In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts
Background. Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine....
Gespeichert in:
| Veröffentlicht in: | PeerJ (San Francisco, CA) CA), 2020-11, Vol.8, p.e10070-e10070, Article 10070 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e10070 |
|---|---|
| container_issue | |
| container_start_page | e10070 |
| container_title | PeerJ (San Francisco, CA) |
| container_volume | 8 |
| creator | Wariyapperuma, W. A. Niroshani M. Kannangara, Sagarika Wijayasinghe, Yasanandana S. Subramanium, Sri Jayawardena, Bimali |
| description | Background. Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. alpha-amylase and alpha-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC).
Methods. Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), alpha-amylase and alpha-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The alpha-amylase and alpha-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique.
Results and Discussion. Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts.
Conclusions. This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes. |
| doi_str_mv | 10.7717/peerj.10070 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2456626388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A640276223</galeid><doaj_id>oai_doaj_org_article_73dbbb0d87144331b12a19c21f1cc4ec</doaj_id><sourcerecordid>A640276223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-a22d9bb79dd01d6f11469921256766b166361cc1b682050574b0ccc1ac3de1fb3</originalsourceid><addsrcrecordid>eNqNksuP0zAQxiMEYlfLnrijSEhoEWrxI7GTy0qrisdKK3GBs-XHpHWV2MV2Cstfj9Mu3RZxID7EGf_mi-ebKYqXGM05x_z9BiCs5xghjp4U5wQzPmto3T492p8VlzGuUX4awlBDnxdnlOK2orw9L9KtK7c2BV9Kl-zMWKkgWV1C14FOMUdNuVndJ69XMFgt-3ITfGd765al70rnt9CXWxlszoI4hRbWOTn4YRzKX3DfS2d13l7dzd-W8DMFmVVfFM862Ue4fHhfFN8-fvi6-Dy7-_LpdnFzN9M1p2kmCTGtUrw1BmHDOowr1rYEk5pxxhRmjDKsNVasIahGNa8U0vlbamoAd4peFLd7XePlWmyCHWS4F15asQv4sBQy5Gp7EJwapRQyDcdVle1RmEjcaoK7_IcKdNa63mttRjWA0eByLf2J6OmJsyux9FvBWUXrGmWBqweB4L-PEJMYbNTQZ4fAj1GQiu3a2JKMvv4LXfsxuGxVpmrGCKNN80gtZS7Aus5P7k6i4oZViHBGCM3U_B9UXmbqp3eQmwmnCW-OElYg-7SKvh-T9S6egu_2oA4-xgDdwQyMxDScYjecYldVpl8d-3dg_4xiBpo98AOU76K24DQcsDy9dUMZxXQaZLKwSU4XWvjRpceb_E8q_Q1_Of8P</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2456626388</pqid></control><display><type>article</type><title>In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>PubMed Central</source><creator>Wariyapperuma, W. A. Niroshani M. ; Kannangara, Sagarika ; Wijayasinghe, Yasanandana S. ; Subramanium, Sri ; Jayawardena, Bimali</creator><creatorcontrib>Wariyapperuma, W. A. Niroshani M. ; Kannangara, Sagarika ; Wijayasinghe, Yasanandana S. ; Subramanium, Sri ; Jayawardena, Bimali</creatorcontrib><description>Background. Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. alpha-amylase and alpha-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC).
Methods. Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), alpha-amylase and alpha-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The alpha-amylase and alpha-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique.
Results and Discussion. Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts.
