Simultaneous determination of novel ketolide antibiotic nafithromycin and its major metabolite in human plasma using liquid chromatography tandem mass spectrometry

A sensitive method to quantify nafithromycin and its N-desmethyl metabolite in human plasma was necessary for Phase I pharmacokinetic studies. A precise and accurate LC–MS/MS bioanalytical method has been developed and validated for the simultaneous quantification of nafithromycin (NFT, WCK 4873) an...

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Veröffentlicht in:	Bioanalysis 2019-10, Vol.11 (19), p.1767-1776
Hauptverfasser:	Patil, Kiran R, Yeole, Ravindra D, Zwart, Marcel de, Pruim, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Anti-Bacterial Agents - blood Anti-Bacterial Agents - metabolism Antibiotics bioanalysis Calibration Chromatography Chromatography, High Pressure Liquid - methods Clarithromycin Drug Monitoring - methods Humans Ketolides - blood Ketolides - metabolism Lactones - blood Lactones - metabolism Liquid chromatography mass spectrometry Mass spectroscopy Metabolites N-desmethyl metabolite nafithromycin Pharmacokinetics Plasma Plasma levels Quality control Quality standards Reproducibility of Results Solvents Tandem Mass Spectrometry - methods
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