Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG
Background In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR). Methods Data from...
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| Veröffentlicht in: | Cancer 2020-11, Vol.126 (22), p.4917-4925 |
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| creator | Houdt, Winan J. Fiore, Marco Barretta, Francesco Rutkowski, Piotr Blay, Jean‐Yves Lahat, Guy Strauss, Dirk Gonzalez, Ricardo J. Ahuja, Nita Grignani, Giovanni Quagliuolo, Vittorio Stoeckle, Eberhard De Paoli, Antonino Schrage, Yvonne Cardona, Kenneth Pennacchioli, Elisabetta Pillarisetty, Venu G. Nessim, Carolyn Swallow, Carol J. Bagaria, Sanjay P. Canter, Robert Mullen, John T. Callegaro, Dario Fairweather, Mark Miceli, Rosalba Raut, Chandrajit P. Gronchi, Alessandro Gladdy, Rebecca A. |
| description | Background
In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR).
Methods
Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence.
Results
Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re‐resection (61.9%). The 5‐year OS rate varied significantly based on the pattern of failure (P |
| doi_str_mv | 10.1002/cncr.33139 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2453671774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2453671774</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-dd913ea1dd73598d96d53f8e8ec536cf39e569dd87fb40c2839b3438402b6d093</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobk5v_AES8E7oTHrapvFuFJ3C0DEnelfSJIVK18ykne7fm30oXnl1OPC8z-G8CJ1TMqSEhNeykXYIQIEfoD4lnAWERuEh6hNC0iCO4K2HTpx79ysLYzhGPQgZZ4xAH31NRdtq2zhsSmy17KzVjdRYNAq7zq6qlajx0ppCFFVdtWssSo9jp6XxxJ_ANt5as9S2ak2jfcwJK81C3OARdm2n1ri0ZoHno9n0-XV8io5KUTt9tp8D9HJ3O8_ug8nT-CEbTQIJHHigFKegBVWKQcxTxRMVQ5nqVMsYElkC13HClUpZWUREhinwAiJIIxIWiSIcBuhy5_VPfHTatfm76WzjT-Zh5BWMMhZ56mpHSWucs7rMl7ZaCLvOKck3JeebkvNtyR6-2Cu7YqHVL_rTqgfoDvisar3-R5Vnj9lsJ_0GRqaIhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2453671774</pqid></control><display><type>article</type><title>Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG</title><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Houdt, Winan J. ; Fiore, Marco ; Barretta, Francesco ; Rutkowski, Piotr ; Blay, Jean‐Yves ; Lahat, Guy ; Strauss, Dirk ; Gonzalez, Ricardo J. ; Ahuja, Nita ; Grignani, Giovanni ; Quagliuolo, Vittorio ; Stoeckle, Eberhard ; De Paoli, Antonino ; Schrage, Yvonne ; Cardona, Kenneth ; Pennacchioli, Elisabetta ; Pillarisetty, Venu G. ; Nessim, Carolyn ; Swallow, Carol J. ; Bagaria, Sanjay P. ; Canter, Robert ; Mullen, John T. ; Callegaro, Dario ; Fairweather, Mark ; Miceli, Rosalba ; Raut, Chandrajit P. ; Gronchi, Alessandro ; Gladdy, Rebecca A.</creator><creatorcontrib>Houdt, Winan J. ; Fiore, Marco ; Barretta, Francesco ; Rutkowski, Piotr ; Blay, Jean‐Yves ; Lahat, Guy ; Strauss, Dirk ; Gonzalez, Ricardo J. ; Ahuja, Nita ; Grignani, Giovanni ; Quagliuolo, Vittorio ; Stoeckle, Eberhard ; De Paoli, Antonino ; Schrage, Yvonne ; Cardona, Kenneth ; Pennacchioli, Elisabetta ; Pillarisetty, Venu G. ; Nessim, Carolyn ; Swallow, Carol J. ; Bagaria, Sanjay P. ; Canter, Robert ; Mullen, John T. ; Callegaro, Dario ; Fairweather, Mark ; Miceli, Rosalba ; Raut, Chandrajit P. ; Gronchi, Alessandro ; Gladdy, Rebecca A.</creatorcontrib><description>Background
In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR).
