Alteration of methylation status in archival DNA samples: A qualitative assessment by methylation specific polymerase chain reaction

DNA methylation is an epigenetic mechanism that regulates gene expression, which also facilitates genomic imprinting. Genomic imprinting is responsible for differential expression of genes based on parent of origin. Altered methylation of parental alleles results in imprinting disorders diagnosed by...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2020-10, Vol.61 (8), p.837-842
Hauptverfasser:	Iyer, Gayatri Rangarajan, Hasan, Qurratulain
Format:	Artikel
Sprache:	eng
Schlagworte:	archival DNA Biological Specimen Banks Chromosome 15 Chromosomes Deoxyribonucleic acid diagnostic accuracy Disorders DNA DNA Methylation Epigenesis, Genetic Epigenetics Evaluation Gene expression Genes Genetic testing Genomic imprinting Heterogeneity Humans imprinting disorders MSPCR Polymerase chain reaction Polymerase Chain Reaction - methods Polymorphism snRNP Core Proteins - genetics Storage Storage conditions
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