Structure, energetics and thermodynamics of PLGA condensed phases from Molecular Dynamics

Poly-lactic-co-glycolic acid (PLGA) is a biodegradable co-polymer with common use in nanoparticle drug encapsulation. Although well studied experimentally, the mechanical behavior of PLGA is not well understood at the atomic level. Here, we develop atomic charges for the all-atom Generalized Amber F...

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Veröffentlicht in:	Polymer (Guilford) 2020-10, Vol.206, p.122903, Article 122903
Hauptverfasser:	Andrews, James, Handler, Robert A., Blaisten-Barojas, Estela
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradability Biodegradation Caloric curve Chain entanglement Copolymers Electrostatic properties Entanglement Glass transition Glass transition temperature Glycolic acid Mechanical properties Molecular dynamics Molecular weight Monomers Nanoparticles Poly(lactic-co-glycolic acid) (PLGA) Polylactide-co-glycolide Polymers Response thermodynamic properties Solid-state stability Transition temperatures
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