Anti-inflammatory effects of androgens in the human vagina

Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and beneficial effects of androgens in the vagina have been described. We investigated the potential involvement of human vagina smooth muscle cells (hvSMCs) in the inflammatory response and the immunomodulatory effect...

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Veröffentlicht in:	Journal of molecular endocrinology 2020-10, Vol.65 (3), p.109-124
Hauptverfasser:	Maseroli, Elisa, Cellai, Ilaria, Filippi, Sandra, Comeglio, Paolo, Cipriani, Sarah, Rastrelli, Giulia, Rosi, Martina, Sorbi, Flavia, Fambrini, Massimiliano, Petraglia, Felice, Amoriello, Roberta, Ballerini, Clara, Lombardelli, Letizia, Piccinni, Marie-Pierre, Sarchielli, Erica, Guarnieri, Giulia, Morelli, Annamaria, Maggi, Mario, Vignozzi, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Androgens Androgens - pharmacology Animals Anti-Inflammatory Agents - pharmacology Cell culture Cell surface Cells, Cultured Cyclooxygenase-2 Dihydrotestosterone Dihydrotestosterone - pharmacology Female Flow cytometry Gene expression Gene Expression - drug effects Histocompatibility antigen HLA Humans Immunofluorescence Immunomodulation Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - prevention & control Inflammation Mediators - metabolism Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 15 Interleukin 2 Interleukin 5 Interleukin 6 Lipopolysaccharides Lipopolysaccharides - pharmacology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Polymerase chain reaction Primary Cell Culture Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Smooth muscle Toll-Like Receptors - genetics Toll-Like Receptors - metabolism Vagina Vagina - drug effects Vagina - metabolism Vagina - pathology Vascular endothelial growth factor γ-Interferon
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