Methods
Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence.
Results
Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re‐resection (61.9%). The 5‐year OS rate varied significantly based on the pattern of failure (P < .001): 45.6% for the LR group, 25.5% for the DM group, and 0% for the group with LR and DM. The only factors found to be associated with improved OS on multivariable analysis were both time between second surgery and the development of the second recurrence (32 months vs 8 months: hazard ratio, 0.44 [P < .001]) and surgery for second recurrence (yes vs no: hazard ratio, 3.25 [P < .001]). The 5‐year OS rate for patients undergoing surgery for a second LR was 59% versus 18% in the patients not deemed suitable for surgical resection.
Conclusions
Survival rates after second recurrence of RPS varied based on patterns of disease recurrence and treatment. Durable disease‐free survivors were identified after surgery for second LR in patients selected for this intervention.
The current series, derived from 22 sarcoma centers from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) collaborative, describes the outcomes of patients experiencing a second recurrence of retroperitoneal sarcoma. Second recurrences are reported in approximately 70.5% of patients, with a 5‐year overall survival rate of between 0% and 45%, but durable disease‐free survivors are identified after surgery for second local recurrence among selected patients.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.33139</identifier><identifier>PMID: 32797703</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Gastric cancer ; Health hazards ; leiomyosarcoma ; Liposarcoma ; Medical treatment ; Metastases ; Oncology ; Patients ; recurrence ; retroperitoneal sarcoma ; Sarcoma ; Surgery ; Survival</subject><ispartof>Cancer, 2020-11, Vol.126 (22), p.4917-4925</ispartof><rights>2020 American Cancer Society</rights><rights>2020 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-dd913ea1dd73598d96d53f8e8ec536cf39e569dd87fb40c2839b3438402b6d093</citedby><cites>FETCH-LOGICAL-c3939-dd913ea1dd73598d96d53f8e8ec536cf39e569dd87fb40c2839b3438402b6d093</cites><orcidid>0000-0001-8220-424X ; 0000-0002-3392-4002 ; 0000-0001-7190-120X ; 0000-0001-6677-8964 ; 0000-0002-2303-3468 ; 0000-0001-5515-569X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.33139$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.33139$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32797703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houdt, Winan J.</creatorcontrib><creatorcontrib>Fiore, Marco</creatorcontrib><creatorcontrib>Barretta, Francesco</creatorcontrib><creatorcontrib>Rutkowski, Piotr</creatorcontrib><creatorcontrib>Blay, Jean‐Yves</creatorcontrib><creatorcontrib>Lahat, Guy</creatorcontrib><creatorcontrib>Strauss, Dirk</creatorcontrib><creatorcontrib>Gonzalez, Ricardo J.</creatorcontrib><creatorcontrib>Ahuja, Nita</creatorcontrib><creatorcontrib>Grignani, Giovanni</creatorcontrib><creatorcontrib>Quagliuolo, Vittorio</creatorcontrib><creatorcontrib>Stoeckle, Eberhard</creatorcontrib><creatorcontrib>De Paoli, Antonino</creatorcontrib><creatorcontrib>Schrage, Yvonne</creatorcontrib><creatorcontrib>Cardona, Kenneth</creatorcontrib><creatorcontrib>Pennacchioli, Elisabetta</creatorcontrib><creatorcontrib>Pillarisetty, Venu G.</creatorcontrib><creatorcontrib>Nessim, Carolyn</creatorcontrib><creatorcontrib>Swallow, Carol J.</creatorcontrib><creatorcontrib>Bagaria, Sanjay P.</creatorcontrib><creatorcontrib>Canter, Robert</creatorcontrib><creatorcontrib>Mullen, John T.</creatorcontrib><creatorcontrib>Callegaro, Dario</creatorcontrib><creatorcontrib>Fairweather, Mark</creatorcontrib><creatorcontrib>Miceli, Rosalba</creatorcontrib><creatorcontrib>Raut, Chandrajit P.</creatorcontrib><creatorcontrib>Gronchi, Alessandro</creatorcontrib><creatorcontrib>Gladdy, Rebecca A.</creatorcontrib><title>Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR).
