Comparison of methods of synthesis of 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in supercritical carbon dioxide
For the optimization of the method of synthesizing 5-methyl-1,2,4-triazolo[1,5-a]pyrimidine-7(4H)-one (an intermediate of the antiviral drug Triazid®) by cyclocondensation of 5-amino-3-H-1,2,4-triazole (aminotriazole) with acetoacetic ester, various conditions (reaction in supercritical carbon dioxi...
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| creator | Baklykov, Artem V. Rusinov, Gennady L. Zyryanov, Grigory V. Kopchuk, Dmitry S. Charushin, Valery N. Artem'ev, Grigory A. Rusinov, Vladimir L. Khasanov, Albert F. |
| description | For the optimization of the method of synthesizing 5-methyl-1,2,4-triazolo[1,5-a]pyrimidine-7(4H)-one (an intermediate of the antiviral drug Triazid®) by cyclocondensation of 5-amino-3-H-1,2,4-triazole (aminotriazole) with acetoacetic ester, various conditions (reaction in supercritical carbon dioxide in the presence of acetic acid, organic solvents, as well as Lewis acid (ZnCl2, TiO2, and SiO2) or inorganic additives) for this reaction were studied. By comparison of the yields of the reaction products, it was concluded that the most preferable conditions are pure supercritical CO2 in the presence of acetic acid or ZnCl2 at a temperature of 150-190 °C. |
| doi_str_mv | 10.1063/5.0018786 |
| format | Conference Proceeding |
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By comparison of the yields of the reaction products, it was concluded that the most preferable conditions are pure supercritical CO2 in the presence of acetic acid or ZnCl2 at a temperature of 150-190 °C.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0018786</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Acetic acid ; Additives ; Carbon dioxide ; Lewis acid ; Optimization ; Reaction products ; Silicon dioxide ; Titanium dioxide ; Triazoles ; Zinc chloride</subject><ispartof>AIP conference proceedings, 2020, Vol.2280 (1)</ispartof><rights>Author(s)</rights><rights>2020 Author(s). 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By comparison of the yields of the reaction products, it was concluded that the most preferable conditions are pure supercritical CO2 in the presence of acetic acid or ZnCl2 at a temperature of 150-190 °C.</description><subject>Acetic acid</subject><subject>Additives</subject><subject>Carbon dioxide</subject><subject>Lewis acid</subject><subject>Optimization</subject><subject>Reaction products</subject><subject>Silicon dioxide</subject><subject>Titanium dioxide</subject><subject>Triazoles</subject><subject>Zinc chloride</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2020</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNp9kEFLAzEQhYMoWKsH_8GCF5WmJtkkmz1KUSsUvCgIIiGbTWjKdrMmqbr-erda8OZpZt58zGMeAKcYTTHi-RWbIoRFIfgeGGHGMCw45vtghFBJIaH58yE4inGFECmLQozAx8yvOxVc9G3mbbY2aenruG1j36alie5nYHC76RuIJ2RCYQpOffnGv-AJg-q164Nbu9q1sDin8wvoW5O5NoubzgQdXHJaNZlWoRpMauc_XW2OwYFVTTQnuzoGT7c3j7M5XDzc3c-uF7DDIk-wVLgUBAkirK0N1kTnWGNCa2a4qlSBlSnzyhrCyCAwzq1mmFSVLRCqbCXyMTj7vdsF_7YxMcmV34R2sJSEMsaJKCkdqMtfKmqXVHK-ld3wkgq9xEhug5VM7oL9D3734Q-UXW3zb8kMeXA</recordid><startdate>20201104</startdate><enddate>20201104</enddate><creator>Baklykov, Artem V.</creator><creator>Rusinov, Gennady L.</creator><creator>Zyryanov, Grigory V.</creator><creator>Kopchuk, Dmitry S.</creator><creator>Charushin, Valery N.</creator><creator>Artem'ev, Grigory A.</creator><creator>Rusinov, Vladimir L.</creator><creator>Khasanov, Albert F.</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20201104</creationdate><title>Comparison of methods of synthesis of 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in supercritical carbon dioxide</title><author>Baklykov, Artem V. ; Rusinov, Gennady L. ; Zyryanov, Grigory V. ; Kopchuk, Dmitry S. ; Charushin, Valery N. ; Artem'ev, Grigory A. ; Rusinov, Vladimir L. ; Khasanov, Albert F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p183t-9a19820828ffde1c2c31c124d5e6aba71ae93bfe252e6a566fc512bbf700bfb83</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Additives</topic><topic>Carbon dioxide</topic><topic>Lewis acid</topic><topic>Optimization</topic><topic>Reaction products</topic><topic>Silicon dioxide</topic><topic>Titanium dioxide</topic><topic>Triazoles</topic><topic>Zinc chloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baklykov, Artem V.</creatorcontrib><creatorcontrib>Rusinov, Gennady L.</creatorcontrib><creatorcontrib>Zyryanov, Grigory V.</creatorcontrib><creatorcontrib>Kopchuk, Dmitry S.</creatorcontrib><creatorcontrib>Charushin, Valery N.</creatorcontrib><creatorcontrib>Artem'ev, Grigory A.</creatorcontrib><creatorcontrib>Rusinov, Vladimir L.</creatorcontrib><creatorcontrib>Khasanov, Albert F.</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baklykov, Artem V.</au><au>Rusinov, Gennady L.</au><au>Zyryanov, Grigory V.</au><au>Kopchuk, Dmitry S.</au><au>Charushin, Valery N.</au><au>Artem'ev, Grigory A.</au><au>Rusinov, Vladimir L.</au><au>Khasanov, Albert F.</au><au>Zyryanov, Grigory V</au><au>Santra, Sougata</au><au>Sadieva, Leila K</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Comparison of methods of synthesis of 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in supercritical carbon dioxide</atitle><btitle>AIP conference proceedings</btitle><date>2020-11-04</date><risdate>2020</risdate><volume>2280</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>For the optimization of the method of synthesizing 5-methyl-1,2,4-triazolo[1,5-a]pyrimidine-7(4H)-one (an intermediate of the antiviral drug Triazid®) by cyclocondensation of 5-amino-3-H-1,2,4-triazole (aminotriazole) with acetoacetic ester, various conditions (reaction in supercritical carbon dioxide in the presence of acetic acid, organic solvents, as well as Lewis acid (ZnCl2, TiO2, and SiO2) or inorganic additives) for this reaction were studied. By comparison of the yields of the reaction products, it was concluded that the most preferable conditions are pure supercritical CO2 in the presence of acetic acid or ZnCl2 at a temperature of 150-190 °C.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0018786</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2020, Vol.2280 (1) |
| issn | 0094-243X 1551-7616 |
| language | eng |
| recordid | cdi_proquest_journals_2455628944 |
| source | AIP Journals Complete |
| subjects | Acetic acid Additives Carbon dioxide Lewis acid Optimization Reaction products Silicon dioxide Titanium dioxide Triazoles Zinc chloride |
| title | Comparison of methods of synthesis of 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one in supercritical carbon dioxide |
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