BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates
•BICC1 was overexpressed in gastric cancer.•High expression of BICC1 was correlated with poor prognosis in gastric cancer.•BICC1 was positively associated with tumor-infiltrating immune cells.•BICC1 was correlated with multiple tumor/immune signaling pathways. BicC family RNA-binding protein 1 (BICC...
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| Veröffentlicht in: | International immunopharmacology 2020-10, Vol.87, p.106828, Article 106828 |
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| creator | Zhao, Rulin Peng, Chao Song, Conghua Zhao, Qiaoyun Rong, Jianfang Wang, Huan Ding, Wenjie Wang, Fangfei Xie, Yong |
| description | •BICC1 was overexpressed in gastric cancer.•High expression of BICC1 was correlated with poor prognosis in gastric cancer.•BICC1 was positively associated with tumor-infiltrating immune cells.•BICC1 was correlated with multiple tumor/immune signaling pathways.
BicC family RNA-binding protein 1 (BICC1) codes an RNA-binding protein that regulates gene expression and modulates cell proliferation and apoptosis. We aim at investigating the role of BICC1 in gastric carcinogenesis.
BICC1 mRNA expression in gastric cancer (GC) was examined using the Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Correlations between BICC1 expression and clinicopathological parameters were analyzed. The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter databases were used to examine the clinical prognostic significance of BICC1 in GC. Signaling pathways related to BICC1 expression were identified by gene set enrichment analysis (GSEA).
TIMER and CIBERSORT were used to analyze the correlations among BICC1, BICC1-coexpressed genes and tumor-infiltrating immune cells.
BICC1 was highly expressed in GC and significantly correlated with grade (P = 0.002), TNM stage (P = 0.033), invasion depth (P = 0.001) and vital status (P = 0.009) of GC patients. High BICC1 expression correlated with poor overall survival. The GSEA results showed that cell adhesion-, tumor- and immune- related pathways were significantly enriched in samples with high BICC1 expression. BICC1 and its coexpressed genes were positively related to tumor-infiltrating immune cells and were strongly correlated with tumor-infiltrating macrophages (all r ≥ 0.582, P |
| doi_str_mv | 10.1016/j.intimp.2020.106828 |
| format | Article |
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BicC family RNA-binding protein 1 (BICC1) codes an RNA-binding protein that regulates gene expression and modulates cell proliferation and apoptosis. We aim at investigating the role of BICC1 in gastric carcinogenesis.
BICC1 mRNA expression in gastric cancer (GC) was examined using the Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Correlations between BICC1 expression and clinicopathological parameters were analyzed. The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter databases were used to examine the clinical prognostic significance of BICC1 in GC. Signaling pathways related to BICC1 expression were identified by gene set enrichment analysis (GSEA).
TIMER and CIBERSORT were used to analyze the correlations among BICC1, BICC1-coexpressed genes and tumor-infiltrating immune cells.
BICC1 was highly expressed in GC and significantly correlated with grade (P = 0.002), TNM stage (P = 0.033), invasion depth (P = 0.001) and vital status (P = 0.009) of GC patients. High BICC1 expression correlated with poor overall survival. The GSEA results showed that cell adhesion-, tumor- and immune- related pathways were significantly enriched in samples with high BICC1 expression. BICC1 and its coexpressed genes were positively related to tumor-infiltrating immune cells and were strongly correlated with tumor-infiltrating macrophages (all r ≥ 0.582, P < 0.0001). The CIBERSORT database revealed that BICC1 correlated with M2 macrophages (P < 0.0001), regulatory T cells (P < 0.0001), resting mast cells (P < 0.0001), activated memory CD4+ T cells (P = 0.002), resting NK cells (P = 0.002), activated dendritic cells (P = 0.002), and follicular helper T cells (P = 0.016). The results from TIMER database confirmed that BICC1 is closely associated with the markers of M2 macrophages and tumor-associated macrophages (all r ≥ 0.5, P < 0.0001).