Methods
Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence.
Results
Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re‐resection (61.9%). The 5‐year OS rate varied significantly based on the pattern of failure (P < .001): 45.6% for the LR group, 25.5% for the DM group, and 0% for the group with LR and DM. The only factors found to be associated with improved OS on multivariable analysis were both time between second surgery and the development of the second recurrence (32 months vs 8 months: hazard ratio, 0.44 [P < .001]) and surgery for second recurrence (yes vs no: hazard ratio, 3.25 [P < .001]). The 5‐year OS rate for patients undergoing surgery for a second LR was 59% versus 18% in the patients not deemed suitable for surgical resection.
Conclusions
Survival rates after second recurrence of RPS varied based on patterns of disease recurrence and treatment. Durable disease‐free survivors were identified after surgery for second LR in patients selected for this intervention.
The current series, derived from 22 sarcoma centers from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) collaborative, describes the outcomes of patients experiencing a second recurrence of retroperitoneal sarcoma. Second recurrences are reported in approximately 70.5% of patients, with a 5‐year overall survival rate of between 0% and 45%, but durable disease‐free survivors are identified after surgery for second local recurrence among selected patients.</description><subject>Gastric cancer</subject><subject>Health hazards</subject><subject>leiomyosarcoma</subject><subject>Liposarcoma</subject><subject>Medical treatment</subject><subject>Metastases</subject><subject>Oncology</subject><subject>Patients</subject><subject>recurrence</subject><subject>retroperitoneal sarcoma</subject><subject>Sarcoma</subject><subject>Surgery</subject><subject>Survival</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobk5v_AES8E7oTHrapvFuFJ3C0DEnelfSJIVK18ykne7fm30oXnl1OPC8z-G8CJ1TMqSEhNeykXYIQIEfoD4lnAWERuEh6hNC0iCO4K2HTpx79ysLYzhGPQgZZ4xAH31NRdtq2zhsSmy17KzVjdRYNAq7zq6qlajx0ppCFFVdtWssSo9jp6XxxJ_ANt5as9S2ak2jfcwJK81C3OARdm2n1ri0ZoHno9n0-XV8io5KUTt9tp8D9HJ3O8_ug8nT-CEbTQIJHHigFKegBVWKQcxTxRMVQ5nqVMsYElkC13HClUpZWUREhinwAiJIIxIWiSIcBuhy5_VPfHTatfm76WzjT-Zh5BWMMhZ56mpHSWucs7rMl7ZaCLvOKck3JeebkvNtyR6-2Cu7YqHVL_rTqgfoDvisar3-R5Vnj9lsJ_0GRqaIhw</recordid><startdate>20201115</startdate><enddate>20201115</enddate><creator>Houdt, Winan J.</creator><creator>Fiore, Marco</creator><creator>Barretta, Francesco</creator><creator>Rutkowski, Piotr</creator><creator>Blay, Jean‐Yves</creator><creator>Lahat, Guy</creator><creator>Strauss, Dirk</creator><creator>Gonzalez, Ricardo J.</creator><creator>Ahuja, Nita</creator><creator>Grignani, Giovanni</creator><creator>Quagliuolo, Vittorio</creator><creator>Stoeckle, Eberhard</creator><creator>De Paoli, Antonino</creator><creator>Schrage, Yvonne</creator><creator>Cardona, Kenneth</creator><creator>Pennacchioli, Elisabetta</creator><creator>Pillarisetty, Venu G.</creator><creator>Nessim, Carolyn</creator><creator>Swallow, Carol J.</creator><creator>Bagaria, Sanjay P.</creator><creator>Canter, Robert</creator><creator>Mullen, John T.</creator><creator>Callegaro, Dario</creator><creator>Fairweather, Mark</creator><creator>Miceli, Rosalba</creator><creator>Raut, Chandrajit P.</creator><creator>Gronchi, Alessandro</creator><creator>Gladdy, Rebecca A.