Aporphinoid Alkaloids Derivatives as Selective Cholinesterases Inhibitors: Biological Evaluation and Docking Study

Alzheimer's dementia is a neurodegenerative disease that affects the elderly population and causes memory impairment and cognitive deficit. Manifestation of this disease is associated to acetylcholine decrease; thus, Cholinesterase inhibition is the main therapeutic strategy for the treatment o...

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Veröffentlicht in:	Molecular informatics 2020-11, Vol.39 (11), p.n/a
Hauptverfasser:	Cavallaro, Valeria, Murray, Ana Paula, Pungitore, Carlos Rodolfo, Gutiérrez, Lucas Joel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alkaloids Alzheimer's disease Aporphinoid Bonding strength Butyrylcholinesterase Cholinesterase Cognitive ability Dementia disorders Galantamine Hydrogen bonding Hydrogen bonds Inhibitors Medical treatment Molecular modelling Neurodegenerative diseases Older people Selectivity
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