Conclusions. This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.</description><identifier>ISSN: 2167-8359</identifier><identifier>EISSN: 2167-8359</identifier><identifier>DOI: 10.7717/peerj.10070</identifier><identifier>PMID: 33194379</identifier><language>eng</language><publisher>LONDON: Peerj Inc</publisher><subject>Alcohols ; Amylases ; Analysis ; Benzoic acid ; Benzyl alcohol ; Biochemistry ; Carbohydrates ; Cinnamomum zeylanicum ; Cinnamon ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes mellitus type 2 ; Enzymes ; Food Science and Technology ; Herbal medicine ; Medicinal plants ; Metabolic disorders ; Metabolites ; Multidisciplinary Sciences ; Oxidative stress ; Pharmacology ; Phenolic compounds ; Phytochemicals ; Plant Science ; Pressurized Water Extraction ; Science & Technology ; Science & Technology - Other Topics ; Sri Wijaya ; Steam ; Vanillin ; α-Amylase ; α-Glucosidase</subject><ispartof>PeerJ (San Francisco, CA), 2020-11, Vol.8, p.e10070-e10070, Article 10070</ispartof><rights>2020 Wariyapperuma et al.</rights><rights>COPYRIGHT 2020 PeerJ. Ltd.</rights><rights>2020 Wariyapperuma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Wariyapperuma et al. 2020 Wariyapperuma et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000583631300002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c573t-a22d9bb79dd01d6f11469921256766b166361cc1b682050574b0ccc1ac3de1fb3</citedby><cites>FETCH-LOGICAL-c573t-a22d9bb79dd01d6f11469921256766b166361cc1b682050574b0ccc1ac3de1fb3</cites><orcidid>0000-0002-1269-6397</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643550/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643550/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2118,27933,27934,28257,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33194379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wariyapperuma, W. A. Niroshani M.</creatorcontrib><creatorcontrib>Kannangara, Sagarika</creatorcontrib><creatorcontrib>Wijayasinghe, Yasanandana S.</creatorcontrib><creatorcontrib>Subramanium, Sri</creatorcontrib><creatorcontrib>Jayawardena, Bimali</creatorcontrib><title>In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts</title><title>PeerJ (San Francisco, CA)</title><addtitle>PEERJ</addtitle><addtitle>PeerJ</addtitle><description>Background. Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. alpha-amylase and alpha-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC).
Methods. Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), alpha-amylase and alpha-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The alpha-amylase and alpha-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique.
Results and Discussion. Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts.
Conclusions. This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.</description><subject>Alcohols</subject><subject>Amylases</subject><subject>Analysis</subject><subject>Benzoic acid</subject><subject>Benzyl alcohol</subject><subject>Biochemistry</subject><subject>Carbohydrates</subject><subject>Cinnamomum zeylanicum</subject><subject>Cinnamon</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes mellitus type 2</subject><subject>Enzymes</subject><subject>Food Science and Technology</subject><subject>Herbal medicine</subject><subject>Medicinal plants</subject><subject>Metabolic disorders</subject><subject>Metabolites</subject><subject>Multidisciplinary Sciences</subject><subject>Oxidative stress</subject><subject>Pharmacology</subject><subject>Phenolic compounds</subject><subject>Phytochemicals</subject><subject>Plant Science</subject><subject>Pressurized Water Extraction</subject><subject>Science & Technology</subject><subject>Science & Technology - Other Topics</subject><subject>Sri Wijaya</subject><subject>Steam</subject><subject>Vanillin</subject><subject>α-Amylase</subject><subject>α-Glucosidase</subject><issn>2167-8359</issn><issn>2167-8359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNksuP0zAQxiMEYlfLnrijSEhoEWrxI7GTy0qrisdKK3GBs-XHpHWV2MV2Cstfj9Mu3RZxID7EGf_mi-ebKYqXGM05x_z9BiCs5xghjp4U5wQzPmto3T492p8VlzGuUX4awlBDnxdnlOK2orw9L9KtK7c2BV9Kl-zMWKkgWV1C14FOMUdNuVndJ69XMFgt-3ITfGd765al70rnt9CXWxlszoI4hRbWOTn4YRzKX3DfS2d13l7dzd-W8DMFmVVfFM862Ue4fHhfFN8-fvi6-Dy7-_LpdnFzN9M1p2kmCTGtUrw1BmHDOowr1rYEk5pxxhRmjDKsNVasIahGNa8U0vlbamoAd4peFLd7XePlWmyCHWS4F15asQv4sBQy5Gp7EJwapRQyDcdVle1RmEjcaoK7_IcKdNa63mttRjWA0eByLf2J6OmJsyux9FvBWUXrGmWBqweB4L-PEJMYbNTQZ4fAj1GQiu3a2JKMvv4LXfsxuGxVpmrGCKNN80gtZS7Aus5P7k6i4oZViHBGCM3U_B9UXmbqp3eQmwmnCW-OElYg-7SKvh-T9S6egu_2oA4-xgDdwQyMxDScYjecYldVpl8d-3dg_4xiBpo98AOU76K24DQcsDy9dUMZxXQaZLKwSU4XWvjRpceb_E8q_Q1_Of8P</recordid><startdate>20201102</startdate><enddate>20201102</enddate><creator>Wariyapperuma, W. A. Niroshani M.</creator><creator>Kannangara, Sagarika</creator><creator>Wijayasinghe, Yasanandana S.