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0001-8220-424X</orcidid><orcidid>https://orcid.org/0000-0002-3392-4002</orcidid><orcidid>https://orcid.org/0000-0001-7190-120X</orcidid><orcidid>https://orcid.org/0000-0001-6677-8964</orcidid><orcidid>https://orcid.org/0000-0002-2303-3468</orcidid><orcidid>https://orcid.org/0000-0001-5515-569X</orcidid></search><sort><creationdate>20201115</creationdate><title>Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG</title><author>Houdt, Winan J. ; Fiore, Marco ; Barretta, Francesco ; Rutkowski, Piotr ; Blay, Jean‐Yves ; Lahat, Guy ; Strauss, Dirk ; Gonzalez, Ricardo J. ; Ahuja, Nita ; Grignani, Giovanni ; Quagliuolo, Vittorio ; Stoeckle, Eberhard ; De Paoli, Antonino ; Schrage, Yvonne ; Cardona, Kenneth ; Pennacchioli, Elisabetta ; Pillarisetty, Venu G. ; Nessim, Carolyn ; Swallow, Carol J. ; Bagaria, Sanjay P. ; Canter, Robert ; Mullen, John T. ; Callegaro, Dario ; Fairweather, Mark ; Miceli, Rosalba ; Raut, Chandrajit P. ; Gronchi, Alessandro ; Gladdy, Rebecca A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-dd913ea1dd73598d96d53f8e8ec536cf39e569dd87fb40c2839b3438402b6d093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Gastric cancer</topic><topic>Health hazards</topic><topic>leiomyosarcoma</topic><topic>Liposarcoma</topic><topic>Medical treatment</topic><topic>Metastases</topic><topic>Oncology</topic><topic>Patients</topic><topic>recurrence</topic><topic>retroperitoneal sarcoma</topic><topic>Sarcoma</topic><topic>Surgery</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houdt, Winan J.</creatorcontrib><creatorcontrib>Fiore, Marco</creatorcontrib><creatorcontrib>Barretta, Francesco</creatorcontrib><creatorcontrib>Rutkowski, Piotr</creatorcontrib><creatorcontrib>Blay, Jean‐Yves</creatorcontrib><creatorcontrib>Lahat, Guy</creatorcontrib><creatorcontrib>Strauss, Dirk</creatorcontrib><creatorcontrib>Gonzalez, Ricardo J.</creatorcontrib><creatorcontrib>Ahuja, Nita</creatorcontrib><creatorcontrib>Grignani, Giovanni</creatorcontrib><creatorcontrib>Quagliuolo, Vittorio</creatorcontrib><creatorcontrib>Stoeckle, Eberhard</creatorcontrib><creatorcontrib>De Paoli, Antonino</creatorcontrib><creatorcontrib>Schrage, Yvonne</creatorcontrib><creatorcontrib>Cardona, Kenneth</creatorcontrib><creatorcontrib>Pennacchioli, Elisabetta</creatorcontrib><creatorcontrib>Pillarisetty, Venu G.</creatorcontrib><creatorcontrib>Nessim, Carolyn</creatorcontrib><creatorcontrib>Swallow, Carol J.</creatorcontrib><creatorcontrib>Bagaria, Sanjay P.</creatorcontrib><creatorcontrib>Canter, Robert</creatorcontrib><creatorcontrib>Mullen, John T.</creatorcontrib><creatorcontrib>Callegaro, Dario</creatorcontrib><creatorcontrib>Fairweather, Mark</creatorcontrib><creatorcontrib>Miceli, Rosalba</creatorcontrib><creatorcontrib>Raut, Chandrajit P.</creatorcontrib><creatorcontrib>Gronchi, Alessandro</creatorcontrib><creatorcontrib>Gladdy, Rebecca A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houdt, Winan J.</au><au>Fiore, Marco</au><au>Barretta, Francesco</au><au>Rutkowski, Piotr</au><au>Blay, Jean‐Yves</au><au>Lahat, Guy</au><au>Strauss, Dirk</au><au>Gonzalez, Ricardo J.</au><au>Ahuja, Nita</au><au>Grignani, Giovanni</au><au>Quagliuolo, Vittorio</au><au>Stoeckle, Eberhard</au><au>De Paoli, Antonino</au><au>Schrage, Yvonne</au><au>Cardona, Kenneth</au><au>Pennacchioli, Elisabetta</au><au>Pillarisetty, Venu G.</au><au>Nessim, Carolyn</au><au>Swallow, Carol J.</au><au>Bagaria, Sanjay P.</au><au>Canter, Robert</au><au>Mullen, John T.</au><au>Callegaro, Dario</au><au>Fairweather, Mark</au><au>Miceli, Rosalba</au><au>Raut, Chandrajit P.</au><au>Gronchi, Alessandro</au><au>Gladdy, Rebecca A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2020-11-15</date><risdate>2020</risdate><volume>126</volume><issue>22</issue><spage>4917</spage><epage>4925</epage><pages>4917-4925</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
