Paper-Based Strip for Ultrasensitive Detection of OSCC-Associated Salivary MicroRNA via CRISPR/Cas12a Coupling with IS-Primer Amplification Reaction

As the most common malignancy in humans, oral squamous cell carcinoma (OSCC) not only harms the people’s health but also undermines their confidence after facial surgery. Early detection and treatment can effectively reduce these damages. The unique collateral trans-cleavage nuclease activity of clu...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-10, Vol.92 (19), p.13336-13342
Hauptverfasser:	Chen, Minghui, Luo, Ran, Li, Shenghui, Li, Hengxuan, Qin, Yi, Zhou, Dianming, Liu, Hao, Gong, Xiaoqun, Chang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Bacterial Proteins - genetics Biotin Chemistry Cleavage Coupling CRISPR CRISPR-Associated Proteins - genetics CRISPR-Cas Systems - genetics Digoxin Endodeoxyribonucleases - genetics Fluorescence Head and Neck Neoplasms - diagnosis Humans Malignancy MicroRNAs MicroRNAs - analysis MicroRNAs - genetics miRNA Nuclease Nucleic Acid Amplification Techniques Nucleic acids Oral squamous cell carcinoma Reagent Strips - chemistry Saliva - chemistry Single-stranded DNA Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - diagnosis Strip Surgery
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