Silymarin administration during pregnancy and breastfeeding: evaluation of initial development and adult behavior of mice

•Silymarin treatment has no effect on the course of pregnancy.•The treatment has no effect on the somatic development of the pups.•Maternal treatment has no effect on the cognition of adult pups.•Long-term treatment with silymarin not produced any significant effect on offspring. Silymarin is a phyt...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2020-05, Vol.78, p.64-70
Hauptverfasser:	Barbosa, Caio Cesar, Nishimura, Akemy Nogueira, Santos, Monaliza Lopes dos, Junior, Walter Dias, Andersen, Monica Levy, Mazaro-Costa, Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Behavior, Animal - drug effects Body mass Body Weight - drug effects Breast feeding Breastfeeding & lactation Development Euthanasia Female Genetic crosses Gestation Lactation Male Maternal Behavior - drug effects Mice Offspring Phytotherapic safety Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - psychology Reproductive toxicology Sensory evaluation Sensory-Motor Silybummarianum Silymarin Silymarin - toxicity Vegetable oils
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