In this series from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), the authors examined longitudinal outcomes of patients with a second recurrence of retroperitoneal sarcoma (RPS) after complete resection of a first local recurrence (LR).
Methods
Data from patients undergoing resection of a first LR from January 2002 to December 2011were collected from 22 sarcoma centers. The primary outcome was overall survival (OS) after second recurrence.
Results
Second recurrences occurred in 400 of 567 patients (70.5%) after an R0/R1 resection of a first locally recurrent RPS. Patterns of disease recurrence were LR in 323 patients (80.75%), distant metastases (DM) in 55 patients (13.75%), and both LR and DM in 22 patients (5.5%). The main subtype among the LR group was liposarcoma (77%), whereas DM mainly were leiomyosarcomas (43.6%). In patients with a second LR only, a total of 200 patients underwent re‐resection (61.9%). The 5‐year OS rate varied significantly based on the pattern of failure (P < .001): 45.6% for the LR group, 25.5% for the DM group, and 0% for the group with LR and DM. The only factors found to be associated with improved OS on multivariable analysis were both time between second surgery and the development of the second recurrence (32 months vs 8 months: hazard ratio, 0.44 [P < .001]) and surgery for second recurrence (yes vs no: hazard ratio, 3.25 [P < .001]). The 5‐year OS rate for patients undergoing surgery for a second LR was 59% versus 18% in the patients not deemed suitable for surgical resection.
Conclusions
Survival rates after second recurrence of RPS varied based on patterns of disease recurrence and treatment. Durable disease‐free survivors were identified after surgery for second LR in patients selected for this intervention.
The current series, derived from 22 sarcoma centers from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) collaborative, describes the outcomes of patients experiencing a second recurrence of retroperitoneal sarcoma. Second recurrences are reported in approximately 70.5% of patients, with a 5‐year overall survival rate of between 0% and 45%, but durable disease‐free survivors are identified after surgery for second local recurrence among selected patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32797703</pmid><doi>10.1002/cncr.33139</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8220-424X</orcidid><orcidid>https://orcid.org/0000-0002-3392-4002</orcidid><orcidid>https://orcid.org/0000-0001-7190-120X</orcidid><orcidid>https://orcid.org/0000-0001-6677-8964</orcidid><orcidid>https://orcid.org/0000-0002-2303-3468</orcidid><orcidid>https://orcid.org/0000-0001-5515-569X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Gastric cancer Health hazards leiomyosarcoma Liposarcoma Medical treatment Metastases Oncology Patients recurrence retroperitoneal sarcoma Sarcoma Surgery Survival |
| title | Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG |
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