Quantification of PD-L1 Expression with 18F-BMS-986192 PET/CT in Patients with Advanced-Stage Non–Small Cell Lung Cancer

The aim of this work was to quantify the uptake of 18F-BMS-986192, a programmed cell death ligand 1 (PD-L1) adnectin PET tracer, in patients with non–small cell lung cancer. To this end, plasma input kinetic modeling of dynamic tumor uptake data with online arterial blood sampling was performed. In...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2020-10, Vol.61 (10), p.1455
Hauptverfasser:	Huisman, Marc C, Niemeijer, Anna-Larissa N, Windhorst, Albert D, Schuit, Robert C, Leung, David, Hayes, Wendy, Poot, Alex, Bahce, Idris, Radonic, Teodora, Oprea-Lager, Daniela E, Hoekstra, Otto S, Thunnissen, Erik, Hendrikse, N Harry, Smit, Egbert F, de Langen, Adrianus J, Boellaard, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Baseline studies Blood Blood volume Body weight Cell death Computed tomography Field of view Fluorine isotopes Immune checkpoint inhibitors Injection Lung cancer Mathematical models Medical imaging Monoclonal antibodies Non-small cell lung carcinoma Parameters PD-L1 protein Plasma Positron emission Sampling Targeted cancer therapy Tomography Tumors
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