An assessment of serum‐dependent impacts on intracellular accumulation and genomic response of per‐ and polyfluoroalkyl substances in a placental trophoblast model

Per‐ and polyfluoroalkyl substances (PFAS), a class of environmental contaminants, have been detected in human placenta and cord blood. The mechanisms driving PFAS‐induced effects on the placenta and adverse pregnancy outcomes are not well understood. This study investigated the impact of perfluoroo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology 2020-12, Vol.35 (12), p.1395-1405
Hauptverfasser:	Bangma, Jacqueline, Szilagyi, John, Blake, Bevin E., Plazas, Cinthya, Kepper, Stewart, Fenton, Suzanne E., Fry, Rebecca
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Alkanesulfonic Acids - blood Alkanesulfonic Acids - metabolism Alkanesulfonic Acids - toxicity Apoptosis Apoptosis - drug effects Apoptosis - genetics Bioaccumulation - drug effects Bioaccumulation - genetics Caprylates - blood Caprylates - metabolism Caprylates - toxicity Cell culture Cell Culture Techniques Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cells Contaminants Cord blood Culture Media, Serum-Free Dimers Female Fluorocarbons - blood Fluorocarbons - metabolism Fluorocarbons - toxicity Gene expression Gene Expression - drug effects Genes GenX Humans in vitro Intracellular Mesenchyme Perfluorooctane sulfonic acid Perfluorooctanoic acid PFOA PFOS Placenta Placenta - drug effects Placenta - metabolism Pregnancy Reagents RNA, Messenger - genetics Serum Serum - chemistry Trophoblasts Trophoblasts - drug effects Trophoblasts - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!