Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B 12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)
The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B (DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen thera...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2020-11, Vol.79-80, p.111017 |
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| creator | Tan, Chuen Wen Ho, Liam Pock Kalimuddin, Shirin Cherng, Benjamin Pei Zhi Teh, Yii Ean Thien, Siew Yee Wong, Hei Man Tern, Paul Jie Wen Chandran, Manju Chay, Jason Wai Mun Nagarajan, Chandramouli Sultana, Rehena Low, Jenny Guek Hong Ng, Heng Joo |
| description | The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B
(DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.
This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D
, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B
upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.
Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively.
A vitamin D / magnesium / vitamin B
combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19. |
| doi_str_mv | 10.1016/j.nut.2020.111017 |
| format | Article |
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(DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.
This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D
, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B
upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.
Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively.
A vitamin D / magnesium / vitamin B
combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2020.111017</identifier><identifier>PMID: 33039952</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Age ; Aged ; Calciferol ; Cardiovascular disease ; Clinical deterioration ; Clinical trials ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - drug therapy ; COVID-19 - therapy ; Critical Care ; Cyanocobalamin ; Cytokines ; Diabetes ; Disease Progression ; Female ; Hospitalization ; Humans ; Hypertension ; Infections ; Magnesium ; Magnesium - therapeutic use ; Male ; Medical prognosis ; Microbiota ; Micronutrients - therapeutic use ; Middle Aged ; Minerals - therapeutic use ; Multivariate Analysis ; Normal distribution ; Observational studies ; Oxygen ; Oxygen Inhalation Therapy ; Oxygen therapy ; Pandemics ; Patients ; SARS-CoV-2 ; Severity of Illness Index ; Therapy ; Viral infections ; Vitamin B ; Vitamin B 12 - therapeutic use ; Vitamin B12 ; Vitamin D ; Vitamin D - therapeutic use ; Vitamin D3 ; Vitamins - therapeutic use</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2020-11, Vol.79-80, p.111017</ispartof><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33039952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, Chuen Wen</creatorcontrib><creatorcontrib>Ho, Liam Pock</creatorcontrib><creatorcontrib>Kalimuddin, Shirin</creatorcontrib><creatorcontrib>Cherng, Benjamin Pei Zhi</creatorcontrib><creatorcontrib>Teh, Yii Ean</creatorcontrib><creatorcontrib>Thien, Siew Yee</creatorcontrib><creatorcontrib>Wong, Hei Man</creatorcontrib><creatorcontrib>Tern, Paul Jie Wen</creatorcontrib><creatorcontrib>Chandran, Manju</creatorcontrib><creatorcontrib>Chay, Jason Wai Mun</creatorcontrib><creatorcontrib>Nagarajan, Chandramouli</creatorcontrib><creatorcontrib>Sultana, Rehena</creatorcontrib><creatorcontrib>Low, Jenny Guek Hong</creatorcontrib><creatorcontrib>Ng, Heng Joo</creatorcontrib><title>Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B 12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B
(DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.
This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D
, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B
upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.
Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively.
A vitamin D / magnesium / vitamin B
combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19.</description><subject>Age</subject><subject>Aged</subject><subject>Calciferol</subject><subject>Cardiovascular disease</subject><subject>Clinical deterioration</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - drug therapy</subject><subject>COVID-19 - therapy</subject><subject>Critical Care</subject><subject>Cyanocobalamin</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infections</subject><subject>Magnesium</subject><subject>Magnesium - therapeutic use</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Microbiota</subject><subject>Micronutrients - therapeutic use</subject><subject>Middle Aged</subject><subject>Minerals - therapeutic use</subject><subject>Multivariate Analysis</subject><subject>Normal distribution</subject><subject>Observational studies</subject><subject>Oxygen</subject><subject>Oxygen Inhalation Therapy</subject><subject>Oxygen therapy</subject><subject>Pandemics</subject><subject>Patients</subject><subject>SARS-CoV-2</subject><subject>Severity of Illness Index</subject><subject>Therapy</subject><subject>Viral infections</subject><subject>Vitamin B</subject><subject>Vitamin B 12 - therapeutic use</subject><subject>Vitamin B12</subject><subject>Vitamin D</subject><subject>Vitamin D - therapeutic use</subject><subject>Vitamin D3</subject><subject>Vitamins - therapeutic 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study to evaluate the effect of vitamin D, magnesium, and vitamin B 