Potent cyclometallated Pd() antitumor complexes bearing α-amino acids: synthesis, structural characterization, DNA/BSA binding, cytotoxicity and molecular dynamics simulation

A rational approach was adopted to design high-potential metal-based antitumor agents. A series of organometallic Pd( ii ) complexes with a general formula of [Pd{κ 2 (C,C)-[(C 6 H 4 -2)PPh 2 ]CH(CO)C 6 H 4 Ph-4}{κ 2 (N,O)}] (N,O = alanine ( Pd-A ), valine ( Pd-V ), leucine ( Pd-L ), l -isoleucine (...

Ausführliche Beschreibung