Trigger‐dependent differences determine therapeutic outcome in murine primary hemophagocytic lymphohistiocytosis

Familial hemophagocytic lymphohistiocytosis (FHL) is a hyperinflammatory syndrome affecting patients with genetic cytotoxicity defects. Perforin‐deficient (PKO) mice recapitulate the full clinical picture of FHL after infection with lymphocytic choriomeningitis virus (LCMV). Hyperactivated CD8+ T ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2020-11, Vol.50 (11), p.1770-1782
Hauptverfasser:	Gather, Ruth, Aichele, Peter, Goos, Nadja, Rohr, Jan, Pircher, Hanspeter, Kögl, Tamara, Zeiser, Robert, Hengel, Hartmut, Schmitt‐Gräff, Annette, Weaver, Casey, Ehl, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytopathology Cytotoxicity Disease Models, Animal hemophagocytic lymphohistiocytosis Histiocytosis immunodeficiency immunotherapy Infections Interferon Interferon-gamma - immunology Intravenous administration Killer Cells, Natural - immunology Lymphatic diseases Lymphocyte Activation - immunology lymphocyte cytotoxicity Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - immunology Lymphocytic choriomeningitis virus - immunology Lymphocytosis Lymphohistiocytosis, Hemophagocytic - immunology Mice Mice, Inbred C57BL Mice, Knockout Perforin Perforin - immunology Therapeutic applications Treatment Outcome viral infection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!