12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)</title><author>Tan, Chuen Wen ; Ho, Liam Pock ; Kalimuddin, Shirin ; Cherng, Benjamin Pei Zhi ; Teh, Yii Ean ; Thien, Siew Yee ; Wong, Hei Man ; Tern, Paul Jie Wen ; Chandran, Manju ; Chay, Jason Wai Mun ; Nagarajan, Chandramouli ; Sultana, Rehena ; Low, Jenny Guek Hong ; Ng, Heng Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p136t-154d47c81e21dffa4d09763726dcf1abd839e4dbe6471c035955c2757cf5cf073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Aged</topic><topic>Calciferol</topic><topic>Cardiovascular disease</topic><topic>Clinical deterioration</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Confidence intervals</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - drug therapy</topic><topic>COVID-19 - therapy</topic><topic>Critical Care</topic><topic>Cyanocobalamin</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infections</topic><topic>Magnesium</topic><topic>Magnesium - therapeutic use</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Microbiota</topic><topic>Micronutrients - therapeutic use</topic><topic>Middle Aged</topic><topic>Minerals - therapeutic use</topic><topic>Multivariate Analysis</topic><topic>Normal distribution</topic><topic>Observational studies</topic><topic>Oxygen</topic><topic>Oxygen Inhalation Therapy</topic><topic>Oxygen therapy</topic><topic>Pandemics</topic><topic>Patients</topic><topic>SARS-CoV-2</topic><topic>Severity of Illness Index</topic><topic>Therapy</topic><topic>Viral infections</topic><topic>Vitamin B</topic><topic>Vitamin B 12 - therapeutic use</topic><topic>Vitamin B12</topic><topic>Vitamin D</topic><topic>Vitamin D - therapeutic use</topic><topic>Vitamin D3</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Chuen Wen</creatorcontrib><creatorcontrib>Ho, Liam Pock</creatorcontrib><creatorcontrib>Kalimuddin, Shirin</creatorcontrib><creatorcontrib>Cherng, Benjamin Pei Zhi</creatorcontrib><creatorcontrib>Teh, Yii Ean</creatorcontrib><creatorcontrib>Thien, Siew Yee</creatorcontrib><creatorcontrib>Wong, Hei Man</creatorcontrib><creatorcontrib>Tern, Paul Jie Wen</creatorcontrib><creatorcontrib>Chandran, Manju</creatorcontrib><creatorcontrib>Chay, Jason Wai Mun</creatorcontrib><creatorcontrib>Nagarajan, Chandramouli</creatorcontrib><creatorcontrib>Sultana, Rehena</creatorcontrib><creatorcontrib>Low, Jenny Guek 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Chuen Wen</au><au>Ho, Liam Pock</au><au>Kalimuddin, Shirin</au><au>Cherng, Benjamin Pei Zhi</au><au>Teh, Yii Ean</au><au>Thien, Siew Yee</au><au>Wong, Hei Man</au><au>Tern, Paul Jie Wen</au><au>Chandran, Manju</au><au>Chay, Jason Wai Mun</au><au>Nagarajan, Chandramouli</au><au>Sultana, Rehena</au><au>Low, Jenny Guek Hong</au><au>Ng, Heng Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B 12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19)</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2020-11</date><risdate>2020</risdate><volume>79-80</volume><spage>111017</spage><pages>111017-</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B
(DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.
This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D
, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B
upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.
Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03-0.59) and 0.20 (95% CI, 0.04-0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively.
A vitamin D / magnesium / vitamin B
combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>33039952</pmid><doi>10.1016/j.nut.2020.111017</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2020-11, Vol.79-80, p.111017 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_journals_2457592724 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Age Aged Calciferol Cardiovascular disease Clinical deterioration Clinical trials Cohort analysis Cohort Studies Confidence intervals Coronaviridae Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - therapy Critical Care Cyanocobalamin Cytokines Diabetes Disease Progression Female Hospitalization Humans Hypertension Infections Magnesium Magnesium - therapeutic use Male Medical prognosis Microbiota Micronutrients - therapeutic use Middle Aged Minerals - therapeutic use Multivariate Analysis Normal distribution Observational studies Oxygen Oxygen Inhalation Therapy Oxygen therapy Pandemics Patients SARS-CoV-2 Severity of Illness Index Therapy Viral infections Vitamin B Vitamin B 12 - therapeutic use Vitamin B12 Vitamin D Vitamin D - therapeutic use Vitamin D3 Vitamins - therapeutic use |
| title | Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B 12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A32%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cohort%20study%20to%20evaluate%20the%20effect%20of%20vitamin%20D,%20magnesium,%20and%20vitamin%20B%2012%20in%20combination%20on%20progression%20to%20severe%20outcomes%20in%20older%20patients%20with%20coronavirus%20(COVID-19)&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Tan,%20Chuen%20Wen&rft.date=2020-11&rft.volume=79-80&rft.spage=111017&rft.pages=111017-&rft.issn=0899-9007&rft.eissn=1873-1244&rft_id=info:doi/10.1016/j.nut.2020.111017&rft_dat=%3Cproquest_pubme%3E2457592724%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2457592724&rft_id=info:pmid/33039952&rfr_iscdi=true |