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ocheja, Ohiemi Benjamin</au><au>Ayo, Joseph Olusegun</au><au>Aluwong, Tagang</au><au>Minka, Ndazo Salka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ameliorative effects of L-glutamine on haematological parameters in heat-stressed Red Sokoto goats</atitle><jtitle>Journal of thermal biology</jtitle><addtitle>J Therm Biol</addtitle><date>2020-05</date><risdate>2020</risdate><volume>90</volume><spage>102571</spage><epage>8</epage><pages>102571-8</pages><artnum>102571</artnum><issn>0306-4565</issn><eissn>1879-0992</eissn><abstract>The aim of the study was to evaluate haematological responses in Red Sokoto goats (RSGs) administered with L-glutamine during the hot-dry season. Experimental animals included 28 clinically healthy RSGs divided into treated group (n = 14); each administered L-glutamine at 0.2 g/kg body weight, dissolved in 10 mL distilled water, and control group (n = 14); each administered 10 mL distilled water, per os once daily for 21 days. The ambient temperature and relative humidity recorded daily for 4 weeks were used to calculate the temperature-humidity index. Three millilitres of blood sample was collected from each goat by jugular venipuncture for haematology, while rectal temperature (RT), heart rate (HR) and respiratory rate (RR) were also measured once weekly at weeks 0 (before), 1, 2, 3 (during) and 4 (after L-glutamine administration). The haematological, RT, HR and RR data obtained weekly were analysed using repeated-measures one-way ANOVA, followed by Tukey's post-hoc test to evaluate differences between periods, and between treated and control groups. The PCV, haemoglobin concentration and RBC count were higher (P < 0.05) in the treated group compared to the control group during the period of L-glutamine administration. These differences were sustained till week 4. Beginning from week 1 of the study, the total leucocyte count in treated group (10.10 ± 0.25 × 103/μL) was higher (P < 0.05) than the count in control group (7.23 ± 0.41 × 103/μL), this trend was also maintained throughout the study. The neutrophil:lymphocyte ratio during weeks 3 and 4 of the experiment was lower (P < 0.05) in the treated compared to the control group. RT was lower (P < 0.05) in treated group than the control group. In conclusion, L-glutamine administration ameliorated the adverse effects of heat stress on the haematological parameters in RSGs during the hot-dry season.
•The hot-dry season in the Northern Guinea Savanna zone of Nigeria imposes heat stress on livestock.•Heat stress negatively impacts the haematological parameters of Red Sokoto goats.•L-glutamine ameliorates environmental heat stress-induced changes in haematological parameters in Red Sokoto goats.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>32479401</pmid><doi>10.1016/j.jtherbio.2020.102571</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Body Temperature Body weight Female Glutamine Glutamine - therapeutic use Goats - physiology Haematological Heart rate Heart Rate - drug effects Heat stress Heat Stress Disorders - blood Heat Stress Disorders - drug therapy Heat Stress Disorders - physiopathology Heat Stress Disorders - veterinary Heat-Shock Response - drug effects Hematologic Tests Hematology Hemoglobin Hot Temperature - adverse effects Hot-dry season Humidity L-glutamine Male Red Sokoto goats Relative humidity Respiration Respiratory Rate - drug effects |
| title | Ameliorative effects of L-glutamine on haematological parameters in heat-stressed Red Sokoto goats |
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