</creator><creator>Subramanium, Sri</creator><creator>Jayawardena, Bimali</creator><general>Peerj Inc</general><general>PeerJ. Ltd</general><general>PeerJ, Inc</general><general>PeerJ Inc</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1269-6397</orcidid></search><sort><creationdate>20201102</creationdate><title>In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts</title><author>Wariyapperuma, W. A. Niroshani M. ; Kannangara, Sagarika ; Wijayasinghe, Yasanandana S. ; Subramanium, Sri ; Jayawardena, Bimali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-a22d9bb79dd01d6f11469921256766b166361cc1b682050574b0ccc1ac3de1fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alcohols</topic><topic>Amylases</topic><topic>Analysis</topic><topic>Benzoic acid</topic><topic>Benzyl alcohol</topic><topic>Biochemistry</topic><topic>Carbohydrates</topic><topic>Cinnamomum zeylanicum</topic><topic>Cinnamon</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes mellitus type 2</topic><topic>Enzymes</topic><topic>Food Science and Technology</topic><topic>Herbal medicine</topic><topic>Medicinal plants</topic><topic>Metabolic disorders</topic><topic>Metabolites</topic><topic>Multidisciplinary Sciences</topic><topic>Oxidative stress</topic><topic>Pharmacology</topic><topic>Phenolic compounds</topic><topic>Phytochemicals</topic><topic>Plant Science</topic><topic>Pressurized Water Extraction</topic><topic>Science & Technology</topic><topic>Science & Technology - Other Topics</topic><topic>Sri Wijaya</topic><topic>Steam</topic><topic>Vanillin</topic><topic>α-Amylase</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wariyapperuma, W. A. Niroshani M.</creatorcontrib><creatorcontrib>Kannangara, Sagarika</creatorcontrib><creatorcontrib>Wijayasinghe, Yasanandana S.</creatorcontrib><creatorcontrib>Subramanium, Sri</creatorcontrib><creatorcontrib>Jayawardena, Bimali</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PeerJ (San Francisco, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wariyapperuma, W. A. Niroshani M.</au><au>Kannangara, Sagarika</au><au>Wijayasinghe, Yasanandana S.</au><au>Subramanium, Sri</au><au>Jayawardena, Bimali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts</atitle><jtitle>PeerJ (San Francisco, CA)</jtitle><stitle>PEERJ</stitle><addtitle>PeerJ</addtitle><date>2020-11-02</date><risdate>2020</risdate><volume>8</volume><spage>e10070</spage><epage>e10070</epage><pages>e10070-e10070</pages><artnum>10070</artnum><artnum>e10070</artnum><issn>2167-8359</issn><eissn>2167-8359</eissn><abstract>Background. Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. alpha-amylase and alpha-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC).
Methods. Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), alpha-amylase and alpha-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The alpha-amylase and alpha-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique.
Results and Discussion. Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts.
Conclusions. This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.</abstract><cop>LONDON</cop><pub>Peerj Inc</pub><pmid>33194379</pmid><doi>10.7717/peerj.10070</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-1269-6397</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2167-8359 |
| ispartof | PeerJ (San Francisco, CA), 2020-11, Vol.8, p.e10070-e10070, Article 10070 |
| issn | 2167-8359 2167-8359 |
| language | eng |
| recordid | cdi_proquest_journals_2456626388 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; PubMed Central |
| subjects | Alcohols Amylases Analysis Benzoic acid Benzyl alcohol Biochemistry Carbohydrates Cinnamomum zeylanicum Cinnamon Diabetes Diabetes mellitus (non-insulin dependent) Diabetes mellitus type 2 Enzymes Food Science and Technology Herbal medicine Medicinal plants Metabolic disorders Metabolites Multidisciplinary Sciences Oxidative stress Pharmacology Phenolic compounds Phytochemicals Plant Science Pressurized Water Extraction Science & Technology Science & Technology - Other Topics Sri Wijaya Steam Vanillin α-Amylase α-Glucosidase |
| title | In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T20%3A52%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vitro%20anti-diabetic%20effects%20and%20phytochemical%20profiling%20of%20novel%20varieties%20of%20Cinnamomum%20zeylanicum%20(L.)%20extracts&rft.jtitle=PeerJ%20(San%20Francisco,%20CA)&rft.au=Wariyapperuma,%20W.%20A.%20Niroshani%20M.&rft.date=2020-11-02&rft.volume=8&rft.spage=e10070&rft.epage=e10070&rft.pages=e10070-e10070&rft.artnum=10070&rft.issn=2167-8359&rft.eissn=2167-8359&rft_id=info:doi/10.7717/peerj.10070&rft_dat=%3Cgale_proqu%3EA640276223%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2456626388&rft_id=info:pmid/33194379&rft_galeid=A640276223&rft_doaj_id=oai_doaj_org_article_73dbbb0d87144331b12a19c21f1cc4ec&rfr_iscdi=true |