BICC1 may be a potential prognostic biomarker in GC and correlates with immune infiltrates.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.106828</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Apoptosis ; BICC1 ; Biomarkers ; Cancer ; Carcinogenesis ; Carcinogens ; CD4 antigen ; Cell adhesion ; Cell adhesion & migration ; Cell proliferation ; Correlation analysis ; Dendritic cells ; Gastric cancer ; Gene expression ; Gene set enrichment analysis ; Genes ; Genomes ; Immune infiltrates ; Immune system ; Immunological memory ; Immunoregulation ; Lymphocytes ; Lymphocytes T ; Macrophages ; Mast cells ; Memory cells ; Prognosis ; Proteins ; Ribonucleic acid ; RNA ; RNA-binding protein ; Tumor-associated macrophage ; Tumor-infiltrating lymphocytes ; Tumors</subject><ispartof>International immunopharmacology, 2020-10, Vol.87, p.106828, Article 106828</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright Elsevier BV Oct 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-deea41f38b75d76be1747d15482aff55bb8b95a9ce0ef0dd57fe0ef2e2d0bae3</citedby><cites>FETCH-LOGICAL-c367t-deea41f38b75d76be1747d15482aff55bb8b95a9ce0ef0dd57fe0ef2e2d0bae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.106828$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids></links><search><creatorcontrib>Zhao, Rulin</creatorcontrib><creatorcontrib>Peng, Chao</creatorcontrib><creatorcontrib>Song, Conghua</creatorcontrib><creatorcontrib>Zhao, Qiaoyun</creatorcontrib><creatorcontrib>Rong, Jianfang</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Ding, Wenjie</creatorcontrib><creatorcontrib>Wang, Fangfei</creatorcontrib><creatorcontrib>Xie, Yong</creatorcontrib><title>BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates</title><title>International immunopharmacology</title><description>•BICC1 was overexpressed in gastric cancer.•High expression of BICC1 was correlated with poor prognosis in gastric cancer.•BICC1 was positively associated with tumor-infiltrating immune cells.•BICC1 was correlated with multiple tumor/immune signaling pathways.
BicC family RNA-binding protein 1 (BICC1) codes an RNA-binding protein that regulates gene expression and modulates cell proliferation and apoptosis. We aim at investigating the role of BICC1 in gastric carcinogenesis.
BICC1 mRNA expression in gastric cancer (GC) was examined using the Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Correlations between BICC1 expression and clinicopathological parameters were analyzed. The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter databases were used to examine the clinical prognostic significance of BICC1 in GC. Signaling pathways related to BICC1 expression were identified by gene set enrichment analysis (GSEA).
TIMER and CIBERSORT were used to analyze the correlations among BICC1, BICC1-coexpressed genes and tumor-infiltrating immune cells.
BICC1 was highly expressed in GC and significantly correlated with grade (P = 0.002), TNM stage (P = 0.033), invasion depth (P = 0.001) and vital status (P = 0.009) of GC patients. High BICC1 expression correlated with poor overall survival. The GSEA results showed that cell adhesion-, tumor- and immune- related pathways were significantly enriched in samples with high BICC1 expression. BICC1 and its coexpressed genes were positively related to tumor-infiltrating immune cells and were strongly correlated with tumor-infiltrating macrophages (all r ≥ 0.582, P < 0.0001). The CIBERSORT database revealed that BICC1 correlated with M2 macrophages (P < 0.0001), regulatory T cells (P < 0.0001), resting mast cells (P < 0.0001), activated memory CD4+ T cells (P = 0.002), resting NK cells (P = 0.002), activated dendritic cells (P = 0.002), and follicular helper T cells (P = 0.016). The results from TIMER database confirmed that BICC1 is closely associated with the markers of M2 macrophages and tumor-associated macrophages (all r ≥ 0.5, P < 0.0001).
BICC1 may be a potential prognostic biomarker in GC and correlates with immune infiltrates.</description><subject>Apoptosis</subject><subject>BICC1</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>CD4 antigen</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell proliferation</subject><subject>Correlation analysis</subject><subject>Dendritic cells</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene set enrichment analysis</subject><subject>Genes</subject><subject>Genomes</subject><subject>Immune infiltrates</subject><subject>Immune system</subject><subject>Immunological memory</subject><subject>Immunoregulation</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Mast cells</subject><subject>Memory cells</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA-binding protein</subject><subject>Tumor-associated macrophage</subject><subject>Tumor-infiltrating lymphocytes</subject><subject>Tumors</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EEqXwDxgsMafYbhynCxJEPCpVYunGYDn2dXFo4mK7IP49jsLMdI-Ozn19CF1TsqCEVrfdwg3J9YcFI2y0qprVJ2hGa1EXVBB-mjWvRMFFtTpHFzF2hGS_pDP09rBuGopVxAoP_gv2-BD8bvAxOY1b53sVPiBgN-CdiilkU6tBZ0f7EGCvkht2-Nuld-z6_jhATlq3T0EliJfozKp9hKu_Okfbp8dt81JsXp_Xzf2m0MtKpMIAqJLaZd0KbkTVAhWlMJSXNVPWct62dbviaqWBgCXGcGFHxYAZ0ipYztHNNDZf_nmEmGTnj2HIGyUreckpYbzKqXJK6eBjDGDlIbj83Y-kRI4UZScninKkKCeKue1uaoP8wJeDIKN2kAkYF0Anabz7f8Avseh-2A</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Zhao, Rulin</creator><creator>Peng, Chao</creator><creator>Song, Conghua</creator><creator>Zhao, Qiaoyun</creator><creator>Rong, Jianfang</creator><creator>Wang, Huan</creator><creator>Ding, Wenjie</creator><creator>Wang, Fangfei</creator><creator>Xie, Yong</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>202010</creationdate><title>BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates</title><author>Zhao, Rulin ; Peng, Chao ; Song, Conghua ; Zhao, Qiaoyun ; Rong, Jianfang ; Wang, Huan ; Ding, Wenjie ; Wang, Fangfei ; Xie, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-deea41f38b75d76be1747d15482aff55bb8b95a9ce0ef0dd57fe0ef2e2d0bae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>BICC1</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>CD4 antigen</topic><topic>Cell adhesion</topic><topic>Cell adhesion & migration</topic><topic>Cell proliferation</topic><topic>Correlation analysis</topic><topic>Dendritic cells</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Gene set enrichment analysis</topic><topic>Genes</topic><topic>Genomes</topic><topic>Immune infiltrates</topic><topic>Immune system</topic><topic>Immunological memory</topic><topic>Immunoregulation</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Mast cells</topic><topic>Memory cells</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA-binding protein</topic><topic>Tumor-associated macrophage</topic><topic>Tumor-infiltrating lymphocytes</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Rulin</creatorcontrib><creatorcontrib>Peng, Chao</creatorcontrib><creatorcontrib>Song, Conghua</creatorcontrib><creatorcontrib>Zhao, Qiaoyun</creatorcontrib><creatorcontrib>Rong, Jianfang</creatorcontrib><creatorcontrib>Wang, Huan</creatorcontrib><creatorcontrib>Ding, Wenjie</creatorcontrib><creatorcontrib>Wang, Fangfei</creatorcontrib><creatorcontrib>Xie, Yong</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Rulin</au><au>Peng, Chao</au><au>Song, Conghua</au><au>Zhao, Qiaoyun</au><au>Rong, Jianfang</au><au>Wang, Huan</au><au>Ding, Wenjie</au><au>Wang, Fangfei</au><au>Xie, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates</atitle><jtitle>International immunopharmacology</jtitle><date>2020-10</date><risdate>2020</risdate><volume>87</volume><spage>106828</spage><pages>106828-</pages><artnum>106828</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>•BICC1 was overexpressed in gastric cancer.•High expression of BICC1 was correlated with poor prognosis in gastric cancer.•BICC1 was positively associated with tumor-infiltrating immune cells.•BICC1 was correlated with multiple tumor/immune signaling pathways.
BicC family RNA-binding protein 1 (BICC1) codes an RNA-binding protein that regulates gene expression and modulates cell proliferation and apoptosis. We aim at investigating the role of BICC1 in gastric carcinogenesis.
BICC1 mRNA expression in gastric cancer (GC) was examined using the Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Correlations between BICC1 expression and clinicopathological parameters were analyzed. The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter databases were used to examine the clinical prognostic significance of BICC1 in GC. Signaling pathways related to BICC1 expression were identified by gene set enrichment analysis (GSEA).
TIMER and CIBERSORT were used to analyze the correlations among BICC1, BICC1-coexpressed genes and tumor-infiltrating immune cells.
BICC1 was highly expressed in GC and significantly correlated with grade (P = 0.002), TNM stage (P = 0.033), invasion depth (P = 0.001) and vital status (P = 0.009) of GC patients. High BICC1 expression correlated with poor overall survival. The GSEA results showed that cell adhesion-, tumor- and immune- related pathways were significantly enriched in samples with high BICC1 expression. BICC1 and its coexpressed genes were positively related to tumor-infiltrating immune cells and were strongly correlated with tumor-infiltrating macrophages (all r ≥ 0.582, P < 0.0001). The CIBERSORT database revealed that BICC1 correlated with M2 macrophages (P < 0.0001), regulatory T cells (P < 0.0001), resting mast cells (P < 0.0001), activated memory CD4+ T cells (P = 0.002), resting NK cells (P = 0.002), activated dendritic cells (P = 0.002), and follicular helper T cells (P = 0.016). The results from TIMER database confirmed that BICC1 is closely associated with the markers of M2 macrophages and tumor-associated macrophages (all r ≥ 0.5, P < 0.0001).
BICC1 may be a potential prognostic biomarker in GC and correlates with immune infiltrates.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.intimp.2020.106828</doi></addata></record> |
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| subjects | Apoptosis BICC1 Biomarkers Cancer Carcinogenesis Carcinogens CD4 antigen Cell adhesion Cell adhesion & migration Cell proliferation Correlation analysis Dendritic cells Gastric cancer Gene expression Gene set enrichment analysis Genes Genomes Immune infiltrates Immune system Immunological memory Immunoregulation Lymphocytes Lymphocytes T Macrophages Mast cells Memory cells Prognosis Proteins Ribonucleic acid RNA RNA-binding protein Tumor-associated macrophage Tumor-infiltrating lymphocytes Tumors |
| title | BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates |
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